A5049952845- Mesenchymal stem cell research
- Wound Healing and Treatments
- Body Contouring and Surgery
- Effects of Radiation Exposure
- Reconstructive Surgery and Microvascular Techniques
- Dermatologic Treatments and Research
- Electrospun Nanofibers in Biomedical Applications
- Nonmelanoma Skin Cancer Studies
- Breast Cancer Treatment Studies
- Analytical Methods in Pharmaceuticals
- Tissue Engineering and Regenerative Medicine
- Analytical Chemistry and Chromatography
- Breast Implant and Reconstruction
- Cutaneous Melanoma Detection and Management
- Antibiotics Pharmacokinetics and Efficacy
- Nail Diseases and Treatments
- Bariatric Surgery and Outcomes
- Acute Kidney Injury Research
- Lymphatic System and Diseases
- Spinal Dysraphism and Malformations
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Sympathectomy and Hyperhidrosis Treatments
- Chemotherapy-related skin toxicity
- Trauma, Hemostasis, Coagulopathy, Resuscitation
University of Chicago
2023-2025
Dairy Management
2023
Stanford University
2019-2021
Stanford Medicine
2019-2020
Creative Commons
2019
Clinical Pharmacology of Miami
2019
Palo Alto University
2019
Institute for the International Education of Students
2019
University of Illinois Chicago
2018-2019
Illinois College
2019
JUN drives scarring by modifying the roles of fibroblast subpopulations, and antagonism via CD36 may represent an antiscarring therapy.
Abstract Background Free flap reconstruction in the setting of lower extremity trauma continues to be a challenging clinical problem fraught with high risk complications including compromise. Although studies have described certain factors that predispose these patients poor outcomes, there remains paucity literature detailing frailty as factor. As such, aim our study was examine application 5-item modified index (mFI-5) undergoing free reconstruction. Methods The 2012 2020 American College...
Radiotherapy (RT) helps cure and palliate thousands of patients with a range malignant diseases. A major drawback, however, is the collateral damage done to tissues surrounding tumor in radiation field. The skin subcutaneous tissue are among most severely affected regions. Immediately following RT, may be inflamed, hyperemic, can form ulcers. With time, dermis becomes progressively indurated. These acute chronic changes cause substantial patient morbidity, yet there few effective treatment...
Abstract Radiation therapy can result in pathological fibrosis of healthy soft tissue. The iron chelator deferoxamine (DFO) has been shown to improve skin vascularization when injected into radiated tissue prior fat grafting. Here, we evaluated whether topical DFO administration using a transdermal drug delivery system and immediately following irradiation (IR) mitigate the chronic effects radiation damage skin. CD-1 nude immunodeficient mice were split four experimental groups: (1) IR alone...
Abstract Fat grafting can reduce radiation-induced fibrosis. Improved outcomes are found when fat grafts enriched with adipose-derived stromal cells (ASCs), implicating ASCs as key drivers of soft tissue regeneration. We have identified a subpopulation positive for CD74 enhanced antifibrotic effects. Compared to CD74− and unsorted (US) ASCs, CD74+ increased expression hepatocyte growth factor, fibroblast factor 2, transforming β3 (TGF-β3) decreased levels TGF-β1. Dermal fibroblasts incubated...
Abstract The aim of this study was to explore the therapeutic effects fat grafting on radiation-induced hind limb contracture. Radiation therapy (RT) is used palliate and/or cure a range malignancies but causes inevitable and progressive fibrosis surrounding soft tissue. Pathological may lead painful contractures which limit movement negatively impact quality life. Fat able reduce reverse tissue fibrosis. We explored whether could improve extensibility in irradiated contracted limbs mice....
Objective: Radiation therapy is commonplace for cancer treatment but often results in fibrosis and atrophy of surrounding soft tissue. Decellularized adipose matrices (DAMs) have been reported to improve these tissue defects through the promotion adipogenesis. These are decellularized by a combination physical, chemical, enzymatic methods minimize their immunologic effects while promoting regenerative effects. In this study, we aimed at exploring ability DAM (renuva®; MTF biologics, Edison,...
Abstract Fat grafting is a surgical technique able to reconstruct and regenerate soft tissue. The adipose-derived stromal cells (ASCs) within the vascular fraction are believed drive these beneficial effects. ASCs increasingly recognized be heterogeneous group, comprised of multiple stem progenitor subpopulations with distinct functions. We hypothesized existence an ASC subpopulation enhanced angiogenic potential. Human that were CD34+CD146+, CD34+CD146−, or CD34+ unfractionated (UF)...
Breast capsular contracture is a major problem following implant-based breast reconstruction, particularly in the setting of radiation therapy. Recent work has identified fibrogenic fibroblast subpopulation characterized by CD26 surface marker expression.This aimed to investigate role CD26-positive fibroblasts formation implant capsules therapy.Breast capsule specimens were obtained from irradiated and nonirradiated breasts 10 patients bilateral mastectomy unilateral irradiation at time...
Radiation therapy is effective for cancer treatment but may also result in collateral soft tissue contracture, contour deformities, and non-healing wounds. Autologous fat transfer has been described to improve architecture function of radiation-induced fibrosis these effects be augmented by enrichment with specific adipose-derived stromal cells (ASCs) enhanced angiogenic potential. CD34+CD146+, CD34+CD146-, or CD34+ unfractionated human ASCs were isolated flow cytometry used supplement...
Two simple, accurate, specific, and precise chromatographic methods, reversed phase high-performance liquid chromatography (RP-HPLC) highperformance thin-layer (HPTLC), have been developed validated for the determination of moxifloxacin hydrochloride difluprednate in ophthalmic dosage form according to International Conference on Harmonization (ICH) guidelines. The separation HPLC was performed reverse (C18, 5 μm, 250 × 4.6 mm) column using isocratic condition, with acetonitrile, mM disodium...
Two-stage revision total knee arthroplasty (TKA) is the standard of care for prosthetic joint infections. The first stage involves removal infected prosthesis and placement an antibiotic impregnated cement spacer; following a period ranging from 4 weeks to 6 months, spacer then removed replaced with permanent prosthesis. advantage this approach that spacers provide supratherapeutic levels in without toxic accumulation serum. However, it remains important physicians pharmacists be aware...
Patients with breast cancer treated mastectomy are more likely to develop upper extremity dysfunction compared those breast-conserving therapy. This study aimed identify and treatment characteristics that may be risk factors for development of in patients mastectomy.
A simple, precise and accurate stability-indicating high performance thin layer chromatographic method for estimation of repaglinide in bulk drug tablet formulation has been developed validated. The stationary phase used was HPTLC plates precoated with silica gel 60F254 using the mobile chloroform: methanol: ammonia (4.5:1.0:0.05 V/V/V). Densitometric analysis performed absorbance mode at 242 nm. showed compact bands RF value 0.31 ± 0.02. Linear Regression calibration data good linear...