L Zhang

ORCID: 0000-0002-8403-0228
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Research Areas
  • Hematopoietic Stem Cell Transplantation
  • Blood groups and transfusion
  • Acute Myeloid Leukemia Research
  • Lymphoma Diagnosis and Treatment
  • Hematological disorders and diagnostics
  • Acute Lymphoblastic Leukemia research
  • Chronic Myeloid Leukemia Treatments
  • Platelet Disorders and Treatments
  • Lung Cancer Treatments and Mutations
  • Hemophilia Treatment and Research
  • Blood disorders and treatments
  • MicroRNA in disease regulation
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Blood Coagulation and Thrombosis Mechanisms
  • Erythrocyte Function and Pathophysiology
  • Immunodeficiency and Autoimmune Disorders
  • Kruppel-like factors research
  • Chronic Lymphocytic Leukemia Research
  • Food Waste Reduction and Sustainability
  • Animal Genetics and Reproduction
  • Cancer-related gene regulation
  • Circular RNAs in diseases
  • Mesenchymal stem cell research
  • Neurological and metabolic disorders
  • Autophagy in Disease and Therapy

Guangdong Academy of Medical Sciences
2025

Southern Medical University
2025

Guangdong Provincial People's Hospital
2025

Jiangxi Academy of Agricultural Sciences
2025

Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024

Institute of Hematology & Blood Diseases Hospital
2010-2024

Nanjing University of Finance and Economics
2024

Chinese PLA General Hospital
2024

Chinese People's Liberation Army
2024

State Key Laboratory of Kidney Diseases
2024

Abstract Objective: To investigate the characteristics of laryngeal mucosal microvascular network in suspected cancer patients, using narrow band imaging, and to evaluate value imaging endoscopy early diagnosis precancerous cancerous lesions. Patients methods: Eighty-five consecutive patients with or lesions were enrolled study. Endoscopic findings classified into five types (I V) according features intraepithelial papillary capillary loops assessed. Results: A total 104 (45 malignancies 59...

10.1017/s0022215110002033 article EN The Journal of Laryngology & Otology 2010-11-08

Leaf functional traits (LFTs) are highly plastic and essential to plant resource acquisition utilization. However, the collinearity of environmental factors differences in response distinct types generate challenges clarifying contributions environment variables LFTs. This study selected 28 species from four forests northern China with similar mean annual precipitation (MAP) explore how other dissimilar influence LFTs after controlling for most influential factor. Specifically, we examined...

10.1016/j.ecolind.2024.112199 article EN cc-by Ecological Indicators 2024-06-12

Abstract Aim The purpose of this study was to investigate the diagnostic and prognostic value miR-320a-3p in chronic heart failure (CHF). Methods A total 103 patients with CHF 95 healthy controls were included population. expression level serum detected by qRT-PCR. effect on evaluated receiver operating characteristic curve. Kaplan-Meier curve Cox regression used analyze risk factors for 4-year prognosis patients. Bioinformatics analysis possible target genes related signaling pathways....

10.1186/s12872-024-03966-0 article EN cc-by BMC Cardiovascular Disorders 2024-06-17

Introduction Cardioplegia during cardiopulmonary bypass is essential for ensuring a surgical field free of blood and cardiac movement. Numerous cardioplegia solutions are available, but consensus guidelines about the safest or most effective do not exist. The present trial will compare Huaxi-1 solution, which has been used since 2006 with good results at major Chinese centre involved in this trial, widely Custodiol histidine-tryptophan-ketoglutarate (HTK) solution terms safety efficacy...

10.1136/bmjopen-2024-095660 article EN cc-by-nc-nd BMJ Open 2025-02-01

Food waste in household settings contributes 66% of the global carbon footprint food waste. Reducing at level is essential for environmental sustainability. Based on China Health and Nutrition Survey (CHNS) Life Cycle Assessment Database (CFLCAD), this paper explores resource impacts from perspective use refrigeration equipment as a refrigerator Chinese households, based life cycle theory. The primary findings are that (1) Refrigerator significantly reduces (2) Dietary knowledge plays...

10.3389/fsufs.2025.1502264 article EN cc-by Frontiers in Sustainable Food Systems 2025-02-28

Taihe Black-Boned Silky Fowl (TBSF) is a unique breed in China, characterized by high concentration of melanin deposited throughout its body. Compared to broiler chickens, many antibiotics exhibit significantly longer withdrawal periods TBSF. Given that antibiotic exposure widely recognized as the primary selective pressure driving persistence and dissemination resistance genes (ARGs) across diverse environments, it crucial investigate occurrence prevalence ARGs within TBSF farming systems....

