A5019254280- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Galectins and Cancer Biology
- Cancer Cells and Metastasis
- Caveolin-1 and cellular processes
- Liver Disease and Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Single-cell and spatial transcriptomics
- Inflammatory mediators and NSAID effects
First Affiliated Hospital of Anhui Medical University
2011-2024
Anhui Medical University
2011-2024
Fuyang Maternity and Child Health Care Hospital
2024
Abstract Background The tumor-promoting role of tumor microenvironment (TME) in colorectal cancer has been widely investigated biology. Cancer-associated fibroblasts (CAFs), as the main stromal component TME, play an important promoting progression and metastasis. Hence, we explored crosstalk between CAFs pathogenesis order to provide basis for precision therapy. Methods We integrated spatial transcriptomics (ST) bulk-RNA sequencing datasets explore functions CRC. In detail, single sample...
Abstract Background The therapeutic targeting of the tumor microenvironment (TME) in colorectal cancer (CRC) has not yet been fully developed and utilized because complexity cell–cell interactions within TME. further exploration these among tumor-specific clusters would provide more detailed information about communication networks with potential curative value. Methods Single-cell RNA sequencing, spatial transcriptomics, bulk sequencing datasets were integrated this study to explore...
Oxidative stress and ferroptosis exhibit crosstalk in many types of human diseases, including malignant tumors. We aimed to develop an oxidative stress- ferroptosis-related gene (OFRG) prognostic signature predict the prognosis therapeutic response patients with colorectal cancer (CRC). Thirty-four insertion genes between stress-related were identified as OFRGs. then performed bioinformatics analysis expression profiles 34 OFRGs clinical information obtained from multiple datasets. Patients...
Background: Integrin β superfamily members (ITGBs) are documented to play important roles in various biological processes, and accumulating evidence suggests that ITGBs associated with carcinogenic effects several malignancies. Gastric cancer (GC) is a complicated highly heterogeneous disease; however, the expression prognostic values of eight potential mechanism GC remain largely unclear. Methods: The significance were systematically analyzed through Gene Expression Profiling Interactive...
Objective To examine the potential clinicopathological factors affecting prognosis of patients with gastric cancer after surgical treatment in China. Methods Between 1 January 2001 and 31 December 2012, a total 716 aged 22–84 years were enrolled study. Survival analysis techniques including log rank test Cox proportional hazard regression model applied to evaluate prognostic significance characteristics terms survival time. Results Of 24 demographic pathological variables collected data, 16...
Gastric cancer (GC) is a widespread malignancy characterized by notably high incidence rate and an unfavorable prognosis. We conducted meticulous analysis of GC high-throughput sequencing data downloaded from the Gene Expression Omnibus (GEO) repository to pinpoint distinctive genes associated with GC. Our investigation successfully identified three signature implicated in GC, specific focus on barrier autointegration factor 1 (BANF1), which exhibits elevated expression across various types,...
Free portal pressure measurement is a reliable method for assessment of in patients with cirrhosis. Intrahepatic circulatory time analysis sonographic contrast agent can assess liver fibrosis and its severity. The purposes this pilot study were to the correlation between intrahepatic free whether be used predict venous severity.The measured 31 hepatitis B virus-related disease. Pearson was pressure.The hepatic vein-hepatic artery interval times significantly shorter hypertension group than...
Targeted therapies have improved the clinical outcomes of most patients with cancer. However, heterogeneity gastric cancer remains a major hurdle for precision treatment. Further investigations into tumor microenvironment are required to resolve these problems.
Background: Gastric cancer (GC) is the fifth most common malignancy and third leading cause of tumor-related deaths globally. Herein, we attempted to build a novel immune-related gene (IRG) signature that could predict prognosis immunotherapeutic efficiency for GC patients. Methods: The mRNA transcription data corresponding clinical were downloaded from Cancer Genome Atlas (TCGA) database as training group GSE84437 set testing cohort, followed by acquisition IRGs InnateDB resource ImmPort...
Although the location of proximal cancer remnant stomach is same as that primary stomach, its clinical characteristics and prognosis are still controversial.To evaluate clinicopathological features factors gastric stump (GSC) (PGC).From January, 2005 to December, 2016, 178 patients with GSC 957 cases PGC who received surgical treatment were enrolled. Patients in both groups underwent 1:1 propensity score matching analysis, pathological data systematically collected for statistical purposes....
Abstract: A 40-year old female patient from the Chinese Han population presented colorectal cancer (CRC) related symptoms including abdominal discomfort, tenesmus and severe back pain, was admitted to First Affiliated Anhui Medical University in October, 2008. The size of her tumor 3 cm × cm, carcinoma had invaded serosa layer, covering 3/4 intestine tube. She diagnosed with stage III CRC after examination. a good prognosis over 8-year survival curative surgery adjuvant therapy Oxaliplatin...
Gastric cancer is a leading cause of associated deaths worldwide and considered to be an age‑related disease. In younger patients, gastric biologically more aggressive, prognosis worse compared with that in elderly patients. the present case report, whole genome transcriptome was sequenced 26‑year‑old patient who presented cancer‑related symptoms admitted First Affiliated Anhui Medical Hospital (Hefei, China) December 2016. total, 9 germline 4 somatic mutations were identified...
Objective To study the expression of hypoxia-inducible factors-1α and pyruvate kinase type M2 in Hp infected gastric carcinoma their clinical significances. Methods The levels 85 cases tissues were detected by using RT-PCR immunohistochemical method. The Virulence level CagA gene tissue. Results As degree tumor differentiation, invasion depth stage increased, positive rate HIF-1α PKM2 two was correlation. HIF-1α(73%)was related to lymph node metastasis(χ2=4.204, P=0.041)....
Objective: To investigate the relationship between KDM6A mutation or expression and clinicopathological characteristics of gastric cancer. Methods: Fifty-seven cases cancer tissues were analyzed by second-generation sequencing, bioinformation database such as Cbioportal, Kaplan Meier-Plotter, Human Protein Atlas used to analyze Results: Among 57 samples, 14 mutation, proportion was 24.6%. Compared with non-mutation group, Borrmann classification, T stage, TNM stage tumor diameter mutant...