A5101896825- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Colorectal and Anal Carcinomas
- Nanoparticle-Based Drug Delivery
- Traditional Chinese Medicine Studies
- Metal complexes synthesis and properties
- Venous Thromboembolism Diagnosis and Management
- Tumors and Oncological Cases
- Helicobacter pylori-related gastroenterology studies
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
First Affiliated Hospital of Bengbu Medical College
2015-2024
Children's Hospital of Fudan University
2023
Soochow University
2016
Second Affiliated Hospital of Soochow University
2016
Tianjin University of Traditional Chinese Medicine
2013
The overexpression of pre-leukemia transcription factor 3 (PBX3) in tumors plays an important role invasion, metastasis and proliferation a variety human cancer types. Tumor angiogenesis significantly contribute to the progression create challenges for therapy. In present study, reverse transcription-polymerase chain reaction demonstrated that PBX3 was upregulated gastric (GC) tissues Transwell assay revealed promoted GC invasion vitro. addition, nude mouse xenograft model established, which...
Background: Pyroptosis plays a crucial role in immune responses.However, the effects of pyroptosis on tumor microenvironment remodeling and immunotherapy gastric cancer (GC) remain unclear.Patients Methods: Large-sample GEO data (GSE15459, GSE54129, GSE62254) were used to explore immunoregulatory roles pyroptosis.TCGA cohort was elucidate multiple molecular events associated with pyroptosis, risk score (PRS) constructed.The prognostic performance PRS validated using postoperative GC samples...
BACKGROUND:Endothelial progenitor cells (EPCs) play an important role in therapeutic angiogenesis. Besides, resveratrol (RSV) exerts many pharmacological functions regulation of cell function. Furthermore, microRNAs (miRNAs) have been considered to be great significance biological process. In this study, we aimed investigate the effect RSV on EPCs and its potential mechanism that involved recanalization venous thrombosis. MATERIAL AND METHODS:EPCs were treated with RSV, angiogenic was...
Multidrug resistance (MDR) is the primary cause for failure of chemotherapy in treatment colon cancer. Recent research has indicated that combination a chemotherapeutic agent and mitochondrial inhibitor might represent promising strategy to help overcome MDR. However, this approach be clinically effective, it important two drugs can actively simultaneously delivered into tumor cells at an optimal ratio completely released drug within cells. To address these challenges, we designed prepared...
Gastric cancer is one of the most common cancers and efficient therapeutic methods are limited. Further study exact molecular mechanism gastric to develop novel targeted therapies necessary urgent. We herein systematically examined that miR-204 suppressed both proliferation metastasis AGS cells. directly SOX4. In clinical tissue research, we determined was expressed much lower SOX4 higher in tissues compared with normal tissues. Associated analysis clinicopathological parameters patients...
To develop and externally validate a prognostic nomogram to predict overall survival (OS) in patients with resectable colon cancer.Data for 50,996 diagnosed non-metastatic cancer were retrieved from the Surveillance, Epidemiology, End Results (SEER) database. Patients assigned randomly training set (n = 34,168) or validation 16,828). Independent factors identified by multivariate Cox proportional hazards regression analysis used construct nomogram. Harrell's C-index calibration plots...
Gastric cancer is one of the most prevalent human cancers with poor prognosis. Trastuzumab a well-used targeted drug for gastric HER2 amplification. resistance restrains clinical use trastuzumab. In this study, we reported Gse1 coiled-coil protein (GSE1) promoted trastuzumab in HER2-positive cells. Acquired trastuzumab-resistant cells overexpressed GSE1, and depletion GSE1 decreased BCL-2 was downstream gene positively regulated by also performed promoting role A high level associated risk...
To investigate the potential role of GXYLT2 (glucoside xylosyltransferase 2) in gastric cancer (GC), TCGA (The Cancer Genome Atlas) database and Gene Expression Omnibus (GEO) dataset were used to evaluate mRNA expression, standardized mean difference diagnostic value comprehensively assessed. Survival analysis univariate/multivariate cox regression performed prognostic GC patients. The correlation between tumor immune cells was identified by using CIBERSORT algorithm. results showed that...
Most studies have found that right-sided colon cancer (RCC) has worse prognosis than left-sided (LCC), especially in stage III, but the reported of II is variable. This study aimed to evaluate impact tumor location on survival outcomes cancer.Patients with were identified Surveillance, Epidemiology, and End Results database from 2004 2009. The effect overall cancer-specific was analyzed using Cox proportional hazards regression models propensity score matching.Of 16,519 patients, 69.6% had...
Although the location of proximal cancer remnant stomach is same as that primary stomach, its clinical characteristics and prognosis are still controversial.To evaluate clinicopathological features factors gastric stump (GSC) (PGC).From January, 2005 to December, 2016, 178 patients with GSC 957 cases PGC who received surgical treatment were enrolled. Patients in both groups underwent 1:1 propensity score matching analysis, pathological data systematically collected for statistical purposes....
Gastric cancer (GC) ranks second in mortality among all malignant diseases worldwide. However, the cause and molecular mechanism underlying gastric are not clear. Here, we used integrated bioinformatics to identify possible key genes reveal pathogenesis prognosis of cancer.The gene expression profiles GSE118916, GSE79973, GSE29272 were available from Gene Expression Omnibus (GEO) database. Differentially expressed (DEGs) between GC normal tissues screened by R software Venn diagram software....
Introduction: Aim to find the efficacy treatment strategy for refractory/relapsed(r/r) patients with pediatric mature B-cell lymphoma (MBL) by summarizing outcome of 46 from Chinese Children's Lymphoma Multi-center Cooperation Group (CNCL). Methods: The MBL children treated 1 May 2017 31 December 2022 were enrolled. modified LMB89/96 protocol was adopted initial treatment. Clinical characteristics and risk factors analyzed r/r patients. Two groups after r/r: salvage chemotherapy (ICE...
Solitary fibrous tumor (SFT) derived from the abdominal wall is rare. We report a case of SFT in wall. When computed tomography reveals soft-tissue mass and analysis preoperative needle biopsy spindle cell tumor, possibility should be considered.
Abstract Background The effectiveness of neoadjuvant immune checkpoint inhibition (ICI) therapy has been confirmed by clinical trials; however, patients that are suitable for receiving this remain unspecified. Previous studies have demonstrated the tumor microenvironment (TME) dominates immunotherapy; therefore, an effective classification strategy TME is needed. Methods Five publicly available datasets (n = 1,426) were used to identify immunophenotypic features and screen core molecules....