A5035796788- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Acne and Rosacea Treatments and Effects
- Leprosy Research and Treatment
- Transgenic Plants and Applications
- Ocular Surface and Contact Lens
- Antimicrobial Peptides and Activities
- Toxin Mechanisms and Immunotoxins
- Drug-Induced Ocular Toxicity
- Pharmacological Effects of Natural Compounds
- Antimicrobial Resistance in Staphylococcus
- Biochemical and Structural Characterization
Trinity College Dublin
2017-2022
ABSTRACT Staphylococcus aureus skin infection is a frequent and recurrent problem in children with the common inflammatory disease atopic dermatitis (AD). S. colonizes of majority AD exacerbates disease. The first step during colonization bacterial adhesion to cornified envelope corneocytes outer layer, stratum corneum. Corneocytes from are structurally different normal healthy skin. objective this study was identify proteins that promote adherence corneocytes. strains clonal complexes 1 8...
Carriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during flares and overall correlate with increased burden S. aureus. Treatment AD therefore often targets topical systemic antimicrobials. To determine whether antimicrobial sensitivities genetic determinants resistance differed isolates from the children healthy child nasal carriers. In this case–control study, we compared (n = 50) attending a hospital...
colonizes the skin of majority patients with atopic dermatitis (AD), and its presence increases disease severity. Adhesion
Staphylococcus aureus infections have become a major challenge in health care due to increasing antibiotic resistance. We aimed design small molecule inhibitors of S. surface proteins be developed as colonization inhibitors. identified allantodapsone an initial screen searching for clumping factors A and B (ClfA ClfB). used microbial adhesion assays investigate the effect on extracellular matrix protein interactions. Allantodapsone inhibited Newman fibrinogen with IC50 21.3 μM (95% CI...
异位性皮炎(AD, 通常也称为湿疹)是儿童时期最常见的皮肤病之一, 英国和爱尔兰多达 1/4 的儿童受其影响。AD 患者经常在其皮肤上携带金黄色葡萄球菌。当患有 AD 的个体出现爆发时,即皮肤发红和瘙痒增加,皮肤上通常会有更多的金黄色葡萄球菌。因此通常用抗生素治疗 AD。这项研究在爱尔兰都柏林和英国圣安德鲁斯进行,旨在了解与未患 的儿童相比, 患儿的金黄色葡萄球菌的抗生素耐药性(意味着细菌能够抵抗杀死它们的抗生素)的差异。从 50 名在皮肤病诊所就诊的患有 的儿童中收集皮肤拭子,并在急诊科就诊的 49 名儿童中收集拭子,这些儿童在其鼻腔中无害地携带细菌。检查来自两组儿童的金黄色葡萄球菌的DNA(遗传密码),并用常用抗生素测试样品以鉴定哪些抗生素成功地杀死细菌。来自 儿童的总体样本对抗生素夫西地酸 (FA) 的耐药性是未患 儿童的两倍多,该药物通常以乳膏形式治疗皮肤感染。遗传密码显示,与未患 的儿童相比,AD 患儿的样本中通过不同机制发生了对 FA 的耐药性。最后,可能允许细菌在抗菌皂中存活的基因在 样本中比在非 样本中常见八倍。这表明用于 的治疗可以影响来自...