A5026973810- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Species Distribution and Climate Change
- Renal cell carcinoma treatment
- SARS-CoV-2 and COVID-19 Research
- Marine animal studies overview
- Geometric and Algebraic Topology
- Long-Term Effects of COVID-19
- Diaspora, migration, transnational identity
- Water Quality Monitoring Technologies
- Smart Grid Energy Management
- Animal Behavior and Reproduction
- Botanical Research and Applications
- Clostridium difficile and Clostridium perfringens research
- Robotics and Sensor-Based Localization
- Intensive Care Unit Cognitive Disorders
- Urinary and Genital Oncology Studies
- Viral gastroenteritis research and epidemiology
- Historical and Archaeological Studies
- Botany, Ecology, and Taxonomy Studies
- Service-Learning and Community Engagement
- Underwater Vehicles and Communication Systems
Then Try This
2016-2023
James Cook University Hospital
2021-2022
University of Dundee
2021
National Health and Medical Research Council
2021
Intensive Care National Audit & Research Centre
2021
Medical Research Council
2021
University Hospital Southampton NHS Foundation Trust
2021
Public Health Scotland
2021
The University of Melbourne
2020
Austin Health
2020
The 2005 International Society of Urological Pathology (ISUP) modification Gleason grading recommended that the highest grade should always be included in score (GS) prostate biopsies. We analysed impact this recommendation on reporting GS 6 versus 7. Fifteen expert uropathologists reached two-thirds consensus 15 biopsies with 6-7 cancer. Eighty-five microphotographs were graded by 337 617 members European Network Uropathology (ENUP), representing 19 countries. There was agreement between...
The symptoms of Clostridium difficile infection are caused by toxins expressed from its 19 kb pathogenicity locus (PaLoc). Stable integration the PaLoc is suggested single chromosomal location and clade specificity different genetic variants. However, variably present, even among closely related strains, thus resembles a mobile element. Our aim was to explain these apparently conflicting observations reconstructing evolutionary history PaLoc. Phylogenetic analyses annotation regions spanning...
Increased gap junction expression in lamina propria myofibroblasts and urothelial cells may be involved detrusor overactivity, leading to incontinence. Immunohistochemistry was used compare connexin (Cx) 26, 43, 45 the bladders of neonatal, adult, spinal cord-transected rats, while optical imaging map spread spontaneous activity effects blockade. Female adult Sprague-Dawley rats were deeply anesthetized, a laminectomy performed, cord transected (T8/T9). After 14 days, their those age-matched...
This study examined the origin of spontaneous activity in neonatal and adult rat bladders effect stretch muscarinic agonists antagonists on activity. Rats were anesthetized their excised, cannulated, loaded with voltage- Ca(2+)-sensitive dyes. Intracellular Ca(2+) membrane potential transients mapped using photodiode arrays whole bladders, bladder sheets, or cross-section preparations at 37 degrees C. Intravesical pressure was recorded from bladders. In electrical signals arose a site near...
Carcinoid tumours of the appendix are generally thought to be derived from enterochromaffin cells; in-situ abnormalities these cells are, however, rarely observed in mucosal epithelium. One hundred appendices, removed consecutively at surgery, were stained with an alcian blue-PAS diastase-lead haematoxylin sequence and, 69, found lamina propria a cellular and architectural morphology identical those archetypal appendiceal carcinoid tumour. These appeared contain neurosecretory granules,...
The AKT/PI3K/mTOR pathway is frequently altered in a range of human tumours, including bladder cancer. Here we report the phenotype mice characterised by deletion two key players mTOR regulation, Pten and Lkb1, tissues mouse urothelium. Despite widespread recombination within epithelial tissues, primary observe rapid onset tumorigenesis, with median approximately 100 days. Single either or Lkb1 had no effect on cell proliferation tumour formation. However, simultaneous led to an upregulation...
The Gleason scoring system underwent revision at the International Society of Urological Pathology (ISUP) conference in 2005. It is not known how uropathologists have interpreted its recommendations.A web-based survey to European Network Uropathology members received replies from 266 pathologists 22 countries. Eighty-nine per cent claimed follow ISUP recommendations. Key areas disagreement included following. Smoothly rounded cribriform glands were assigned pattern (GP) 3 by 51% and GP 4...
