A5061655533- Marine animal studies overview
- Fish biology, ecology, and behavior
- Congenital heart defects research
- Hearing, Cochlea, Tinnitus, Genetics
- Aquaculture disease management and microbiota
- Ichthyology and Marine Biology
- Craniofacial Disorders and Treatments
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Developmental Biology and Gene Regulation
- Axon Guidance and Neuronal Signaling
- Physiological and biochemical adaptations
- Tumors and Oncological Cases
- Metalloenzymes and iron-sulfur proteins
- Protist diversity and phylogeny
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Prenatal Screening and Diagnostics
- Antimicrobial Peptides and Activities
- Fish Ecology and Management Studies
- Invertebrate Immune Response Mechanisms
- Cancer-related molecular mechanisms research
- Amino Acid Enzymes and Metabolism
- Plant and Biological Electrophysiology Studies
- Chromosomal and Genetic Variations
Shanghai Ocean University
2014-2025
Fujian Medical University
2024
Ocean University of China
2006-2012
Observatoire Océanologique de Banyuls-sur-Mer
2012
Viruses are a leading cause of infectious diseases. Well-developed animal models valuable for understanding the immune responses to viral infections and pathogenesis Zebrafish is commonly used small vertebrate model organism with strong reproductive ability, short life cycle, rapid embryonic development. Moreover, zebrafish human genomes highly similar; they have approximately 70 % homology in protein-coding genes, 84 genes associated diseases counterparts. Recent years, different groups...
The lateral line system in fish is crucial for detecting water flow, which facilitates various behaviors such as prey detection, predator avoidance, and rheotaxis. cupula, a gelatinous structure overlaying the hair cells neuromasts, plays key role transmitting mechanical stimuli to cells. However, molecular composition of cupula matrix remains poorly understood. In this study, we found that Mucin-5AC, novel family mucin proteins, composed 2–27 cysteine-rich domains, presents cartilaginous...
Abstract Regenerative capacity varies significantly among species and across different organs. In mammals, the inner ear exhibits a limited ability to regenerate hair cells, whereas lateral line sensory organ of zebrafish demonstrates apparently limitless capability spontaneously cells following injury. However, specific cell populations representing stem in neuromast mechanism self-renewal remain unclear. this study, we show that mutation tnfrsfa led depletion organs impairment regeneration...
There has been growing interest in applying tissue engineering to stem cell-based regeneration therapies. We have previously reported that zebrafish can faithfully regenerate complicated structures through blastemal cell type conversions and reorganization. To unveil the regenerative factors arts of regeneration, we conducted transcriptomal analyses at four time points corresponding preamputation, re-epitheliation, formation, respecification. By combining hierarchical gene ontology term...
Abstract The skin mucus of fish acts as the first line self‐protection against pathogens in aquatic environment and comprises a number innate immune components. However, presence critical classical complement component C1q, which links adaptive systems mammalians, has not been explored primitive actinopterygian fish. In this study, we report that C1q is present Siberian sturgeon ( Acipenser baerii ). was able to inhibit growth Escherichia coli . bacteriostatic activity reduced by heating...
SNF2L encodes an ISWI chromatin remodeling factor that promotes gene transcription and is consistently elevated in cancers. Previous studies have shown inhibiting expression cancer cells leads to significant growth suppression, DNA damage, cell death. However, the underlying mechanisms remain poorly understood. In this study, we demonstrated lacking show significantly decreased glutathione (GSH) levels, leading reactive oxygen species (ROS) increased oxidative stress. deficiency also...
Abstract The electro‐receptive lateral line system appeared early in the evolutionary history of fish. Sturgeons, members primitive Chondrostei group, are known for their electroreceptors (ampullae Lorenzini) on head, which thought to be sensitive weak electric fields aquatic environments and involved feeding, mating migration. Here, we report results a set behavioral electrophysiological experiments designed determine function characteristics electrosense cultured sturgeons. showed Siberian...
Serine protease inhibitors, or serpins, are a group of widely distributed proteins with similar structures that use conformational change to inhibit proteases. Antithrombin (AT) is member the serine inhibitor superfamily and major coagulation in all vertebrates, but its evolutionary origin remains elusive. In this study we isolated for first time cDNA encoding an antithrombin homolog, BjATl, from protochordate Branchiostoma japonicum. The deduced protein BjATl consisted 338 amino acids...
The lateral line found in some amphibians and fishes has two distinctive classes of sensory organs: mechanoreceptors (neuromasts) electroreceptors (ampullary organs). Hair cells neuromasts can be damaged by aminoglycoside antibiotics they will regenerate rapidly afterward. Aminoglycoside sensitivity the capacity for regeneration have not been investigated ampullary organs. We treated Siberian sturgeon (Acipenser baerii) larvae with neomycin observed loss hair both organs labeling DASPEI...
Activin A receptor, type II (Acvr2) is a member of the transforming growth factor beta receptor family and can function as negative regulator skeletal muscle mass. Acvr2 plays an important role in regulating development that inhibit mice. However, there very little research reported on acvr2 teleost. In this study, we analyzed effect acvr2aa acvr2ba zebrafish. Growth rates WT acvr2a−/−b−/− were measured from juvenile stage to adult stage. addition, effects tested histological, protein...
Hemifacial microsomia (HFM) is a common birth defect involving the first and second branchial arch derivatives. Although several chromosomal abnormalities causal gene variants have been identified, genetic etiologies in majority of cases with HFM remain unknown. This study aimed to identify mutations affected individuals HFM.Whole-exome sequencing bioinformatics analysis were performed for 16 their family members. Sanger was applied confirmation selected mutations. Zebrafish embryos used...
Two full-length cDNAs, named CaM1a and CaM1b, encoding the highly conserved calmodulin1 (CaM1) proteins, were isolated from cDNA library of amphioxus Branchiostoma belcheri tsingtauense. There are only two nucleotide differences between them, producing one amino acid difference CaM1b. Comparison sequence CaM1 reveals that B. tsingtauense is identical with proteins floridae lanceolatum, Drosophila melanogaster CaM, ascidian Halocynthia roretzi CaMA mollusk Aplysia californica CaM1b differs at...
Fish detect water motions with their mechanosensory lateral line. The basic functional unit of the line is neuromast. In most fish species neuromasts are located in canals (canal neuromasts) or on skin (superficial neuromasts). this paper we describe system pufferfish, Takifugu obscurus. If threatened, inflates its body by sucking into esophagus. Pufferfish lack a canal but have directly open grooves. Each groove houses Tall, Medium, and Short Neuromasts, based height pedestal. One more...
Abstract Background The electrosensory ampullary organs (AOs) and mechanosensory neuromasts (NMs) found in sturgeon some other non-neopterygian fish or amphibians are both originated from lateral line placodes. However, these two sensory have characteristic morphological physiological differences. molecular mechanisms for the specification of AOs NMs not clearly understood. Results We sequenced transcriptome neomycin treated early regeneration stages, de novo assembled a transcriptome. By...