A5101485946- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Clusterin in disease pathology
- Vascular Procedures and Complications
- Biomarkers in Disease Mechanisms
- Coronary Interventions and Diagnostics
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Parathyroid Disorders and Treatments
- Vasculitis and related conditions
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Computational Drug Discovery Methods
- Lipid metabolism and disorders
- Mechanical Circulatory Support Devices
- Intraperitoneal and Appendiceal Malignancies
- Endoplasmic Reticulum Stress and Disease
- Pericarditis and Cardiac Tamponade
- S100 Proteins and Annexins
- Ion channel regulation and function
- Neutropenia and Cancer Infections
- Central Venous Catheters and Hemodialysis
Capital Medical University
2019-2024
Shantou University
2024
Shantou University Medical College
2024
Longgang Central Hospital
2024
First Hospital of Shijiazhuang
2022-2023
Beijing Anzhen Hospital
2019-2023
Bethune International Peace Hospital
2011-2019
Novem (Netherlands)
2014
Fu Wai Hospital
2014
Thel-type Ca(2+)current (ICa,l) plays a crucial role in shaping action potential and is involved cardiac arrhythmia. Statins have been demonstrated to contribute anti-apoptotic anti-arrhythmic effects the heart. Here, we examined whether atorvastatin regulates theICa,land cell injury induced by angiotensin II (AngII) as well putative intracellular cascade responsible for effects. Cultured neonatal rat ventricular myocytes were incubated with AngII 24 h, then expression levels of...
Up-regulation of angiotensin II (AngII) occurs in cardiac diseases, such as congestive heart failure, hypertrophy, myocardial ischemia and atrial fibrillation, which represent major health problems. Evidence from vivo studies suggests that the level Apolipoprotein-J (ApoJ) is also elevated but plays a protective role cardiovascular disease. This study aimed to evaluate effects ApoJ against cytotoxicity AngII neonatal rat ventricular cells (NRVCs). In culture, NRVCs were damaged by exposure...
BACKGROUND:This study investigated the expression of BCL2 and BAX mRNA, inflammatory cytokines, interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), cardiac function in patients with chronic heart failure (CHF). The New York Heart Association (NYHA) Functional Classification measurement left ventricular ejection fraction (LVEF) evaluated function. MATERIAL AND METHODS:Patients CHF (n=60) due to coronary disease, hypertensive cardiomyopathy, healthy controls (n=30) were studied....
Management of symptomatic atrial tachycardia (AT) during pregnancy seems challenging, especially those originating from left appendage (LAA), which easily tend to be incessant and mediate cardiomyopathy. It's contradictory between therapy pregnancy. In this study, we report a case woman who presented with persistent AT, lead heart failure, early She underwent successful catheter ablation using CartoSound electroanatomic mapping without fluoroscopy. An electrophysiology (EP) study confirmed...
Background: Takayasu’s arteritis (TA) is a large-vessel vasculitis that predominantly affects the aorta, pulmonary artery, and its main branches. The cause of TA still unclear. Objective: To identify clinical characteristics at onset in different patient groups. Methods: manifestations, laboratory, angiographic findings 53 patients with based on age sex were retrospectively analysed. Results: ratio incidence males females was 1:4. Chest pain, reduced glomerular filtration rate (GFR),...
Oxidized low-density lipoprotein (ox-LDL) is crucial in cardiac injury. Apolipoprotein-J (ApoJ) contributes to antiapoptotic effects the heart. We aimed evaluate protective of ApoJ against ox-LDL cytotoxicity Neonatal rat ventricular cells (NRVCs). NRVCs were damaged by exposure ox-LDL, as shown increased caspase-3/7 activity, enhanced caspase-3 expression, and decreased cell viability. overexpression, using an adenovirus vector, significantly reduced ox-LDL-induced also prevented from...
Ovarian cancer is a prevalent malignant tumor of the female reproductive system, often remaining concealed until it reaches an advanced stage. The standard treatment protocol includes cytoreductive surgery for ovarian plus postoperative consolidation chemotherapy and maintenance therapy, although carries high recurrence rate. During period, can lead to bone marrow suppression, condition known as Chemotherapy-Induced Myelosuppression (CIM). This suppression may necessitate dose reduction or...
Previous studies have extensively investigated traditional predictors of cardiovascular disease (CVD) development, progression, and prognosis. However, the influence novel indicators such as Klotho, on CVD prevalence prognosis in general population remains unclear.
BACKGROUND This study investigated effects of exhaustive exercise on L-type calcium current (ICa,L) and the putative intracellular cascade responsible for effects. METHODS Rats were randomly divided into three treatment groups: sedentary (without exercise), exercised to exhaustion salubrinal injection before each period. Exercise group rats forced swim until time 9 days with 5% body weight attached head. Salubrinal (1 mg/kg) or an equivalent volume placebo solution (dimethyl sulfoxide) was...
Compared with traditional right ventricular apical pacing, His-bundle pacing (HBP) provides more physiologic by activating the normal conduction system. However, HBP has some limitations including higher thresholds. In addition, disease in distal His-Purkinje system may prevent correction of abnormal conduction. Left bundle branch (LBBP) overcome these disadvantages providing lower thresholds and relatively narrow QRS duration that improve cardiac function. Here, we describe a rare case...
To the editor: Radiofrequency ablation is an effective and relatively safe nonsurgical method for treatment of ventricular tachycardia (VT), its complications including cardiac perforations, tamponade, heart block, etc. Here, we report a patient who developed aortic rupture during ablation. A 71 years old woman presented to our department recurrent palpitation sustained 20 years, with low blood pressure, dizziness amaurosis. VT was diagnosed by ECG definitely (Figure 1A). We performed...
Introduction In the Chinese healthcare system, where there is overcrowding in hospitals, especially tertiary care centres, adoption of same-day discharge (SDD) post-percutaneous coronary intervention (PCI) could potentially lead to significant savings resources and costs. This study a non-inferiority trial examining whether post-PCI SDD feasible China. The primary hypothesis that patient outcomes post-urgent PCI patients are non-inferior regular patients. Methods analysis Post-Urgent...
Objective: Percutaneous coronary intervention (PCI) via the radial artery access has more advantages than that of femoral access, while or (and) brachial have tendency to be spasmodic. We sought investigate effectiveness and safety guiding catheter crossing over spasmodic segments by aid PCI wire balloon compared with traditional anti-spasmodic approach. Methods: The clinical data 168 patients disease (CAD) (group A), whose was performed spasm dissection passing through successfully were...
Background: Ventricular arrhythmias (VAs) originating from the middle interventricular septum (IVS) adjacent to atrioventricular annulus between His bundle (HB) and coronary sinus ostium (CSO) have not been characterized. Objective: To investigate electrophysiological characteristics ablation of these VAs. Methods: Twenty-eight VAs IVS HB CSO were studied. Results: The classified based on activation mapping, pace-mapping, response into those right endocardial side (n=9), intramural region...