A5058418962- Skin Protection and Aging
- Osteoarthritis Treatment and Mechanisms
- melanin and skin pigmentation
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
- TGF-β signaling in diseases
- Medicinal plant effects and applications
- Proteoglycans and glycosaminoglycans research
- Natural product bioactivities and synthesis
- Antioxidant Activity and Oxidative Stress
- Chemical Synthesis and Analysis
- Flavonoids in Medical Research
- Telomeres, Telomerase, and Senescence
- Dermatology and Skin Diseases
- Biochemical effects in animals
- Photodynamic Therapy Research Studies
- Metabolism, Diabetes, and Cancer
- Sesquiterpenes and Asteraceae Studies
- NF-κB Signaling Pathways
- Phytoestrogen effects and research
- Chemokine receptors and signaling
- Advanced Glycation End Products research
- Medicinal Plant Pharmacodynamics Research
- Muscle Physiology and Disorders
Pierre Fabre (France)
2010-2024
Université de Caen Normandie
1994-2004
Centre Hospitalier Universitaire de Caen
1994-2000
Inserm
1994-1995
ABSTRACT Hyaluronan (HA) is involved in wound healing and its biological properties depend on molecular size. The effects of native HA HA‐12 HA‐880 saccharide fragments human fibroblast proliferation expression matrix‐related genes were studied. three forms promoted cell adhesion proliferation. Matrix metalloproteinase‐1 ‐3 mRNA increased by all forms, whereas only stimulated the tissue inhibitor metalloproteinase 1. enhanced type I collagen transforming growth factor‐β (TGF‐β) 1 expression....
Abstract Skin aging has long been considered a purely cosmetic problem. However, as life expectancy increases, skin is taking on functional dimension that goes beyond cosmetics and appearance. Preventive or therapeutic strategies are needed to target cellular senescence, key process underlying the alterations in function appearance occur with aging, well address age‐related changes associated ‘dermatoporosis’ chronic insufficiency/fragility syndrome. Thus, given need for effective anti‐aging...
Intrinsic and extrinsic factors, including lifestyle sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) includes MMPs, CXCLs S100A8/9. Reducing SASP with senotherapeutics is promising strategy reduce Here we evaluated effect of formula containing niacinamide hyaluronic acid, are known limit senescence We conducted three different...
Objective Avocado and soya unsaponifiables (ASU) have been reported to exert beneficial effects in the treatment of periodontal osteoarticular diseases. They are supposed stimulate deposition repair extracellular matrix components, but mechanisms underlying their action not well understood. In view potential osteoarthritic (OA) cartilage role that transforming growth factor β (TGFβ) system could play process, we carried out vitro studies determine mechanism ASU on articular chondrocytes may...
Evaluation of the photoprotection provided by sunscreens is performed either through induction erythema and expressed as sun protection factor (SPF), or UVA-mediated persistent pigment darkening (PPD). None these two endpoints has a link with skin cancer, most deleterious consequence excess exposure to solar UV radiation. We thus set up complementary approach evaluate genome human skin. This based on quantification thymine cyclobutane dimer (TT-CPD), main DNA lesion induced both UVB UVA...
Abstract Objective To determine the effects of hypoxia and reoxygenation on metabolism chondrocytes their response to interleukin‐1β (IL‐1β). The study included activation hypoxia‐inducible factor 1 (HIF‐1), NF‐κB, activator protein (AP‐1) transcription factors, expression matrix components metalloproteases transforming growth β (TGFβ) TGFβ receptors, production nitric oxide (NO) prostaglandin E 2 (PGE ). Methods Bovine articular (BACs) were cultured confluency in either 5% O (hypoxia) or...
Natural aging of skin tissues, the addition cumulative action time and radiation exposure result in atrophy, wrinkles degeneration extracellular matrix (ECM). The aim study was to investigate beneficial effect a combination containing retinaldehyde (RAL), delta-tocopherol glucoside (delta-TC) glycylglycine ole-amide (GGO) dermocosmetic combination.The protective assessed through vitro gene expression ultraviolet (UV)-irradiated fibroblasts. A assay using UV light on ex vivo samples clinical...
Background/purpose The purpose of this clinical study was to identify suitable biomarkers for a better understanding the molecular and organizational changes in human dermis during intrinsic extrinsic ageing. Methods Sun‐exposed non‐exposed skin biopsies were collected from twenty‐eight women devised two groups (20‐30 ≥60 years old). hydric organization thermal transitions determined by Differential Scanning Calorimetry ( DSC ). Fourier Transform Infrared spectroscopy FTIR ) used absorption...
Abstract Background Specific sunscreens against ultraviolet ( UV ) A and B radiations are essential to prevent matrix degradation the activation of intracellular signaling pathways involved in photoaging photocarcinogenesis. Matrix results from UVA ‐induced production metalloproteinases MMP fibroblasts keratinocytes. In particular, keratinocytes, radiation induces β‐catenin nuclear translocation stimulates gene transcription. Our study was aimed at assessing efficacy a specific...
Abstract We have previously shown that TGF‐β1 exerts a bifunctional effect on RAC proliferation. Added to quiescent cultures, it inhibits the entry of G 0 /G 1 cells into S phase whereas in synchronized populations, stimulates DNA replication rate with delayed 2 + M and subsequent transient increase cell number. As TGF‐β2 β3 isoforms are also expressed bone cartilage tissues, was interest study their proliferation, comparison TGF‐β1. Using counting tritiated thymidine incorporation, we found...
Glycation is an aging reaction of naturally occurring sugars with dermal proteins. Type I collagen and elastin are most affected by glycation during intrinsic chronological aging.To study the in vitro ex vivo assays human skin cells explants antiaging effects glycylglycine oleamide (GGO).The antiglycation effect GGO was assessed a noncellular on and, vivo, immunohistochemical staining (elastin network glycation). The ability to contract fibroblasts functional assay, its anti-elastase...
The maintenance of articular cartilage integrity requires a balance between anabolic and catabolic processes which are under the control chondrocytes. These cells living in an anaerobic environment normally do not divide. They responsible for continuous extracellular matrix (ECM). Although multiple factors involved dynamic homeostasis cartilage, increases cytokines such as interleukin-1 (IL-1) associated with decrease synthesis increase degradation proteoglycans collagens. Conversely, growth...
Abstract Objective Skin ageing is linked to the accumulation of senescent cells and a “senescence‐associated secretory phenotype” (SASP). SASP factors include chemokines, cytokines, small extracellular vesicles (EVs) containing miRNAs. We characterized profile markers in normal human dermal fibroblasts (HDFs) evaluated effect Haritaki fruit extract on these senescence markers. Methods Senescence was induced HDFs by ionizing radiation (X ray), followed 14 days culture. Parallel incubations...