A5067829468- Aquaculture disease management and microbiota
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Invertebrate Immune Response Mechanisms
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Medicinal Plants and Neuroprotection
- Probiotics and Fermented Foods
- Cancer-related gene regulation
- Respiratory and Cough-Related Research
- Single-cell and spatial transcriptomics
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Abdominal Trauma and Injuries
- Bacterial biofilms and quorum sensing
- Dental Health and Care Utilization
- Liver Disease and Transplantation
- Histone Deacetylase Inhibitors Research
- Oral microbiology and periodontitis research
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
Chinese Academy of Sciences
2020-2025
Zhejiang Cancer Hospital
2024
University of Science and Technology of China
2019-2023
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
National Clinical Research Center for Digestive Diseases
2023
Chung Shan Medical University Hospital
2022
University of Chinese Academy of Sciences
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2022
Hefei National Center for Physical Sciences at Nanoscale
2020-2021
Abstract Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol‐functionalized BP (BP‐PEG) nanosheets breast models. Using immunocompetent mouse models‐including 4T1 orthotopic BALB/c mice MMTV‐PyMT transgenic mice, it is found that BP‐PEG significantly inhibits tumor growth metastasis without...
Objective To examine the potential clinicopathological factors affecting prognosis of patients with gastric cancer after surgical treatment in China. Methods Between 1 January 2001 and 31 December 2012, a total 716 aged 22–84 years were enrolled study. Survival analysis techniques including log rank test Cox proportional hazard regression model applied to evaluate prognostic significance characteristics terms survival time. Results Of 24 demographic pathological variables collected data, 16...
Gastric cancer is a highly prevalent malignant neoplasm. Metabolic reprogramming intricately linked to both tumorigenesis and immune evasion. The advent of single-cell RNA sequencing technology provides novel perspective for evaluating cellular metabolism. This study aims comprehensively investigate the metabolic pathways various cell types in tumor normal samples at high resolution delve into intricate regulatory mechanisms governing activity cells gastric cancer.
This study explores the effect of preoperative radiotherapy combined with FOLFOX chemotherapy on patients locally advanced colon cancer (LACC). Data 102 LACC were retrospectively analyzed. All received surgical resection plus postoperative chemotherapy; whereas 58 underwent (CRT group, treatment group), 44 did not undergo (non-CRT group). Short- and long-term effects as well operative complications compared. The optical density values caudal-related homeobox transcription factor 2 inhibitor...
Gastric cancer (GC) is one of the deadliest cancers in world, with a 5-year overall survival rate lower than 20% for patients advanced GC. Genomic information now frequently employed precision treatment due to rapid advancements high-throughput sequencing technologies. As result, integrating multiomics data construct predictive models GC patient prognosis critical tailored medical care. In this study, we integrated design biological pathway-based gastric sparse deep neural network (GCS-Net)...
Abstract Taxanes are widely used in chemotherapy, but primary and acquired resistance limit the clinical efficacy. Studies have shown tumor interaction with macrophages microenvironment (TME) plays a significant role taxane resistance, yet therapeutic strategies that directly deplete or repolarize challenging considerable risk of side effects. Here we uncovered tumor-macrophage can be selectively targeted by inhibiting post-mitotic NOTCH2-JAG1 juxtacrine signaling TME, which strongly...
Porphyromonas gingivalis (P. gingivalis) is one of the keystone pathogenic bacteria periodontitis and peri-implantitis. This study aimed to investigate antibacterial effects molecular mechanisms trans-cinnamaldehyde (TC), a safe extract from natural plants, on P. gingivalis. Minimum inhibitory minimum bactericidal concentrations (MIC MBC) TC were determined, scanning transmission electron microscopies used assess morphological changes. The overall biomass was estimated, metabolic activity...
Sogatella furcifera is a destructive agricultural pest causing large threats to rice production in China and Southeast Asian countries. Despite recent breakthroughs long-read sequencing, high quality genomic data are very limited S. furcifera. In present study, chromosome-level assembly of the genome was completed (0.64 GB), comprising 15 chromosomes covered 95.04% estimated size, along with other 624 small scaffolds making up remaining 4.96% A total 24,669 protein-coding genes, 1211 long...
Gastric cancer is the fifth most common malignancy and third leading cause of cancer-related mortality worldwide. Immunotherapy offers promising new treatment options for gastric patients; however, it only effective in a limited fraction patients. In this study, we evaluated composition 22 tumor-infiltrating lymphocytes (TILs) TCGA Stomach Adenocarcinoma (STAD) using deconvolution-based method by analyzing publicly available bulk tumor RNA-seq data. The patients were classified into high-TIL...
Abstract: A 40-year old female patient from the Chinese Han population presented colorectal cancer (CRC) related symptoms including abdominal discomfort, tenesmus and severe back pain, was admitted to First Affiliated Anhui Medical University in October, 2008. The size of her tumor 3 cm × cm, carcinoma had invaded serosa layer, covering 3/4 intestine tube. She diagnosed with stage III CRC after examination. a good prognosis over 8-year survival curative surgery adjuvant therapy Oxaliplatin...
Gastric cancer is a leading cause of associated deaths worldwide and considered to be an age‑related disease. In younger patients, gastric biologically more aggressive, prognosis worse compared with that in elderly patients. the present case report, whole genome transcriptome was sequenced 26‑year‑old patient who presented cancer‑related symptoms admitted First Affiliated Anhui Medical Hospital (Hefei, China) December 2016. total, 9 germline 4 somatic mutations were identified...
Sogatella furcifera is an agricultural pest of great concern in China and Southeast Asian countries. However, the lack accurate complete reference genome resources has hindered understanding immunity evolution S. . Here, we utilized Nanopore sequencing to generate a chromosome-level assembly annotation (0.64 Gb), with GC content 34.25%. This comprised 15 chromosomes covering 95.04% estimated size, together additional 624 small scaffolds making up remaining 4.96% A total 24,669 protein-coding...
Abstract Taxanes are widely used in chemotherapy, but intrinsic and acquired resistance limit the clinical outcomes. Studies showed tumor interaction with suppressive macrophages plays a key role taxane resistance, yet therapeutic strategies that deplete or repolarize challenging. Here we uncovered novel tumor-macrophage via Notch2-Jag1 justacrine signaling can be targeted to sensitize paclitaxel response without affecting broad macrophage functions. Using translatome profiling, identified...