A5048746698- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational and environmental lung diseases
- Connective tissue disorders research
- Pleural and Pulmonary Diseases
- Pulmonary Hypertension Research and Treatments
- Microbial metabolism and enzyme function
- Williams Syndrome Research
- Liver physiology and pathology
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Cerebrovascular and genetic disorders
- Fibroblast Growth Factor Research
- Occupational exposure and asthma
- Wnt/β-catenin signaling in development and cancer
- Inhalation and Respiratory Drug Delivery
- Cardiomyopathy and Myosin Studies
- Neonatal Respiratory Health Research
- Protease and Inhibitor Mechanisms
- Systemic Sclerosis and Related Diseases
- Delphi Technique in Research
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
Nordic Bioscience (Denmark)
2013-2024
Technical University of Denmark
2015-2016
Exacerbations of chronic obstructive pulmonary disease (COPD) contribute significantly to progression. However, the effect on tissue structure and turnover is not well described. There an urgent clinical need for biomarkers activity associated with Extracellular matrix (ECM) reflects in tissues consequently assessment ECM may serve as activity. We hypothesized that lung proteins were altered during exacerbations COPD.69 patients COPD hospitalised exacerbation recruited at admission returned...
During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one major constituents parenchyma. However there are no non-invasive methods to quantify NE degradation elastin. We selected specific elastin fragments generated by for antibody generation and developed an ELISA assay (EL-NE) quantification NE-degraded Monoclonal antibodies were against 10 NE-specific cleavage sites on One EL-NE was tested analyte stability, linearity intra- inter-assay variation....
<b>Background:</b> ECM remodeling of the lung tissue releases protein fragments into blood, where they may potentially be detected as serological surrogate markers disease activity in COPD. No biomarkers have yet been associated with progression, mortality or AECOPD. <b>Methods:</b> We prospectively evaluated 638 patients stable COPD, GOLD II-IV, >10 PY from 8 European countries. The primary outcome study was exacerbation and death. Median observation time 24 months. Serum levels...
e22225 Background: The extracellular matrix (ECM) is an important part of malignant tumors the lung. lung ECM consists several proteins, where structural proteins are type I collagen and elastin as well intermediate filament (IMF) such vimentin, that play tissue quality function. turnover (formation degradation) these dysregulated changes. We investigated whether serum biomarkers reflecting IMF could be used to differentiate cancer patients other pathologies from healthy controls. Methods:...