A5071217621- Cardiovascular Health and Disease Prevention
- Photocathodes and Microchannel Plates
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Dialysis and Renal Disease Management
- Adaptive optics and wavefront sensing
- Calibration and Measurement Techniques
- Non-Invasive Vital Sign Monitoring
- Solar and Space Plasma Dynamics
- Sodium Intake and Health
- Dark Matter and Cosmic Phenomena
- Electron and X-Ray Spectroscopy Techniques
- Infrared Target Detection Methodologies
- Cerebrovascular and Carotid Artery Diseases
- Thermoregulation and physiological responses
- Cardiac Imaging and Diagnostics
- Radiation Detection and Scintillator Technologies
- CCD and CMOS Imaging Sensors
- Astronomy and Astrophysical Research
- Astronomical Observations and Instrumentation
- Hemodynamic Monitoring and Therapy
- Advanced optical system design
- Nitric Oxide and Endothelin Effects
- Ionosphere and magnetosphere dynamics
University of Delaware
2018-2025
East Carolina University
2025
Carl Zeiss (Germany)
2021
K Lab (United States)
2018
Stinger Ghaffarian Technologies (United States)
2008-2010
Ghent University
2010
University of California, Berkeley
1991-2003
Endothelial dysfunction and arterial stiffness are nontraditional risk factors of chronic kidney disease (CKD)-related cardiovascular (CVD) that could be targeted with exercise. This study investigated the effect moderate to vigorous aerobic exercise on vascular function in nondialysis CKD. In this randomized, controlled trial, 36 patients CKD (means ± SE, age: 58 2 yr, estimated glomerular filtration rate: 44 ml·min-1·1.73 m-2) were allocated an training (EXT) or control (CON) arm. The EXT...
Increased arterial wave reflections can increase left ventricular wasted pressure effort (WPE) and cardiovascular disease risk. Naturally menstruating women experience fluctuations in sex hormones with known cardioprotective effects. We sought to determine whether hormonal alter hemodynamics or reflections, thereby WPE, contribute differences. hypothesized that premenopausal would have favorable reflection changes reduced WPE during high- vs. low-hormone cycle phases compared men. tested 13...
Increased dietary sodium is linked to hypertension, but most young adults display "sodium-resistant" blood pressure (BP), meaning BP not elevated with loading. In sodium-resistant rodents, fructose induces salt-sensitive via increased renal reabsorption. Therefore, we tested the impact of and on handling in healthy adults, hypothesizing that their combination would impair excretion increase BP. Thirty-six participants enrolled a randomized, double-blind, crossover trial involving three diets...
Objective: Unimolecular triagonists drive substantial weight loss in patients with obesity (PwO) by engaging the glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) receptors to reduce food intake (FI) hepatic glucagon (Gcg) receptor enhance energy expenditure (EE). However, their development has been challenged deleterious cardiovascular (CV) effects including increased heart rate (HR), elongated QTc, arrhythmia mediated GcgR agonism. GLP-1R monoagonists...
Background Reductions in exercise capacity associated with intolerance augment cardiovascular disease risk and predict mortality chronic kidney disease. This study utilized cardiopulmonary testing to (a) investigate mechanisms of intolerance; (b) unmask subclinical abnormalities that may precede Design The design this was cross-sectional. Methods Cardiopulmonary carried out 31 Stage 3–4 patients (60 ± 11 years; estimated glomerular filtration rate 43 13 ml/min/1.73 m 2 ) 21 matched healthy...
Mitochondria-derived oxidative stress has been implicated in vascular and skeletal muscle abnormalities chronic kidney disease (CKD). The purpose of this study was to investigate the effects a mitochondria-targeted ubiquinol (MitoQ) on function exercise capacity CKD. In randomized controlled trial, 18 patients with CKD (means ± SE, age: 62 3 yr estimated glomerular filtration rate: 45 mL/min/1.73 m2) received 4 wk 20 mg/day MitoQ (MTQ group) or placebo (PLB). Outcomes assessed at baseline...
The Galaxy Evolution Explorer (GALEX), a NASA Small Mission planned for launch in Fall 2002, will perform the first Space Ultraviolet sky survey. Five imaging surveys each of two bands (1350-1750Å and 1750-2800Å) range from an all-sky survey (limit m<sub>AB</sub>~20-21) to ultra-deep 4 square degrees m<sub>AB</sub>~26). Three spectroscopic grism (R=100-300) be performed with various depths (m<sub>AB</sub>~20-25) coverage (100 2 degrees) over 1350-2800Å band. instrument...
We demonstrate that triangular flow waveforms overestimate wave reflection indices, particularly at higher central pulse pressures independent of age or carotid-femoral velocity. In contrast, personalized physiologic provide equivalent estimates as measured waveforms, thereby offering a more robust alternative to triangulation when aortic cannot be measured.
The GALEX instrument consists of a 50cm normal incidence mirror telescope in combination with grism, and dichroic beamsplitter system projecting images onto two detectors simultaneously. objective this is to provide sensitive high resolution imaging galaxies bandpasses, the option modest spectroscopy. We are currently developing microchannel plate, delay line, sealed tube for Galaxy Evolution Explorer mission be launched 2001.
