A5016013466- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Cannabis and Cannabinoid Research
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- interferon and immune responses
- Insect and Pesticide Research
- Forensic Toxicology and Drug Analysis
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
- Smoking Behavior and Cessation
- MicroRNA in disease regulation
- Calpain Protease Function and Regulation
- Pharmacological Receptor Mechanisms and Effects
- Neuroblastoma Research and Treatments
- RNA Research and Splicing
- Carcinogens and Genotoxicity Assessment
- Memory and Neural Mechanisms
University of California, Irvine
2020-2024
Exosomes are small extracellular vesicles (sEVs) of ~30-150 nm in diameter that enriched exosome marker proteins and play important roles health disease. To address large unanswered questions regarding biology
Abstract Maladaptive stress-related behaviors are integral to multiple complex psychiatric disorders, and it has been well established that serotonergic signaling mediates various aspects of these maladaptive states. In studies, we sought uncover the function a previously undefined pathway, which projects from interpeduncular nucleus (IPN) ventral hippocampus (vHipp). Intersectional retrograde chemogenetic viral manipulation strategies were employed manipulate IPN-vHipp pathway during...
The cholinergic system plays a crucial role in nervous function with important effects on developmental processes, cognition, attention, motivation, reward, learning, and memory. Nicotine, the reinforcing component of tobacco e-cigarettes, directly acts by targeting nicotinic acetylcholine receptors (nAChRs) brain. Activation nAChRs leads to multitude immediate long-lasting specific cellular populations, thereby affecting addictive properties drug. In addition direct actions nicotine binding...
ABSTRACT Exosomes are small extracellular vesicles (sEVs) of ∼30-150 nm in diameter that have the same topology as cell, enriched selected exosome cargo proteins, and play important roles health disease. To address large unanswered questions regarding biology vivo , we created exomap1 transgenic mouse model. In response to Cre recombinase, mice express HsCD81mNG, a fusion protein between human CD81, most highly yet described, bright green fluorescent mNeonGreen. As expected, cell...
Negative allosteric modulators, such as lynx1 and lynx2, directly interact with nicotinic acetylcholine receptors (nAChRs). The nAChRs are integral to cholinergic signaling in the brain have been shown mediate different aspects of cognitive function. Given interaction between lynx proteins these receptors, we examined whether endogenous negative modulators involved behaviors associated We found both cell-specific overlapping expression patterns lynx2 mRNA regions cognition, learning, memory,...
Abstract The opioid epidemic has led to a devastating loss of life nationwide. Of those dependent on opioids, many individuals desire quit or reduce use, but their efforts are often unsuccessful given the powerful reinforcing properties associated with drugs, especially fentanyl its high potency and speed onset. Here, we developed novel theraputic based newly artificial intelligence (AI)-based platform, which was rationally designed identify markers dysregulation from human drug user...
Abstract Medulloblastoma, the most common pediatric brain malignancy, has Sonic Hedgehog (SHH) and non-SHH group3 subtypes. MAGMAS (Mitochondrial Associated Granulocyte Macrophage colony-stimulating factor Signaling molecules) encode for mitochondrial import inner membrane translocase subunit is responsible translocation of matrix proteins across membrane. We previously reported that a small molecule inhibitor, BT9, decreases cell proliferation, migration, oxidative phosphorylation in adult...
Medulloblastoma is the most common malignant brain tumor in children. It has WNT-driven, SHH-driven/ TP53 mutant, wildtype, and non-WNT/non-SHH subgroups. MAGMAS (Mitochondrial Associated Granulocyte Macrophage colony-stimulating factor Signaling molecules) encodes a mitochondrial import inner membrane translocase subunit responsible for translocation of matrix proteins across membrane. We previously reported that small molecule inhibitor, BT9, decreases cell proliferation, migration,...
Cannabis is primarily consumed by smoking or vaping, which both result in pulmonary absorption of its psychotropic constituent, Δ9-tetrahydrocannabinol (THC), and thus faster onset action reduced liver metabolism compared to most other administration routes. Passive aerosol exposure THC has been shown mimic these features laboratory animals might provide an ecologically relevant model human cannabis inhalation. However, such studies have far overlooked the fact that rodents, unlike humans,...