A5028403326- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Hydrogen's biological and therapeutic effects
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Imaging and Diagnostics
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Cardiovascular Function and Risk Factors
- Cutaneous Melanoma Detection and Management
- Sinusitis and nasal conditions
- Tryptophan and brain disorders
- Inflammatory Biomarkers in Disease Prognosis
- Venomous Animal Envenomation and Studies
- Dermatology and Skin Diseases
- Cerebrovascular and Carotid Artery Diseases
- Nicotinic Acetylcholine Receptors Study
- Thyroid Cancer Diagnosis and Treatment
- Healthcare Systems and Public Health
- Cardiac Valve Diseases and Treatments
- Moyamoya disease diagnosis and treatment
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Atrial Fibrillation Management and Outcomes
- Ferroptosis and cancer prognosis
Shanghai Children's Medical Center
2024
Shanghai Jiao Tong University
2024
Beijing Children’s Hospital
2017-2024
Capital Medical University
2008-2024
Saitama Medical University
2005-2024
Tongji University
2017-2024
Tongji Hospital
2017-2024
Nanjing Medical University
2016-2023
MetroWest Medical Center
2021-2022
Nanjing Brain Hospital
2016-2021
Acute myocardial infarction (AMI) is characterized by high morbidity and mortality rates. Circular RNAs collectively participate in the initiation development of AMI. The purpose this study was to investigate role circRbms1 Ischemia-reperfusion (I/R) performed establish an AMI model. RT-qPCR Western blotting were detect mRNA analyze protein expression, respectively. interaction between miR-92a circRbms1/BCL2L11 confirmed luciferase RNA pull-down assays. overexpressed However, knockdown...
alpha-Synuclein has been implicated in the pathogenesis of Parkinson's disease (PD). Previous studies have shown that alpha-synuclein is involved regulation dopamine (DA) metabolism, possibly by down-regulating expression tyrosine hydroxylase (TH), rate-limiting enzyme DA biosynthesis. In this study, we constructed stably silenced MN9D/alpha-SYN(-) cells vector mediated RNA interference and examined its effects on metabolism. We found there were no significant differences TH protein mRNA...
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these and alter Th17/Treg balance airways. Tryptophan has long been suggested be relevant pathophysiology of allergic disorders, including asthma. Our study investigated whether metabolites are responsible changes decreases airway hyperreactivity inflammation seen during an asthma model. Ovalbumin was injected intraperitoneally into mice establish model, then high dose...
High expressions of galectin-3 were identified recently in the end stage amyotrophic lateral sclerosis (ALS) patients, which suggested that immune reactivity and inflammatory mechanisms might play an important role pathogenesis ALS. The purpose this study was to investigate plasma levels different groups stages ALS patients association with related clinical characteristics.A total 51 60 normal controls (NCs) recruited study. Plasma determined using enzyme-linked immunosorbent assay. Patients...
The pandemic of "Corona Virus Disease 2019" (COVID-19) has changed the lives people. There have been changes in common outpatient and emergency cases otolaryngology, so an analysis data pertaining to this was completed. This study is evaluate impact viral infection disease otolaryngological disease. uses diseases department during "COVID-19" (from February April 2020) same period past 3 years from Department Otolaryngology. During compared with last year, ranking by changed. Diseases such as...
Computational methods are employed to simulate the interaction of sea anemone toxin ShK in complex with voltage-gated potassium channel Kv1.3 from mice. All available 20 structures Protein Data Bank were considered for improving performance rigid protein docking ZDOCK. The traditional and novel binding modes obtained among a large number predicted complexes by using clustering analysis, screening expert knowledge, energy minimization, molecular dynamic simulations. quality validity resulting...
Normal brain function requires steady blood supply to maintain stable energy state. When the becomes suboptimal for a long period of time, chronic cerebral hypoperfusion (CCH) and variety changes may occur. CCH causes white matter injury cognitive impairment. The present study investigated effect nicotinamide (NAM) on CCH-induced impairment damage in mice. Male C57Bl/6J mice aged 10–12 weeks (mean age = 11 ± 1 weeks) weighing 24 - 29 g weight 26.5 2.5 g) were randomly assigned three groups...
Under-estimating the damage caused by trauma to dental structures may delay treatment. Timely and accurate diagnosis remains challenging in clinical practice. Radiography is an important modality for of traumatic injuries. The aim this study was compare efficacy periapical radiography cone beam computed tomography anterior maxillary dentoalveolar region children adolescents.Images patients who underwent both simultaneously because between January 2016 2020 were analyzed retrospectively....
Subcutaneous panniculitis T-cell lymphoma (SPTCL) is a rare, cytotoxic with which some patients have accompanying hemophagocytic syndrome (HPS). There currently no standard treatment regimen. In the past, most commonly used was multidrug chemotherapy. contrast, numerous case reports or small series suggest that immunosuppressive drugs could also be effective for patients. Since this NHL subtype extremely rare in children and adolescents, to improve understanding of disease standardize its...
δ-Dendrotoxin, isolated from mamba snake venom, has 57 residues cross-linked by three disulfide bridges. The protein shares a pharmacological activity with other animal toxins, the potent blockade of potassium channels, but is structurally unrelated to toxins different species. We employed alanine-scanning mutagenesis explore molecular mechanism δ-dendrotoxin binding using protein–protein docking and dynamic simulations. In our reasonable model δ-dendrotoxin–ShaKv1.1 complex, interacted...
The treatment of chronic rhinosinusitis (CRS) is often a difficult and long-term behavior, so it necessary to seek local method that can be used for long time, safe effective. Nasal saline irrigation after functional endoscopic sinus surgery (FESS) currently recognized as method, but has no anti-inflammatory, anti-damage, healing-promoting functions. To investigate the efficacy safety hydrogen-rich (HRS) nasal CRS surgery.
The purpose of this study is to survey the prevalence and morphology maxillary sinus septum, which might increase rate membrane perforation during floor elevation surgery, among northern Chinese, further analyze relationship between gender, age, edentulous type, septa.The cross-sectional retrospective was based on an analysis Cone Beam Computed Tomography (CBCT) images had been obtained from patients who visited radiology department Beijing Stomatology Hospital Capital Medical University...
Neurotensin receptor 1 (NTR1) is a neurotensin (NT) subtype with high affinity for NT. NT and NTR1 signaling are involved in modulating the dopamine system. Individual variations system have been demonstrated to determine certain dimensions of personality, but no studies thus far investigated involvement biological determination personality. We therefore examined this link Chinese Han population.We genotyped 3 single nucleotide polymorphisms (SNPs) (rs6090453C/G, rs6011914C/G, rs2427422A/G)...