A5049035981- Prostate Cancer Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Bladder and Urothelial Cancer Treatments
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Pelvic floor disorders treatments
- MicroRNA in disease regulation
- Urinary and Genital Oncology Studies
- Urinary Tract Infections Management
- Epigenetics and DNA Methylation
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- 3D Printing in Biomedical Research
- Prostate Cancer Treatment and Research
- Cardiac Ischemia and Reperfusion
- Cancer, Lipids, and Metabolism
- Facial Rejuvenation and Surgery Techniques
- Additive Manufacturing and 3D Printing Technologies
- Antimicrobial Peptides and Activities
- Electrospun Nanofibers in Biomedical Applications
- Advanced X-ray and CT Imaging
- Cancer-related gene regulation
- Crystallography and molecular interactions
Gyeongsang National University
2022-2024
Gyeongsang National University Hospital
2018-2024
Korea University
2018-2023
Dr Youth Clinic
2015-2021
Sookmyung Women's University
2021
Hanil General Hospital
2006-2020
Korea Electric Power Corporation (South Korea)
2008-2020
Sungkyunkwan University
2015-2016
Bioengineering Center
2016
Suwon Research Institute
2016
Cell‐printing methods have been used widely in tissue regeneration because they enable fabricating biomimetic 3D structures laden with various cells. To achieve a cell‐matrix block, natural hydrogels that are nontoxic, biocompatible, and printable combined to obtain “bioinks.” Unfortunately, most bioinks, including those alginates, show low cell‐activating properties. Here, strategy for obtaining highly bioactive ink, which consisted of collagen/extracellular matrix (ECM) alginate, printing...
Electrohydrodynamic (EHD) direct writing has been used in diverse microelectromechanical systems and various supplemental methods for biotechnology electronics. In this work, we expanded the use of EHD-induced to fabricate 3D biomedical scaffolds designed as porous structures bone tissue engineering. To prepare scaffolds, modified a grounded target conventional EHD printing using poly(ethylene oxide) solution bath, elastically cushioning plotted struts prevent crumbling. The fabricated were...
Abstract We report a cell-dispensing technique, using core–shell nozzle and an absorbent dispensing stage to form cell-embedded struts. In the shell of nozzle, cross-linking agent flowed continuously onto surface dispensed bioink in core so that struts were rapidly gelled any remnant solution during process was absorbed into working stage, resulting high cell-viability strut stable formation three-dimensional mesh structure. The cell-printing conditions optimized by manipulating obtain...
Significance This work presents a concept for promoting the neuronal regenerative potential by engineering expression of stem cell marker, Prom1 . We identify as developmentally down-regulated intrinsic factor axon regeneration. Replenishing amplifies axonal transcriptionally inhibiting cholesterol metabolism via Smad-dependent signaling. provide evidence that reduction in synthesis empowers regrowth capacity. suggests Food and Drug Administration-approved cholesterol-lowering drugs are...
<b><i>Introduction:</i></b> In Korea, increasing attention has recently been given to the use of phytotherapeutic agents alleviate symptoms BPH. Serenoa repens shown have an equivalent efficacy Finasteride or Tamsulosin in treatment BPH previous studies. The present study was designed compare and safety plus tamsulosin with only over 12 months men LUTS secondary <b><i>Materials Methods:</i></b> One hundred forty symptomatic (IPSS ≥10) were...
No AccessJournal of UrologyAdult Urology1 Feb 2009The Clinical Significance in Healthy Men the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration In Ho Chang, Seung Hyun Ahn, June Han, Tae-Hyoung Kim, Young Sun Soon Chul Myung ChangIn Chang Department Urology, Chung-Ang University College Medicine, Seoul, Korea , AhnSeung Ahn KEPCO Medical Foundation, Hanil General Hospital, HanJune Han KimTae-Hyoung Kim KimYoung MyungSoon View All Author...
Biomedical scaffolds have been widely used to regenerate various tissues and organs. One technology for scaffold fabrication is rapid prototyping (RP), which has the advantage of easy control internal microstructure scaffolds. However, fabricated using RP show low resolution struts too smooth struts, can deteriorate initial cell attachment proliferation. To overcome this problem, we propose a hybrid combining system electrohydrodynamic (EHD) direct writing, generate highly roughened...
Velocardiofacial syndrome (VCFS) is associated with velopharyngeal insufficiency, which occurs in approximately 75% of VCFS patients. Surgical management insufficiency patients difficult a high revision rate due to the anatomic and physiological abnormalities velopharynx. The aims this study were evaluate thickness symmetry levator veli palatini (LVP) muscle using magnetic resonance imaging (MRI), compare findings those nonsyndromic submucous cleft palate. We conducted prospective analysis...
A mesenchymal stem cell (MSC)-laden scaffold was designed for use in mastoid obliteration.
