A5050612329- Estrogen and related hormone effects
- Pregnancy-related medical research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hormonal and reproductive studies
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Birth, Development, and Health
- Retinoids in leukemia and cellular processes
- Antimicrobial Peptides and Activities
- Medical Imaging and Pathology Studies
- Hormonal Regulation and Hypertension
- Endometrial and Cervical Cancer Treatments
- Fungal Infections and Studies
- Pregnancy and preeclampsia studies
- Inhalation and Respiratory Drug Delivery
- Reproductive Biology and Fertility
- Histone Deacetylase Inhibitors Research
Tohoku University Hospital
2019
Tohoku University
2011-2018
ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis in immunocompromised patients. Recently, we reported Toll-like receptor 9 (TLR9) involved host defense against C. : specifically, it detects the pathogen's DNA. In present study, aimed to elucidate mechanisms underlying TLR9-mediated activation of innate immune responses by using URA5 gene, which encodes a virulent component this pathogen. A PCR-amplified 345-bp gene fragment induced...
Relaxin is known to play an important role in animal pregnancies, including those of humans. It suggested that relaxin induces aggressive cell growth and invasiveness several types cancer, endometrial cancer. However, the mechanisms remain largely unclear. In this study, we examined effects 2 (RLN2), major circulating humans, on human carcinoma lines. RLN2 treatment induced invasion HEC-1B Ishikawa cells. RLN2-induced was significantly decreased by transfection receptor 1 (RXFP1) siRNAs. The...
Endometrial cancer is one of the most common female pelvic cancers and has been considered an androgen-related malignancy. Several studies have demonstrated anti-cell proliferative effect androgen on endometrial cells; however, mechanisms anti-cancer remain largely unclear. 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), which catalyzes conversion E2 to E1, known be upregulated by treatment in breast cells. In this study, we therefore focused role estrogen dependence cancer....
Objective Several studies have reported that retinoic acid (RA) might be used to treat malignancies. The effects of RA are mediated by the receptor (RAR), and RARα/RARβ especially acts as a tumor suppressor. However, little is known about its role in human endometrial cancer. Materials Methods In this study, we examined all-trans (ATRA) on progression cancer cell line, RL95-2 Hec1A. We then expression RARα RARβ 50 tissues using immunohistochemistry. Results found inhibitory ATRA...
We have developed an automated device for the measurement of oxygen consumption rate (OCR) called Chip-sensing Embryo Respiratory Measurement system (CERMs). To verify safety and significance OCR by CERMs, we conducted comprehensive tests using a mouse model prior to clinical trials in human vitro fertilization (IVF) program. transfer revealed that measured CERMs did not compromise full-term development mice or their future fertility, was positively correlated with adenosine triphosphate...
The androgen receptor (AR) is known to play critical roles in the malignancy of prostate cancer as well management male reproductive organs. Endometrial carcinoma, one major female cancers, considered an androgen-related cancer. However, importance signaling through its endometrial carcinomas has not yet been clarified. We recently demonstrated significance and intracrine dihydrotestosterone (DHT) follows: 1) A positive status was significantly associated with high rates progression-free...