Microchannel plate based detectors with cross delay line image readout have been rapidly implemented for the SUMER and UVCS instruments aboard Solar Orbiting Heliospheric Observatory (SOHO) mission to be launched in July 1995. In October 1993 a fast track program build characterize detector control electronics was initiated. We present system design SOHO programs, results from test program. Two deliverable built at this point, demonstration model UVCS, flight Ly (alpha) both of which are...
The microchannel plate, delay line, detectors developed for the far ultraviolet spectroscopic explorer mission to be launched in 1998 are described. two FUSE have a large format (approximately equals 184 mm by 10 split into 88.5 segments), with high spatial resolution (less than 20 micrometers 50 FWHM, greater 9000 200 elements) and good linearity (plus or minus 25 micrometers), image stability, counting rates excess of 4 10<SUP>4</SUP> events sec<SUP>-1</SUP>. KBr opaque photocathodes been...
Early return and increased magnitude of wave reflection augments pulsatile load, wastes left ventricular effort, is associated with cardiovascular events. Acute handgrip (HG) exercise increases surrogate measures such as augmentation index. However, index does not allow distinguishing between timing versus affected by factors other than per se. Wave separation analysis decomposes central pressure into relative contributions forward (Pf) backward (Pb) amplitudes to calculate (RM = Pb/Pf)...
The microchannel plates for the detectors in SUMER and UVCS instruments aboard Solar Orbiting Heliospheric Observatory (SOHO) mission to be launched late 1995 are described. A low resistance Z stack of (MCPs) is employed a detector format 27 mm multiplied by 10 using multilayer cross delay line anode (XDL) with 1024 360 digitized pixels. MCP stacks provide gains greater than 2 10<SUP>7</SUP> good pulse height distributions (as as 25% FWHM) under uniform flood illumination. Background rates...
The James Webb Space Telescope (JWST) is a general astrophysics mission which consists of 6.6m diameter, segmented, deployable telescope for cryogenic IR space astronomy (~35K). JWST Observatory architecture includes the Optical Element and Integrated Science Instrument Module (ISIM) element that contains four science instruments (SI) including Guider. alignment philosophy ISIM such changes in SI interfaces are captured error budget. SIs aligned to structure's coordinate system under...
Cardiovascular disease (CVD) is the leading cause of death in chronic kidney (CKD). Abnormal arterial hemodynamics contribute to CVD, a relationship that can be mediated by microvascular dysfunction. The purpose this study was investigate potential sex differences and dysfunction patients with stages 3 4 CKD. Vascular function assessed 22 male (mean ± SD; age, 56 13 yr) 10 female (age, 63 9 patients. Arterial were acquired combined tonometry oscillometry. Skin blood flow used as model...
Aging increases arterial stiffness and wave reflections that augment left ventricular wasted pressure effort (WPE). A single bout of exercise may be effective at acutely reducing WPE via reductions in reflections. In young adults (YA) acute aerobic decreases, whereas handgrip increases, Whether mitigates or exacerbates reflection healthy aging warrants further examination. The purpose this study was to determine if there are age-related differences during exercise. When compared with...
Developments in high resolution double delay line (DDL) and cross image readouts for applications UV soft X-ray imaging spectroscopy are described. Our current DDL's achieve approximately equals 15 micrometers X 25 FWHM over 65 mm (> 4000 500 elements) with counting rates of > 10<SUP>5</SUP> (10% dead time), good linearity (+/- 1 element) stability. We have also developed multilayer anodes external serpentine lines which currently give 20 both axes, (approximately 30 ) flat field...
We have developed compact microchannel plate detectors utilizing a cross delay line readout system for the IMAGE- FUV Spectrographic Imager. present description of detector head assembly and performance data typical both detectors. Both are nearly identical, only different being position input window on front cover. Each detector, optimized operation in far UV with KBr photocathode, provides high spatial resolution good linearity over 20 mm square format.
What is the central question of this study? There a paradoxical reduction in augmentation index during lower-body dynamic (LBD) exercise face an increase pressure. To determine causality, amplitudes forward and backward pressure waves were assessed separately using wave separation analysis. main finding its importance? Reflection magnitude decreased LBD healthy young adults was attributable to increased amplitude amplitude. This vasoactive response might limit adverse effects reflection...
The LOng-Range Reconnaissance Imager (LORRI) is a panchromatic imager for the New Horizons Pluto/Kuiper belt mission. being prepared launch in January 2006 as inaugural mission NASA's Frontiers program. This paper discusses calibration and characterization of LORRI. LORRI consists Ritchey-Chretien telescope CCD detector. It provides narrow field view (0.29°), high resolution (pixel FOV = 5 μrad) image at f/12.6 with 20.8~cm diameter primary mirror. acquired 1024 x pixel detector (model...
The alignment philosophy of the James Webb Space Telescope (JWST) Integrated Science Instrument Module (ISIM) is such that cryogenic changes in science instruments (SIs) and telescope-related interfaces are captured an error budget. SIs aligned to structure's coordinate system under ambient, clean room conditions using laser tracker theodolite metrology. ISIM structure thermally cycled temperature-induced mechanical structural concurrently measured ensure they within predicted boundaries. We...