A5049042478- Cardiovascular and exercise physiology
- Sodium Intake and Health
- Nutritional Studies and Diet
- Electrolyte and hormonal disorders
- Heart Rate Variability and Autonomic Control
- Neonatal and fetal brain pathology
- Muscle metabolism and nutrition
- Renal function and acid-base balance
- Diet, Metabolism, and Disease
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Thermoregulation and physiological responses
- Hormonal Regulation and Hypertension
- Sports Performance and Training
- Human Health and Disease
- Motivation and Self-Concept in Sports
- Blood Pressure and Hypertension Studies
- Cardiovascular Effects of Exercise
University of Delaware
2021-2025
Increased dietary sodium is linked to hypertension, but most young adults display "sodium-resistant" blood pressure (BP), meaning BP not elevated with loading. In sodium-resistant rodents, fructose induces salt-sensitive via increased renal reabsorption. Therefore, we tested the impact of and on handling in healthy adults, hypothesizing that their combination would impair excretion increase BP. Thirty-six participants enrolled a randomized, double-blind, crossover trial involving three diets...
Endurance performance declines with advancing age. Of the three main physiological factors that determine endurance running [maximal oxygen consumption (V̇o
Background: Salt sensitivity and inverse salt [ISS; a reduction in blood pressure (BP) on high sodium diet] are each associated with increased incidence of hypertension. The purpose this analysis was to determine the prevalence ISS normotensive adults whether is any demographic characteristic(s). Method: Healthy normotensive, nonobese [ n = 84; 43 women; age 37 ± 13 years; baseline mean arterial (MAP) 89 8 mmHg] participated controlled feeding study, consuming 7-day low-sodium (20 mmol...
Acute exercise increases serum brain-derived neurotrophic factor (BDNF). In addition, a few studies have identified an inverse relation between resting BDNF and cortisol (CORT). PURPOSE: To investigate the association changes in CORT following bout of moderate-intensity continuous (MICE) high-intensity interval (HIIE). METHODS: Ten healthy men (age = 20 + 1 yr, BMI 23.13 3.12 kg) participated study. Each subject performed VO2peak test to determine peak workload (Wpeak) followed by two time-...
Nocturnal blood pressure (BP) dipping is a reduction in BP from wake to sleep. Blunted nocturnal (i.e., less of during sleep) associated with higher cardiovascular mortality. Physical activity and exercise training are greater improved) adults hypertension other clinical conditions. However, there limited data examining habitual physical healthy young adults. PURPOSE: To test the hypothesis that positively METHODS: This retrospective analysis includes 32 (19 male/13 female, age = 24 ± 3 yr,...
Rodent studies have identified specialized sodium chloride (NaCl)-sensing neurons in the circumventricular organs (CVOs), which mediate NaCl-induced changes sympathetic nerve activity, arginine vasopressin (AVP), thirst, and blood pressure (BP). In humans, acute hypernatremia has been shown to increase AVP, thirst BP. However, few human investigated network of NaCl sensing regions brain using functional magnetic resonance imaging (fMRI).To determine how connectivity change during an...
Impaired vascular function likely contributes to the association between dietary sodium intake and development of cardiovascular disease. Using cutaneous microvasculature as a model, we have previously shown that high (HS) diet blunts local heating-induced vasodilation in normotensive individuals with salt resistant (SR) blood pressure (BP). However, effect HS on sensitive (SS) remains unclear. Therefore, tested hypothesis microvascular is reduced by greater degree SS compared SR...
Inverse salt sensitivity, a sodium induced reduction in blood pressure (BP), has recently been associated with increased incidence of hypertension. However, there is paucity data regarding the prevalence inverse sensitivity (ISS). Therefore, purpose this retrospective analysis was to determine ISS cohort normotensive adults (n=111; age=37±13yr) and if any demographic characteristic(s). Subjects included healthy, normotensive, non-obese who participated controlled feeding study, consuming...