10.1016/j.psj.2025.105082 article EN cc-by-nc-nd Poultry Science 2025-03-23

AimsThis study explored the molecular and biologic mechanisms underlying association between circadian rhythm disorders (CRD) increased risk for hepatocellular carcinoma (HCC).BackgroundCRD are linked to HCC, but this limited.ObjectiveThe constructed validated a CRD related gene model as an independent prognostic factor providing insight into linking HCC identifying potential indicators efficacy of immunotherapy anticancer drugs. This helps provide important clues personalized treatment...

10.1016/j.heliyon.2024.e33682 article EN cc-by-nc-nd Heliyon 2024-06-26

Food waste jeopardizes food security and causes economic resource losses. Household is the most significant source of global urgently needs to be reduced. Based on China Health Nutrition Survey (CHNS), our study estimates daily data 6,418 sample observations across dietary preference scores their household heads. Using a count regression model, explores relationship between in Chinese households, further moderating function refrigerator use. The has found that: (1) improving score can...

10.3389/fnut.2024.1415734 article EN cc-by Frontiers in Nutrition 2024-07-09

In order to achieve simply manufacturing process and higher volumetric power density, many planar SOFC stacks were designed place fuel air manifolds within the cell unit area penetrated it.The flow distribution qualities these type was analyzed by 3D calculating fluid dynamics (CFD) simulating, following results could be concluded: i) while placed through it, over 31% would pass semicircle zones of manifold zones; iii) 14% zone zone; iv) plane, both each not greatly improved adding...

10.20964/2017.01.13 article EN cc-by-nc-nd International Journal of Electrochemical Science 2016-12-14

To evaluate the impact of recombinant human thrombopoietin (rhTPO) on short-term response immunosuppressive therapy (IST) in patients with newly diagnosed acquired severe aplastic anemia (SAA).The clinical data forty adult SAA patients, who treated IST combined rhTPO, were retrospective analyzed and hematologic recovery compared by alone during same period. The factors affecting also analyzed.At 3 months after IST, both total rate CR+GPR rhTPO group much higher than those control (75.0% vs...

10.3760/cma.j.issn.0253-2727.2015.03.002 article EN PubMed 2015-03-01

8015 Background: Docetaxel (75 mg/m 2 ) has been reported as first-line and maintenance treatment for Western population with advanced NSCLC. Different doses of docetaxel (60 are currently delivered in Asian population. Pharmacogenomics alterations taxanes disposition different ethnic groups may explain this difference. TFINE study was to evaluate the efficacy, safety, tolerability setting, identify preferable dose Methods: Previously untreated patients, aged between 18 75 years,...

10.1200/jco.2013.31.15_suppl.8015 article EN Journal of Clinical Oncology 2013-05-20

Objective: To analyze the clinical manifestations and molecular pathogenesis of 18 patients with inherited protein S (PS) deficiency. Methods: Eighteen PS deficiency who were admitted to Institute Hematology & Blood Diseases Hospital from June 2016 February 2019 analyzed: activity C (PC) antithrombin (AT) , measured for phenotype diagnosis; high throughput sequencing (HTS) was used screening coagulation disease-related genes; Sanger confirm candidate variants; Swiss-model three-dimensional...

10.3760/cma.j.issn.0253-2727.2022.01.010 article EN PubMed 2022-01-14

Objective: To study the metabolic characteristics of anti-human T-cell porcine immunoglobulin (p-ATG) in patients with severe aplastic anemia (SAA) . Methods: For SAA treated p-ATG combined cyclosporine A (CsA) immunosuppressants between February 2017 and December 2017, dose was 20 mg·kg(-1)·d(-1) over 12 h intravenous administration for 5 consecutive days. The blood concentration detected by three-antibody sandwich ELISA method, pharmacokinetic analysis software fitted, second-chamber model...

10.3760/cma.j.issn.0253-2727.2022.04.006 article EN PubMed 2022-04-14

BackgroundICIs has improved the prognosis of NSCLC patients. but 20% patients experience life-threatening toxicity. Our goal is to develop a web-based calculator predict possibility severe toxicity in receiving immunotherapy for NSCLC.MethodProspective analysis with stage IIIC-IV treated PD-1 inhibitors between August 2019 and 2021, follow-up until 1, 2022. The primary endpoint study was grade determined according ASCO/NCCN guidelines. Patients sufficient pathological tissue detect tumor...

10.2139/ssrn.4725490 preprint EN 2024-01-01

To evaluate the clinical and prognostic differences in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) children under different diagnostic criteria (World Health Organization (WHO) 2016 WHO 2022 criteria).

10.3760/cma.j.cn112140-20230724-00029 article EN PubMed 2024-03-02
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