A5043701096- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Vagus Nerve Stimulation Research
- Conducting polymers and applications
- Nerve injury and regeneration
Purdue University West Lafayette
2021-2025
King Saud University
2021-2023
Direct electrical neurostimulation using continuous sinusoidal low frequency alternating currents (LFAC) is an emerging modality for neuromodulation. As opposed to the traditional rectangular pulse stimulation, there limited background on characteristics of peripheral nerves responses LFAC stimulation; especially within range (<50Hz). In this study, we demonstrate activation as a means activate motor by direct bipolar nerve stimulation via cuff electrodes, and characterize factors...
The stimulation and recording performance of implanted neural interfaces are functions the physical electrical characteristics interface, its electrode material structure. Therefore, rapid optimization such is becoming critical in most clinical research studies. This paper describes development an upgraded 3D printed cuff shell design containing a novel intrinsically conductive polymer (ICP) for peripheral nerve fibers.A stereolithography (SLA) printer was used to print scalable, custom...
This paper describes a method to reversibly block nerve conduction through direct application of 1 Hz sinusoidal current waveform delivered bipolar cuff electrode. low frequency alternating (LFAC) was previously shown the effects vagal pulse stimulation evoked bradycardia in-vivo in anaesthetised rat model (Mintch et al. 2019). The present work measured effectiveness LFAC on larger caliber myelinated afferent fibers human sized bundles projecting changes breathing rate mediated by...
Electrical stimulation can be used to modulate activity within the nervous system in one of two modes: (1) Activation, where is added neural signalling pathways, or (2) Block, nerve reduced eliminated. In principle, electrical conduction block has many attractive properties compared pharmaceutical surgical interventions. These include reversibility, localization, and tunability for caliber type. However, methods effect are relatively new. Some have associated drawbacks, such as need large...
The sinusoidal low-frequency alternating current (LFAC) waveform was explored recently as a novel means to evoke nerve conduction block. In the present work, we whether increasing amplitude of LFAC results in fiber activation autonomic nerves. In-silico methods and preliminary work somatic nerves indicated potential frequency dependency on threshold activation. Hering-Breuer (HB) reflex used biomarker detect cervical vagus activation.Experiments were conducted isoflurane-anesthetized swine...
Traditionally, electrical stimulation uses short duration (<1ms) charge balanced rectangular impulses to initiate action potentials. Although pulse provides an efficient means activate nerve fibers, the fibers are activated synchronously depolarizing edge of and favors large caliber resulting in inverse order recruitment. This study describes use low frequency alternating current (LFAC) using a pure tone continuous sinusoidal waveform evoke motor activation. In-silico in-vivo experiments...