A5070500848- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
- interferon and immune responses
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Cell Image Analysis Techniques
- Mosquito-borne diseases and control
- Protist diversity and phylogeny
- Biocrusts and Microbial Ecology
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Tardigrade Biology and Ecology
- Viral Infections and Outbreaks Research
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
Roche (United Kingdom)
2014-2017
Hexagon (United Kingdom)
2015
Institut Pasteur
2012
Inserm
2012
Génomes, biologie cellulaire et thérapeutiques
2007
Emory University
2004
Dengue virus (DV) is a mosquito-borne flavivirus that causes hemorrhagic fever in humans. In the natural infection, DV introduced into human skin by an infected mosquito vector where it believed to target immature dendritic cells (DCs) and Langerhans (LCs). We found productively infects DCs but not LCs. show here interactions between E protein, sole mannosylated glycoprotein present on particles, C-type lectin cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)...
Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study influence cell population context, determines a single cell's microenvironment, image-based RNAi screens. We developed comprehensive computational approach that employs Bayesian and multivariate methods at single-cell level. applied these 45 RNA interference screens various sizes, including 7 druggable genome 2 genome-wide screens, analysing 17...
ABSTRACT The C-type lectin DC-SIGN expressed on immature dendritic cells (DCs) captures human immunodeficiency virus (HIV) particles and enhances the infection of CD4 + T cells. This process, known as trans -enhancement T-cell infection, has been related to HIV endocytosis. It proposed that targets a nondegradative compartment within DCs DC-SIGN-expressing cells, allowing incoming persist for several days before infecting target In this study, we provide lines evidence suggesting...
Several functions required for the replication of influenza A viruses have been attributed to viral matrix protein (M1), and a number studies focused on region M1 designated "helix six." This contains an exposed positively charged stretch amino acids, including motif 101-RKLKR-105, which has identified as nuclear localization signal, but several suggest that this domain is also involved in such binding ribonucleoprotein genome segments (RNPs), membrane association, interaction with export...
A wide range of viruses, including many human and animal pathogens representing various taxonomic groups, contain genomes that are enclosed in lipid envelopes. These envelopes generally acquired the final stages assembly, as viruses bud from regions membrane infected cell at which virally encoded proteins have accumulated. The procure their membranes during this process mature particles 'pinch off' cellular membranes. Under most circumstances, initiation another round infection is dependent...
Abstract Tardigrades are among the most stress tolerant animals and survived even unassisted exposure to space in low earth orbit. Still, adaptations leading these unusual physiological features remain unclear. Even phylogenetic position of this phylum within Ecdysozoa is Complete genome sequences might help address questions as genomic can be revealed reconstructions based on new markers. Here, we present a first draft species from family Milnesiidae, namely Milnesium tardigradum . We...
Background Immunocompromised patients are at greater risk of complicated influenza and may be more likely to develop antiviral resistance. This observational sub-study the Influenza Resistance Information Study (NCT00884117) aimed study resistance in immunocompromised with characterize its effect on clinical virological outcomes. Methods Eligible were aged ≥1 year a local rapid diagnostic or PCR test positive for ≤96 h after diagnosis symptoms. Nasal throat swabs taken RT-PCR analysis day 1...