A5016729265- Ultrasound Imaging and Elastography
- Cardiovascular Health and Disease Prevention
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- AI in cancer detection
- Ultrasonics and Acoustic Wave Propagation
- Ultrasound and Hyperthermia Applications
- Cerebrovascular and Carotid Artery Diseases
- Gene expression and cancer classification
- Non-Invasive Vital Sign Monitoring
- Flow Measurement and Analysis
- Advanced Nanomaterials in Catalysis
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Blood properties and coagulation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Image and Signal Denoising Methods
- Cancer Research and Treatments
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- RNA Interference and Gene Delivery
- Digital Imaging for Blood Diseases
- CRISPR and Genetic Engineering
- Luminescence and Fluorescent Materials
Sun Yat-sen University
2025
Fudan University
2024-2025
Kunming Medical University
2010-2024
Zhejiang University
2023-2024
Second Affiliated Hospital of Kunming Medical College
2010-2024
Guiyang Medical University
2023-2024
Guizhou University
2024
State Key Laboratory of Genetic Engineering
2024
National University of Singapore
2024
Sichuan Agricultural University
2020
Abstract Fluorescence imaging‐guided photodynamic therapy (FIG‐PDT) holds promise for cancer treatment, yet challenges persist in poor imaging quality, phototoxicity, and insufficient anti‐tumor effect. Herein, a novel nanoplatform, LipoHPM, designed to address these challenges, is reported. This approach employs an acid‐sensitive amine linker connect biotin‐modified hydrophilic polymer ( Biotin PEG) with new hydrophobic photosensitizer (MBA), forming OFF‐state P EG‐ M BA (PM) micelles via...
Elastography ultrasound (EUS) imaging is a vital modality. The current use of EUS faces many challenges, such as vulnerability to subjective manipulation, echo signal attenuation, and unknown risks elastic pressure in certain delicate tissues. hardware requirement also hinders the trend miniaturization equipment. Here we show cost-efficient solution by designing deep neural network synthesize virtual (V-EUS) from conventional B-mode images. A total 4580 breast tumor cases were collected 15...
Abstract We synthesize supramolecular poly(disulfide) (CPS) containing covalently attached cucurbit[7]uril (CB[7]), which is exploited not only as a carrier to deliver plasmid DNA encoding destabilized Cas9 (dsCas9), but also host include trimethoprim (TMP) by CB[7] moieties through the complexation form TMP@CPS/dsCas9. Once transfected into tumor cells CPS, presence of polyamines can competitively trigger decomplexation TMP@CPS, thereby displacing and releasing TMP from stabilize dsCas9...
The efficacy of photodynamic therapy is hindered by the hypoxic environment in tumors and limited light penetration depth. singlet oxygen battery (SOB) has emerged as a promising solution, enabling oxygen- light-independent 1O2 release. However, conventional SOB systems typically exhibit an "always-ON" release, leading to potential leakage before after treatment. This not only compromises therapeutic outcomes but also raises substantial biosafety concerns. In this work, we introduce...
The development of bioorthogonal activation in drug release represents a promising avenue for precise and safe anticancer treatment. However, two significant limitations currently hinder their clinical application: i) the necessity separate administration precursor its corresponding activator, leading to poor accumulation potential side effects; ii) reliance on exogenous metal or organic activators triggering activation, which often exhibit low efficiency systemic toxicity when extending...
Triple-negative breast cancer (TNBC) displays a highly aggressive nature that originates from small subpopulation of TNBC stem cells (TNBCSCs), and these TNBCSCs give rise to chemoresistance, tumor metastasis, recurrence. Unfortunately, traditional chemotherapy eradicates normal but fails kill quiescent TNBCSCs. To explore new strategy for eradicating TNBCSCs, disulfide-mediated self-assembly nano-prodrug can achieve the co-delivery ferroptosis drug, differentiation-inducing agent,...
Chemodynamic therapy (CDT) can induce cancer cell death through hydroxyl radicals (·OH) generated from Fenton or Fenton-like reactions. Compared with traditional therapies, CDT effectively overcomes inevitable drug resistance and exhibits low side effects. However, clinical application still faces challenges, primarily due to insufficient ·OH generation the short-lifetime of in vivo. To address these we developed a peroxynitrite (ONOO
Evidence on how beverage consumption modifies associations between air pollution (AP) exposure with the type 2 diabetes (T2D) risk remains scarce, which we aimed to investigate in this study. A total of 77,278 adults from UK Biobank cohort were enrolled. Annual average concentrations fine particulate matter (PM2.5 and PM10) nitrogen oxides (NO2 NOX) estimated represent long-term AP using land use regression model. The beverages (alcoholic beverages, juice, sugar-sweetened [SSB], coffee, tea)...
The present study aimed to understand the roles of hepcidin and iron metabolism in onset prostate cancer. cancer LNCap, PC3 DU145 cell lines were transfected with small interfering RNA (siRNA) targeting knockdown expression cells. levels normal RWPE-1cells detected by western blot analysis. Exogenous was added into hepcidin-silenced lines. Intracellular using a fluorescence assay, proliferative migratory capacities cells MTT wound-healing assays, respectively. apoptotic rate measured flow...
Cancer stem cells, characterized by high tumorigenicity and drug-resistance, are often responsible for tumor progression metastasis. Aldehyde dehydrogenases, overexpressed in cancer cells enriched tumors, present a potential target specific anti-cancer treatment. In this study, we report self-assembled nano-prodrug composed of aldehyde dehydrogenases activatable photosensitizer disulfide-linked all-trans retinoic acid diagnosis targeted treatment tumors. The can load with self-assemble into...
Ferroptosis can induce cell death that leverages Fe
The classroom is the core of school education, and evaluation teaching process great significance to improvement quality, performance students' behavior an important component evaluation. Real-time observation, processing analysis students in with information technology can not only remind standardize their classroom, help teachers manage but also reflect quality atmosphere improve methods. In this paper, we propose improved YOLOv3 target detection algorithm. By inserting attention mechanism...
Abstract We synthesize supramolecular poly(disulfide) (CPS) containing covalently attached cucurbit[7]uril (CB[7]), which is exploited not only as a carrier to deliver plasmid DNA encoding destabilized Cas9 (dsCas9), but also host include trimethoprim (TMP) by CB[7] moieties through the complexation form TMP@CPS/dsCas9. Once transfected into tumor cells CPS, presence of polyamines can competitively trigger decomplexation TMP@CPS, thereby displacing and releasing TMP from stabilize dsCas9...
Abstract Indoleamine 2,3‐dioxygenase 1 (IDO1), the key enzyme in catabolism of essential amino acid tryptophan (Trp) through kynurenine pathway, induces immune tolerance and is considered as a critical checkpoint, but its impacts metabolism on glucose lipid are overlooked. We aim to clarify potential role IDO1 aerobic glycolysis pancreatic cancer (PC). Analysis database revealed positive correlation PC between expressions genes encoding important glycolytic hexokinase 2 (HK2) , pyruvate...
A novel approach based on continuous wave (CW) Doppler ultrasound and the Hilbert-Huang transform with end-effect restraint by mirror extending is proposed to assess arterial distension. In approach, bidirectional signals were first separated using phasing-filter technique from mixed quadrature signals, which produced blood vessel wall movements. Each unidirectional signal was decomposed into intrinsic mode functions (IMFs) empirical decomposition end effect algorithm, then relevant IMFs...