A5101774546- Antibiotic Resistance in Bacteria
- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Catalytic C–H Functionalization Methods
- Digital Imaging for Blood Diseases
- Catalytic Cross-Coupling Reactions
- Retinal Imaging and Analysis
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cardiac Arrhythmias and Treatments
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- Vibrio bacteria research studies
- Synthesis and Biological Activity
- Phosphodiesterase function and regulation
- Chemical Reactions and Isotopes
- Aortic aneurysm repair treatments
- Signaling Pathways in Disease
- Clostridium difficile and Clostridium perfringens research
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- RNA regulation and disease
Zhuhai People's Hospital
2021-2024
Jinan University
2021-2024
Seventh People's Hospital of Shanghai
2014
Sichuan University
2008-2013
Jinshan Hospital of Fudan University
2010
West China Hospital of Sichuan University
2010
Capital Medical University
2000
Abstract Exosomes are nanosized bilayer membrane vesicles that may mediate intercellular communication by transporting bioactive molecules, including noncoding RNAs, mRNAs, and proteins. Research has shown exosomes play an important role in acute myocardial infarction (AMI), but the function regulation of exosomal long RNAs (lncRNAs) AMI unclear. Thus, RNA sequencing (RNA-Seq) was conducted to investigate lncRNA transcriptome from MI patients identified 65 differentially expressed lncRNAs...
Abdominal aortic aneurysm (AAA) is a complex vascular disorder characterized by the progressive dilation of abdominal aorta, with high risk rupture and mortality. Understanding cellular interactions molecular mechanisms underlying AAA development critical for identifying potential therapeutic targets.
Acute coronary syndrome (ACS) is a predominant cause of mortality, and the prompt precise identification this condition crucial to minimize its impact. Recent research indicates that gut microbiota associated with onset, progression, treatment ACS. To investigate role, we sequenced 38 ACS patients before after percutaneous intervention statin therapy at three time points, examining differential species metabolic pathways. We observed decrease in abundance Parabacteroides , Escherichia...
Abstract A mild and clean protocol for the alkynylation coupling of aryl iodides with terminal alkynes has been developed in yields up to 99 % presence sulfonato‐Cu II (salen) water. Domino synthesis 2‐arylindoles from 2‐iodoaniline acetylene was successfully carried out by this catalytic system, catalyst could be easily recovered reused.
Background Many fundus imaging modalities measure ocular changes. Automatic retinal vessel segmentation (RVS) is a significant image-based method for the diagnosis of ophthalmologic diseases. However, precise challenging task when detecting micro-changes in images, e.g., tiny vessels, edges, lesions and optic disc edges. Methods In this paper, we will introduce novel double branch fusion U-Net model that allows one branches to be trained by weighting scheme emphasizes harder examples improve...
Enhanced cellular glucose uptake is a frequent characteristic of malignant cells. The Akt substrate 160 kDa (AS160) newly discovered for the protein kinase AKT, and phosphorylation AS160 (p-AS160) was recently recognized to play an important role in transport. However, studies on cancer do not yet exist. aim present study investigate p-AS160 level its correlation with clinicopathological parameters various biological markers breast cancer. Results showed that cancer, at key residue T642...
The target phosphodiesterase-4 (PDE-4) inhibitor H is a potential candidate for the treatment of chronic obstructive pulmonary disease and asthma. A six-step scalable synthesis (27% overall yield) features an efficient mild construction 1,7-naphthyridine ring system in E. fortuitous epimerization that generated D primarily as trans isomer (trans/cis = 95:5) was compromised subsequent conversion E into F 4:1).
The reason of high mortality acute myocardial infarction (AMI) was the lack exploring cellular and molecular mechanism AMI. Therefore, we explored crosstalk among cells, as well its potential mediating AMI.The gene expression profile peripheral blood, endothelial, platelets mononuclear cells were applied to differentially expressed genes (DEGs) analysis. ClusterProfiler package set enrichment analysis (GSEA) explore functional pathways DEGs in 3 types intravascular (endothelial, cells)...
Aims: To explore the feasibility, safety, and efficacy of 1-stop treatment percutaneous left atrial appendage occlusion (LAAO) combined with coronary intervention for patients nonvalvular fibrillation (AF) complicated heart disease (CHD). Methods Results: We retrospectively analyzed clinical data 6 AF CHD admitted from Zhuhai People’s Hospital April 2017 to June 2018. After operation, all were treated aspirin (100 mg qd) clopidogrel (75 1 year, which is considered long-term use...
Abstract An efficient catalytic system for the alkynylation of aryl iodides is presented, involving a water‐soluble Cu—sulfonatosalen complex.
Objective To establish a new method, applying high resolution melt, to discriminate the VEB-3 hypotype from clinical gram negative isolates. Methods From January December 2003,292 consecutive and non-repetitive gram-negative bacteria producing VEB extended spectrum β-lactamase (ESBL) were collected. Extract DNA of isolates with phenol-chloroform. PCR was performed amplify gene being template. After that, we fragment containing position 168. Then detect melt curve analyze them. At last,...
Objective To prepare antiserum specific to aminoacyl-3′′-adenylyltransferase ［AAD(3′′)］, and explore the application value of prepared in detecting expression levels aadA2 gene that downstream 8 different promoters (PcS, PcH2, PcH1, PcW, PcS-P2, PcH2-P2, PcH1-P2 PcW-P2) variable regions class 1 integron. Methods aadA2 was amplified by polymerase chain reaction（PCR） cloned into plasmid pET19b.After inducing, recombined aminoacyl-3′′-adenylyltransferase［AAD(3′′)］ with His-tag expressed,...
Objective To develop a simple high-resolution melting (HRM) analysis method for differentiation of Pc and P2 variants in class 1 integron. Methods DNA fragments containing were amplified from plasmids pACW (PcW) pACWP2 (PcW-P2) respectively, then these purified PCR products promoters analyed full-length amplicon by HRM. Eight DNA different site-specific mutated pACS (PcS), pACH2 (PcH2), pACH1 (PcH1), (PcW), genomic Klebsiellar pneumonia HS07-68(PcWTGN-10)and...
Objective To explore the clinical characteristics, drug resistance and prognosis of Klebsiella pneumoniae bloodstream infection (KP-BSI), to analyze risk factors death resistance. Methods The data hospitalized patients with KP-BSI from April 2015 2017 in Huashan Hospital were retrospectively analyzed. Continuous variables compared using t test. Categorical χ2 test or Fisher exact The independent for determined by logistic regression model. Results The majority 74 male (67.6%)...