A5038973806- Rheumatoid Arthritis Research and Therapies
- Work-Family Balance Challenges
- Gender, Labor, and Family Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Social Policy and Reform Studies
- Systemic Lupus Erythematosus Research
- Social Sciences and Policies
- Immunodeficiency and Autoimmune Disorders
- Spondyloarthritis Studies and Treatments
- Labor Law and Work Dynamics
- Cystic Fibrosis Research Advances
- Biosimilars and Bioanalytical Methods
- Gender Diversity and Inequality
- Immune cells in cancer
- Employment, Labor, and Gender Studies
- Family Dynamics and Relationships
- Respiratory Support and Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Inflammation biomarkers and pathways
- Intergenerational Family Dynamics and Caregiving
- Housing, Finance, and Neoliberalism
- Retirement, Disability, and Employment
- Employment and Welfare Studies
National University of Distance Education
2016-2024
Hospital La Paz Institute for Health Research
2011-2021
Universidad Pablo de Olavide
2018-2021
Universidad Publica de Navarra
2021
Universidad a Distancia de Madrid
2021
Universitat Oberta de Catalunya
2021
Colciencias
2021
Hospital Universitario La Paz
2015-2020
Centro de Ciencias Humanas y Sociales
2018
Distance State University
2015
Monocyte exposure to LPS induces a transient state in which these cells are refractory further endotoxin stimulation. This phenomenon, termed tolerance (ET), is characterized by decreased production of cytokines response the proinflammatory stimulus. We have established robust model ET and determined time frame features unresponsiveness cultured human monocytes. A large number genes transcribed tolerant monocytes were classified as either "tolerizable" or "nontolerizable" depending on their...
The aim of this study was to determine whether antibodies infliximab (IFX) in Remicade-treated patients cross-react with the biosimilar CT-P13.250 consecutive rheumatic diseases under Remicade and 77 controls were retrospectively selected for study. Anti-IFX at drug through levels measured parallel three different bridging ELISA assays: Promonitor-ANTI-IFX kit, which uses detect antibodies, two more assays that use either Inflectra or Remsima same format. Correlation association between each...
La forma de conciliar empleo y vida familiar varía significativamente dentro del colectivo madres también su acceso a las políticas permisos. Este artículo analiza por primera vez trayectorias laborales-familiares pautas conciliación en España desde una perspectiva longitudinal e interseccional. Para ello, partir los datos retrospectivos la Encuesta Fecundidad 2018, se lleva cabo un análisis secuencias multicanal para 18 55 años, según nivel educación país nacimiento. Los resultados muestran...
Cystic Fibrosis (CF) is an inherited pleiotropic disease that results from abnormalities in the gene codes of a chloride channel. The lungs CF patients are chronically infected by several pathogens but bacteraemia have rarely been reported this pathology. Besides that, circulating monocytes exhibit patent Endotoxin Tolerance (ET) state since they show significant reduction inflammatory response to bacterial stimulus. Despite previous description phenomenon, direct cause ET remains unknown....
Objective. To compare clinical outcomes, incidence of flares, and administered drug reduction between patients with spondyloarthritis (SpA) under TNF inhibitor (TNFi) tapering strategy receiving a standard regimen. Methods. In this retrospective study, 74 SpA from Spain on (tapering group; TG) were compared 43 the Netherlands regimen (control CG). The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was measured at visit 0 (prior to starting TNFi), 1 in TG least 6 months BASDAI...
Esta investigación analiza los planes de cuidado del primer hijo en parejas, indagando cómo infl uyen ideales maternidad/ paternidad, las actitudes género y limitaciones institucionales el proyecto bebé. El estudio se basa una muestra 68 parejas doble ingreso que esperaban su año 2011. análisis revela gran parte aspira a ambos cónyuges continúen trabajando después parto. Sin embargo, caso prever difi cultades conciliación, siguen siendo mujeres quienes manifi estan mayor predisposición...
Abstract This article analyses the role of gender, parenthood, and work flexibility measures mediating stereotypes on likelihood achieving an internal promotion in Spain. We hypothesize that employers favour fathers over mothers disfavour flexible workers (flexibility stigma) because they are perceived, respectively, as less competent committed. also reflect their gender values selection process. These hypotheses tested using data from a survey experiment which 71 supervisors private...
ABSTRACT The MMPs constitute a family of endopeptidases that can cleavage extracellular proteins. They are involved in number events; some these include inflammatory processes. One its targets is the TREM-1, which has emerged as an important modulator innate immune responses mammals. This transmembrane glycoprotein possesses Ig-like ectodomain readily shed by to generate sTREM-1. Whereas membrane-anchored TREM-1 amplifies responses, sTREM-1 exhibits anti-inflammatory properties. Here we show...
This article analyzes changes in the division of routine domestic work after first parenthood. We wanted to know whether and how it was possible for couples resist trend toward traditionalization that has been shown literature. To do so, we analyze semistructured interviews with 27 Spanish who were expecting their child 2011 interviewed them again 2013. The selected from a bigger sample because nontraditional practices preparenthood. Our results show 17 able maintain work, whereas 10...
The Infliximab, has proven effective in treating rheumatoid arthritis (RA). A good clinical response is usually associated with high serum drug levels. Development of antibodies toward Infliximab (ATI) can increase clearance, leading to treatment failure.To analyze whether trough levels (ITL) at the induction phase are clearance and outcomes week(W) 54 investigate association immunogenicity development.Observational retrospective study which ITL from 66 RA patients were measured by capture...
Controversy exists on the role of IgE antidrug antibodies (IgE-ADA) in infusion reactions (IR) infliximab treatment, partly due to lack a positive control used for assay validation. We sought (1) develop robust measure IgE-ADA, including control, (2) determine association between IgE-ADA and IR (3) incidence treated patients.A recombinant human anti-infliximab monoclonal antibody was developed as standard control. With this antibody, we set up novel IgE-ADA. determined three retrospective...
Background Evidence supporting treatment intensification in rheumatoid arthritis is limited and controversial. We explored outcomes of infliximab dose increases accounted for pre-existing trough levels patients with active (RA). Methods This study was a retrospective 42 RA who received increased following an insufficient response (DAS28 > 3.2). Serum concentrations antibodies to (ATI) DAS28 EULAR clinical parameters were recorded one year. Analyses performed three patient groups that defined...
This article studies 28 dual-income Spanish childless couples who were undoing gender in routine domestic work. We understand 'undoing gender' as defined by Deutsch [(2007). Undoing gender. Gender & Society, 21, 106–127, p. 122]: 'social interactions that reduce difference'. The dual-earner came from different socio-economic backgrounds and interviewed four towns 2011. analysis shows resources a wide sense, time availability, external help, ideas about fairness, complex attitudes are key...
Abstract Increasingly, men are challenging the assumption that care is a feminine task and involving themselves in childcare of dependent adults. However, this does not necessarily have consequences for their work, as they very rarely make costly adaptations working lives. In study, we propose definition man (MIC) father who, order to meet needs, has adapted his life way potentially entails financial penalty. We analyze prevalence among living with children below age 15 across EU‐27 plus...
A partir de los resultados una encuesta realizada en 2016 a muestra 5.002 jóvenes españoles entre 15 y 29 años, que da continuidad serie informes cuatrienuales sobre la situación juventud, se intenta responder cuestión qué sabemos del modus vivendi juventud española sale crisis. En esta reflexión colectiva profundiza el impacto crisis las condiciones laborales proceso precarización rol educación situaciones excepcionales, activación política amplios sectores frente idea extendida apatía...