A5061518061- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Vagus Nerve Stimulation Research
- Bone health and treatments
- Planarian Biology and Electrostimulation
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
Indiana University – Purdue University Indianapolis
2013-2025
University of Indianapolis
2019-2023
BioElectronics (United States)
2019
Direct electrical neurostimulation using continuous sinusoidal low frequency alternating currents (LFAC) is an emerging modality for neuromodulation. As opposed to the traditional rectangular pulse stimulation, there limited background on characteristics of peripheral nerves responses LFAC stimulation; especially within range (<50Hz). In this study, we demonstrate activation as a means activate motor by direct bipolar nerve stimulation via cuff electrodes, and characterize factors...
Signal transducer and activator of transcription 3 (Stat3) is a member the Stat family proteins involved in signaling many different cell types, including osteocytes. Osteocytes are considered major mechanosensing cells bone due to their intricate dendritic networks able sense changes physical force orchestrate response osteoclasts osteoblasts. We examined role Stat3 osteocytes by generating mice lacking these using Dmp-1(8kb)-Cre promoter (Stat3cKO mice). Compared age-matched littermate...
The intrinsic electrical material properties of the laminar components mammalian peripheral nerve bundle are important parameters necessary for accurate simulation interaction between fibers and neural interfaces. Improvements in accuracy these improve realism enables realistic screening novel devices used extracellular recording stimulation nerves. This work aims to characterize nerves build upon resistive parameter set established by Weerasuriya et al. 1984 amphibian somatic (frog sciatic...
Signal Transducer and Activator of Transcription 3 (STAT3) has recently been shown to be involved in bone development implicated diseases, such as Job's Syndrome. Bone growth changes have known for many years differ between sexes with male bones tending higher mass than female older females lose at faster rates males. Previous studies using conditional knock mice Stat3 specifically deleted from the osteoblasts showed both exhibited decreased mineral density (BMD) strength. Using Cre-Lox...
In-silico experiments used to optimize and inform how peripheral nerve based electrode designs perform hold the promise of greatly reducing guesswork with new as well number animals identify prove promising designs. Given adequate realism, in-silico offer identifying putative mechanisms that further exploration novel stimulation recording techniques their interactions bioelectric phenomena. However, despite using validated fiber models, when applied more complex case an implanted...
The stimulation and recording performance of implanted neural interfaces are functions the physical electrical characteristics interface, its electrode material structure. Therefore, rapid optimization such is becoming critical in most clinical research studies. This paper describes development an upgraded 3D printed cuff shell design containing a novel intrinsically conductive polymer (ICP) for peripheral nerve fibers.A stereolithography (SLA) printer was used to print scalable, custom...
Electrical stimulation can be used to modulate activity within the nervous system in one of two modes: (1) Activation, where is added neural signalling pathways, or (2) Block, nerve reduced eliminated. In principle, electrical conduction block has many attractive properties compared pharmaceutical surgical interventions. These include reversibility, localization, and tunability for caliber type. However, methods effect are relatively new. Some have associated drawbacks, such as need large...
Activation of nerve fibers using electricity has been known since antiquity. Methods to block propagating action potentials (AP) are a more recent discovery. This paper describes method reversibly conduction low frequency (1 Hz) alternating current (LFACb) waveform. An in situ electrophysiology setup was used assess the LFACb on APs within cervical vagus six anaesthetized Sprague-Dawley rats. Two sets Pt-Ir hook electrodes were used. The rostral electrode generate volley while waveform...
Finding a safe and effective method for blocking nerve fibers has been of particular interest researchers in recent years. This paper presents novel using low frequency alternating current to block fibers. Presented are examples phasic in-vivo earthworms, ex-vivo canine vagus in-silico simulations current. Using this onset activation, seen kilohertz block, is not seen. Blocking was achieved approximately 100 microamperes, some cases, as opposed milliamperes, reducing the possibility toxic...
Traditionally, electrical stimulation uses short duration (<1ms) charge balanced rectangular impulses to initiate action potentials. Although pulse provides an efficient means activate nerve fibers, the fibers are activated synchronously depolarizing edge of and favors large caliber resulting in inverse order recruitment. This study describes use low frequency alternating current (LFAC) using a pure tone continuous sinusoidal waveform evoke motor activation. In-silico in-vivo experiments...
The relative position of an indwelling electrode to the nerve fiber plays a critical role in shape single action potential (SFAP) detected by electrode. Parameters such as distance, path, and nodes Ranvier can have substantial influence on frequency content SFAP. This study explores effects these parameters simulated SFAPs within bundle with thin-film Longitudinal Intrafascicular Electrode (tfLIFE) longitudinally implanted at midline 2.4 mm diameter fascicle. were calculated for various...