We performed a retrospective study to examine the association between metabolic syndrome (MS)and risk for development of chronic kidney disease (CKD).This cohort included 60 921 healthy adults recruited from two health promotion centres.Anthropometric measures, blood pressure, fasting glucose, lipid profile and serum creatinine were evaluated. The glomerular filtration rate was estimated (eGFR) using abbreviated equation developed by Modification Diet in Renal Disease (MDRD) formula. CKD...
This study aimed to examine the endothelial dependence of vasodilation induced by phosphodiesterase inhibitor theophylline in isolated rat thoracic aortas and elucidate underlying mechanism, with emphasis on nitric oxide (NO). The effects various inhibitors denudation theophylline-induced vasodilation, effect NO donor sodium nitroprusside, cyclic guanosine monophosphate (cGMP) analog bromo-cGMP, β-agonist isoproterenol endothelium-denuded aorta were examined. nitroprusside cGMP formation...
To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-density lipoprotein, HDL) fasting blood sugar (FBS), to determine significant factors for predicting PSA in men with a low risk of having prostate cancer.In all, 38 157 healthy male employees Korea Electric Power Corporation (KEPCO) who were aged <60 years...
Background: Angloplasty is the most common procedure in facial contouring surgery among Asians. However, to achieve satisfactory results during procedures aimed at altering lower contour, shape of mandible and chin area particular an important consideration. In cases reoperation for further improvement after angloplasty, surgeons should consider performing a genioplasty improve chin. Methods: From March 2010 August 2012, 52 women who were dissatisfied with angloplasty wanted slimmer face...
Protein arginine methyltransferase (PRMT) 1 is involved in the regulation of various metabolic pathways such as glucose metabolism liver and atrophy skeletal muscle. However, role PRMT1 fat tissues under disease state has not been elucidated to date. In this study, we delineate function protein adipocytes vivo. expression was abundant white adipose (WAT), which induced upon a high-fat diet mice by obesity humans. We found that adipocyte-specific depletion Prmt1 resulted decreased mass...
The aim of this study was to examine the effects lipid emulsions on carnitine palmitoyltransferase I (CPT-I), acylcarnitine translocase (CACT), II (CPT-II), and mitochondrial dysfunctions induced by toxic doses local anesthetics in H9c2 rat cardiomyoblasts. activities CPT-I, CACT, CPT-II, concentrations were examined. emulsions, N-acetyl-L-cysteine (NAC), mitotempo bupivacaine-induced changes cell viability, reactive oxygen species (ROS) levels, membrane potential (MMP), intracellular...
Small interfering RNAs (siRNAs) therapeutically induce RNA interference (RNAi) of disease-causing genes, but they also silence hundreds seed-matched off-targets as behaving similar to microRNAs (miRNAs). miRNAs control the pathophysiology tumors, wherein their accessible binding sites can be sequenced by Argonaute crosslinking immunoprecipitation (AGO CLIP). Herein, based on AGO CLIP, we develop potent anticancer siRNAs utilizing miRNA-like activity (mi/siRNAs). The mi/siRNAs contain seed...
This study aimed to examine the effect of lipid emulsion on vasodilation induced by a toxic dose amlodipine in isolated rat aorta and elucidate its mechanism, with particular focus nitric oxide. The effects endothelial denudation, NW-nitro-L-arginvine methyl ester (L-NAME), methylene blue, emulsion, linolenic acid amlodipine-induced cyclic guanosine monophosphate (cGMP) production were examined. Furthermore, amlodipine, PP2, either alone or combined, oxide synthase (eNOS), caveolin-1,...
We examined whether the body mass index and change of weight are associated with prostate specific antigen level as well rate velocity in healthy young Korean men.We enrolled this study 8,176 men who were younger than 51 years whom was evaluated at least 3 times. Bivariate multivariate general linear models used to assess independent contributions age, antigen. Mean compared for different ranges, ages, indexes changes using ANOVA tests. Linear logistic regression analysis determine variables...
<b><i>Introduction:</i></b> We investigated the value of transitional zone index (TZI) for predicting treatment response to combination therapy involving α-blockers and 5α-reductase inhibitors benign prostatic hyperplasia (BPH). <b><i>Materials Methods:</i></b> Symptomatic BPH patients (n = 118) were randomized receive 0.2 mg tamsulosin alone or with 0.5 dutasteride daily 12 months. The TZI, International Prostate Symptom Scores, maximum...
Background: Percutaneous aspiration with sclerotherapy (PAS) and laparoscopic marsupialization (LM) are minimally invasive treatment modalities for renal cysts. We aimed to compare the efficacy cost/effectiveness of LM PAS simple symptomatic Methods: Data were prospectively collected from three health care institutions in which 80 patients cysts underwent a single session 95% ethanol (PAS group, n = 40) or under general anesthesia (LM between March 2012 May 2016. compared patient profile,...