A5073785226- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Allergic Rhinitis and Sensitization
- Corneal surgery and disorders
- Hematopoietic Stem Cell Transplantation
- Retinal Diseases and Treatments
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Optical Coherence Tomography Applications
- Toxoplasma gondii Research Studies
- Digital Imaging for Blood Diseases
- Electrospun Nanofibers in Biomedical Applications
- Nasal Surgery and Airway Studies
- melanin and skin pigmentation
- Salivary Gland Disorders and Functions
- Urticaria and Related Conditions
- Systemic Sclerosis and Related Diseases
- Hormonal Regulation and Hypertension
- Cell death mechanisms and regulation
Keio University
2020-2025
Keio University Hospital
2021-2025
Minamiaoyama Eye Clinic
2024
Shimizu (Japan)
2024
Fujita Health University
2024
Oduduwa University
2023
Tokyo Dental College Ichikawa General Hospital
2023
Abstract The use of artificial intelligence (AI) in the diagnosis dry eye disease (DED) remains limited due to lack standardized image formats and analysis models. To overcome these issues, we used Smart Eye Camera (SEC), a video-recordable slit-lamp device, collected videos anterior segment eye. This study aimed evaluate accuracy AI algorithm estimating tear film breakup time apply this model for DED according Asia Dry Society (ADES) diagnostic criteria. Using retrospectively corrected 158...
Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and lose function due to resultant fibrosis. An abnormal immune response thought be major factor in development of chronic ocular GVHD, which currently treated primarily with immunosuppressive therapies. However, all treatments yield unsatisfactory outcomes,...
In ophthalmology, the availability of many fundus photographs and optical coherence tomography images has spurred consideration using artificial intelligence (AI) for diagnosing retinal optic nerve disorders. However, AI application anterior segment eye conditions remains unfeasible due to limited standardized analysis models. We addressed this limitation by augmenting quantity a video-recordable slit-lamp device. then investigated whether our proposed machine learning (ML) algorithm could...
Systemic administration of Janus kinase (JAK) inhibitors is effective in treating chronic graft-versus-host disease (cGVHD) but associated with side effects. Topical drug effectively minimizes We aimed to investigate potential trends the efficacy topical delgocitinib a mouse model. Allogenic bone-marrow transplantation (BMT) was performed from B10.D2. BALB/c mice, leading sclerodermatous GVHD. GVHD mice were treated eye drops or ointment samples analyzed at 4 weeks post-BMT. and eye-drop...
This study assessed the anterior chamber depth (ACD) and iridocorneal angle using a portable smart eye camera (SEC) compared to conventional slit-lamp microscope anterior-segment optical coherence tomography (AS-OCT). retrospective case-control included 170 eyes from 85 Japanese patients. The correlation between ACD evaluations conducted with SEC was high (r = 0.814). Van-Herick Plus grade obtained two devices also 0.919). A kappa value observed for grading (Kappa 0.757). moderate measured...
Purpose: This study aimed to demonstrate the efficacy of a “Smart Eye Camera (SEC)” in comparison with conventional slit-lamp microscope by evaluating their diagnostic functionality for dry eye disease (DED) clinical cases. Methods: retrospective included 106 eyes from 53 adult Japanese patients who visited Ophthalmology outpatient clinics Keio University Hospital June 2019 March 2020. Tear film breakup time (TFBUT) and corneal fluorescence score (CFS) measurements diagnosis DED were...
Background: The incidence of allergic conjunctival diseases (ACDs) is gradually increasing worldwide. Both ophthalmologists and non-ophthalmologists prescribe eye drops to treat ACDs; however, there are many cases which treated without sufficient examination diagnosis the eyes. We have invented a portable, recordable, smartphone-attachable slit-lamp device—Smart Eye Camera (SEC). purpose this study was compare diagnostic abilities ACDs between SEC conventional, non-portable microscope....
To identify molecular signatures specific for ocular graft-versus-host disease (GVHD) by proteomic analysis of corneas from mice with GVHD.
Intravitreal ranibizumab (IVR) has been approved for treating diabetic macular edema (DME), and is used in daily clinical practice. However, the treatment efficacies of IVR monotherapy real-world settings are not well known. The medical records 56 eyes from 38 patients who received their first DME between April 2014 March 2015, were retreated with as needed no rescue treatment, such laser photocoagulation, retrospectively reviewed. course, best-corrected visual acuity (BCVA), fundus findings...
Chronic graft-versus-host disease (cGVHD) is one of the most frequent complications experienced after allogeneic hematopoietic stem cell transplantation. Reportedly, dysbiosis and severe damage to microbiome are also closely associated with GVHD. Herein, we aimed elucidate positive negative effects administration various antibiotics in a murine model cGVHD. For bone marrow transplantation (allo-BMT), from B10.D2 mice were transplanted BALB/c induce The cGVHD orally administered ampicillin,...
Graft-versus-host disease (GVHD) is a major complication after hematopoietic stem cell transplantation (HSCT), and ocular GVHD can cause severe dry eye that lead to visual impairment. Epithelial damage, vascular invasion, corneal fibrosis, perforation may occur in cases. It generally accepted inflammatory cells such as dendritic T contribute this pathological condition. However, it still unknown what condition occurs on the surface HSCT, when. We therefore observed dynamics of cornea chronic...
Primary angle closure glaucoma (PACG) is a major cause of visual impairment, particularly in Asia. Although effective screening tools are necessary, the current gold standard complex and time-consuming, requiring extensive expertise. Artificial intelligence has introduced new opportunities for innovation ophthalmic imaging. Anterior chamber depth (ACD) key risk factor been suggested as quick parameter PACG. This study aims to develop an AI algorithm quantitatively predict ACD from anterior...
Mesenchymal stem cells (MSCs) have been widely used in therapeutic applications for many decades. However, more and evidence suggests that factors such as the site of origin pre-implantation treatment a crucial impact on result. This study investigates role freshly isolated MSCs lacrimal gland after allogeneic transplantation. For this purpose, from transgenic GFP mice were transplanted into syngeneic recipients. While maintained spherical shape, engrafted tissue spindle-shaped interstitial...
<title>Abstract</title> Systemic administration of Janus kinase (JAK) inhibitors is effective in treating chronic graft-versus-host disease (cGVHD) but associated with side effects. Topical drug an approach minimizing these We aimed to demonstrate the efficacy topical delgocitinib a cGVHD mouse model. Allogenic bone-marrow transplantation (BMT) was performed from B10.D2. BALB/c mice, leading cGVHD. mice were treated eye drops or ointments; their samples analyzed 4 weeks post-BMT. ointment...
Background/Objectives: This study aimed to evaluate the impact of image enhancement techniques on interobserver reliability tear breakup time (TBUT), meniscus height (TMH), corneal fluorescein staining (CFS) scoring, and conjunctivochalasis detection using Smart Eye Camera (SEC), a portable device for anterior segment examination. Methods: A retrospective analysis was conducted video recordings captured by SEC from 46 patients with dry eye disease (DED). Three sets were created: unenhanced...
Background: This study aimed to evaluate the impact of image enhancement techniques on interobserver reliability tear break-up time (TBUT), meniscus height (TMH), corneal fluorescein staining (CFS) scoring, and conjunctivochalasis detection using Smart Eye Camera (SEC), a portable device for anterior segment examination. Methods: A retrospective analysis was conducted video recordings captured by SEC from 46 patients with dry eye disease (DED). Separate sets images were created each level...