A5002020686- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Peripheral Nerve Disorders
- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Anesthesia and Pain Management
Indiana University – Purdue University Indianapolis
2021-2022
University of Indianapolis
2021-2022
In-silico experiments used to optimize and inform how peripheral nerve based electrode designs perform hold the promise of greatly reducing guesswork with new as well number animals identify prove promising designs. Given adequate realism, in-silico offer identifying putative mechanisms that further exploration novel stimulation recording techniques their interactions bioelectric phenomena. However, despite using validated fiber models, when applied more complex case an implanted...
This paper describes a method to reversibly block nerve conduction through direct application of 1 Hz sinusoidal current waveform delivered bipolar cuff electrode. low frequency alternating (LFAC) was previously shown the effects vagal pulse stimulation evoked bradycardia in-vivo in anaesthetised rat model (Mintch et al. 2019). The present work measured effectiveness LFAC on larger caliber myelinated afferent fibers human sized bundles projecting changes breathing rate mediated by...
Electrical stimulation can be used to modulate activity within the nervous system in one of two modes: (1) Activation, where is added neural signalling pathways, or (2) Block, nerve reduced eliminated. In principle, electrical conduction block has many attractive properties compared pharmaceutical surgical interventions. These include reversibility, localization, and tunability for caliber type. However, methods effect are relatively new. Some have associated drawbacks, such as need large...
The sinusoidal low-frequency alternating current (LFAC) waveform was explored recently as a novel means to evoke nerve conduction block. In the present work, we whether increasing amplitude of LFAC results in fiber activation autonomic nerves. In-silico methods and preliminary work somatic nerves indicated potential frequency dependency on threshold activation. Hering-Breuer (HB) reflex used biomarker detect cervical vagus activation.Experiments were conducted isoflurane-anesthetized swine...