No AccessJournal of UrologyClinical Urology: Original Article1 Feb 1997Tumors in Bladder Remnant After Augmentation Enterocystoplasty Julian W. Barrington, Simon Fulford, David Griffiths, and Timothy P. Stephenson BarringtonJulian Barrington , FulfordSimon Fulford GriffithsDavid Griffiths StephensonTimothy View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65181-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked...
The role of symptomatic patients who are toxigenic strain positive (TS+) but fecal toxin negative (FT–) in transmission Clostridium difficile is currently unknown. We investigated the contribution TS+/FT– and TS+/FT+ C. 2 UK regions. From 2-step testing, all glutamate dehydrogenase (GDH)–positive specimens, regardless result, from Oxford (April 2012 through April 2013) Leeds (July microbiology laboratories underwent culture whole-genome sequencing (WGS), using WGS to identify strains....
The Galaxy Evolution Explorer (GALEX), a NASA Small Mission planned for launch in Fall 2002, will perform the first Space Ultraviolet sky survey. Five imaging surveys each of two bands (1350-1750Å and 1750-2800Å) range from an all-sky survey (limit m<sub>AB</sub>~20-21) to ultra-deep 4 square degrees m<sub>AB</sub>~26). Three spectroscopic grism (R=100-300) be performed with various depths (m<sub>AB</sub>~20-25) coverage (100 2 degrees) over 1350-2800Å band. instrument...
To collect information on current practices of European pathologists for the handling and reporting nephrectomy specimens with renal tumours.A questionnaire was circulated to members Network Uropathology, which consists 343 in 15 countries. Replies were received from 48% members. These replies indicated that are most often formalin. Lymph nodes found less than 5% specimens. All respondents give an objective measure tumour size, commonly three diameters. The common method search capsule...
There is huge diversity in visual systems and color discrimination abilities, thought to stem from an animal's ecology life history. Many primate species maintain a polymorphism vision, whereby most individuals are dichromats but some females trichromats, implying that selection sometimes favors dichromatic vision. Detecting camouflaged prey be task where could have advantage. However, previous work either has not been able disentangle camouflage detection other ecological or social...
It is unclear whether the reported variation in diagnosis of intraductal carcinoma prostate (IDC-P) due to variable interpretation borderline morphology, use different diagnostic criteria or both.We sought determine degree and reporting rules for IDC-P biopsies employed by expert uropathologists.A questionnaire survey was circulated 23 uropathologists from 11 European countries.Criteria used included solid growth (100%), dense cribriform (96%), loose cribriform/micropapillary with nuclear...
Based upon fieldwork conducted amongst Somalis and Kurds in London, this paper examines the origin role of community associations both groups with a focus on differential capacity to utilize public space. The contrast between is initially drawn terms Kunz's typology refugee which emphasizes their relation political conflict country origin. In current research group-wide typological analysis has proven less viable than divisions within communities. While fragmentary forms organization...
No study has used whole-genome sequencing (WGS) to investigate risk factors for Clostridium difficile (CD) transmission between cases, or assessed the impact of recent acquisition on patient outcome. This 20 month retrospective cohort included consecutive cytotoxin-positive diarrheal samples, which underwent culture, ribotyping, and WGS (Illumina). Sequenced isolates were compared using single nucleotide variants (SNVs). Independent predictors from another case, onward transmission, 120-day...
The distribution of vegetation within urban zones is well understood to be important for delivery a range ecosystem services. While planners and human geographers are conversant with methodologies describing exploring the volumetric nature built spaces there less research that has developed imaginative ways visualising complex spatial structure from treetops ground. Using waveform LiDAR data measure three-dimensional greenspace, we explore different virtually, tangibly engaging models 3D...
Abstract BACKGROUND: Extracellular signal‐regulated kinase (ERK) promotes proliferation, metastasis, and poor survival in cancers of the breast, lung, liver. Advanced localized renal cell carcinoma (RCC) is extraordinarily treatment resistant has high recurrence rates despite surgery. Limited data exist regarding prognostic significance activated (phosphorylated) ERK RCC. The authors hypothesized that (pERK) disease progression metastasis RCC may be value as a biomarker to predict...