A5000548628- Elbow and Forearm Trauma Treatment
- Heterotopic Ossification and Related Conditions
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Kruppel-like factors research
- Tendon Structure and Treatment
- Inflammasome and immune disorders
- Orthopedic Infections and Treatments
- RNA modifications and cancer
- Hip disorders and treatments
- Refrigeration and Air Conditioning Technologies
- Genetic Syndromes and Imprinting
- Myofascial pain diagnosis and treatment
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Ferroptosis and cancer prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Osteoarthritis Treatment and Mechanisms
- Acute Ischemic Stroke Management
- Advanced Thermodynamic Systems and Engines
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Shoulder and Clavicle Injuries
Shanghai Jiao Tong University
2018-2025
Shanghai Sixth People's Hospital
2018-2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2021-2024
Yanbian University of Science and Technology
2024
Yanbian University
2024
Yanbian University Hospital
2023
Second Military Medical University
2020-2021
Shanghai University
2021
Eastern Hepatobiliary Surgery Hospital
2021
Lanzhou Jiaotong University
2020
Osteoarthritis (OA) is the most common disabling joint disease with no effective modifying drugs. Extracellular vesicles released by several types of mesenchymal stem cells could promote cartilage repair and ameliorate OA pathology in animal models, representing a novel therapeutic strategy. In this study, we demonstrated that extracellular derived from human umbilical cord (hUC-EVs) maintain chondrocyte homeostasis alleviate OA, further revealed molecular mechanism effect. miR-223, which...
The emerging three-dimensional (3D) printing technique has shown prominent advantages to fabricate hydrogel-based tissue scaffolds for the regeneration of bone defects. Here, a tough polyion complex (PIC) hydrogel was synthesized, and multiwalled carbon nanotubes (MWCNTs) were incorporated into PIC matrix form PIC/MWCNT biohybrid hydrogel, which manufactured 3D by extrusion-based defect repair. To best our knowledge, this is first study combine CNTs with hydrogels as results from in vitro...
Heterotopic ossification (HO) is one of the most intractable disorders following musculoskeletal injury and characterized by ectopic presence bone tissue in soft leading to severe loss function extremities. Recent studies have indicated that immune cell infiltration inflammation are involved aberrant formation. In this study, we found increased monocyte/macrophage mast accumulation during early HO progression. Macrophage depletion clodronate liposomes stabilization cromolyn sodium...
Abstract Heterotopic ossification (HO) represents an unwanted ossific wound healing response to the soft tissue injury which caused catastrophic limb dysfunction. Recent studies established involvement of inflammation and cellular senescence in process, though their role HO still remained be clarified. Here, a novel crosstalk where pyroptotic macrophages aroused tendon‐derived stem cells (TDSCs) is revealed encourage osteogenic during trauma‐induced formation. Macrophage pyroptosis blockade...
Primary hepatic cancer (PHC) is a common malignant tumor and the third most frequent cause of cancer-related death worldwide. However, molecular mechanisms underlying remain unknown.
Abstract Tendon injury is a common motor system disease, impairing joint mobility, and lowering quality of life. Once damaged, tendon has limited capacity for regeneration. Clinically, available therapeutic strategies have not achieved satisfactory outcomes. Chiral biomaterials can effectively regulate cell behaviors tissue healing, but been applied to injured yet. Here, chiral arginine attached electrospun membrane fabricate scaffolds. L‐chiral scaffold, rather than D‐chiral or R‐chiral...
Aims This study aimed to determine the minimal detectable change (MDC), clinically important difference (MCID), and substantial clinical benefit (SCB) under distribution- anchor-based methods for Mayo Elbow Performance Index (MEPI) range of movement (ROM) after open elbow arthrolysis (OEA). We also assessed proportion patients who achieved MCID SCB; identified factors associated with achieving MCID. Methods A cohort 265 treated by OEA were included. The MEPI ROM evaluated at baseline...
Abstract Heterotopic ossification occurs as a pathological condition characterized by ectopic bone formation within soft tissues following trauma. Vascularization has long been established to fuel skeletal during tissue development and regeneration. However, the feasibility of vascularization target heterotopic prevention remained be further clarified. Here, we aimed identify whether verteporfin widely used FDA‐approved anti‐vascularization drug could effectively inhibit trauma‐induced...
A schematic diagram of scaffold fabrication and implantation in vivo . The can effectively restore the ECM-like microenvironment improve quality nerve regeneration by controlled melatonin release.
The elbow is more susceptible to loss of motion after trauma than any other joint. Open arthrolysis often performed for posttraumatic stiffness if the does not improve with nonsurgical treatment, but midterm results this procedure and factors that may limit recovery have been widely studied.We reviewed patients who had undergone open hinged external fixator severe (ROM ≤ 60°) a minimum 5 years followup (1) analyze ROM gains; (2) assess functional improvement Mayo Elbow Performance Index...
Osteoarthritis (OA) is the most common disabling joint disease with no effective modifying drugs. Extracellular vesicles released by several types of mesenchymal stem cells could promote cartilage repair and ameliorate OA pathology in animal models, representing a novel therapeutic strategy. In this study, we demonstrated that extracellular derived from human umbilical cord (hUC-EVs) maintain chondrocyte homeostasis alleviate OA, further revealed molecular mechanism effect. miR-223, which...
Post-traumatic elbow stiffness is a disabling condition that remains challenging for upper limb surgeons. Open arthrolysis commonly used the treatment of stiff when conservative therapy has failed. Multiple questions arise from surgeons who deal with this disease. These include whether patient post-traumatic elbow, how to evaluate problem, surgery appropriate, perform an excellent arthrolysis, what optimal postoperative rehabilitation is, and prevent or reduce incidence complications....
Abstract Trauma‐induced heterotopic ossification (HO) is a complex disorder after musculoskeletal injury and characterized by aberrant extraskeletal bone formation. Recent studies shed light on critical role of dysregulated osteogenic differentiation in Krupel‐like factor 2 (KLF2) peroxisome proliferator‐activated receptor gamma (PPARγ) are master adapter proteins that link cellular responses to osteogenesis; however, their roles relationships HO remain elusive. Using murine burn/tenotomy...
Aims Heterotopic ossification (HO) is a common complication after elbow trauma and can cause severe upper limb disability. Although multiple prognostic factors have been reported to be associated with the development of post-traumatic HO, no model has yet able combine these predictors more succinctly convey information medical measures patients. Therefore, this study aimed identify leading formation HO surgery for trauma, establish validate nomogram predict probability in such particular...
Following trauma, the elbow is most susceptible to restricted motion among all joints. Open arthrolysis often performed for post-traumatic stiffness if that does not improve with non-operative management. However, optimal timing performing an open remains controversial. The purpose of this study was compare outcome (elbow and function) rate complications patients who had undergone early, median late release procedures establish time interval following injury, after which, effective can be...