A5100354870- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Asthma and respiratory diseases
- Analytical Chemistry and Sensors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Allergic Rhinitis and Sensitization
- Natural product bioactivities and synthesis
- Medical and Biological Ozone Research
- Supramolecular Chemistry and Complexes
- Urticaria and Related Conditions
- Phytochemicals and Antioxidant Activities
- Health, psychology, and well-being
- Per- and polyfluoroalkyl substances research
- Xenotransplantation and immune response
- Respiratory and Cough-Related Research
- Spine and Intervertebral Disc Pathology
- Protein Tyrosine Phosphatases
- Antiplatelet Therapy and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
Eulji University
2015-2024
Korea University
2009-2021
University of North Carolina at Chapel Hill
2020
Catholic University of Korea
2009
A new chemosensor-based approach to the detection of nitroaromatics is described. It involves analyte-induced quenching excimer emission a dipyrenyl calix[4]arene (L). The chemical and photophysical properties complexes formed between L mono-, di-, trinitrobenzene, di- trinitrotoluene were studied in acetonitrile chloroform by using (1)H NMR, UV/Vis, fluorescence spectroscopy. Fluorescence spectroscopy revealed that trinitroaromatics engendered largest response among various substrates...
Herein, we explore a new strategy in the chemo-sensor field for fluorescence amplification upon binding with metal ions based on controlled participation of nitrogen lone pair orbital. The basic architecture sensor entails fluorophore, sp2 hybridized (-C═N-), and chelator site referred to as control part. Though nonplanar nonfluorescent, compound IC1 achieved pseudo planarity from Zn2+ indicated by increased signal. Its other analogue (IC2) is also planar, unlike IC1-Zn2+ was fluorescent...
Memory T cells respond rapidly to repeated antigen exposure and can maintain their population for extended periods through self-renewal. These characteristics of memory have mainly been studied during viral infections, whereas existence functions in allergic diseases incompletely. Since patients suffer relapses caused by intermittent allergen exposure, we hypothesized that allergen- specific Th2 are present the factors necessary maintenance these provided lung airways. Using a murine model...
Abstract Thymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting eosinophilic inflammation numerous allergic diseases. Baicalein ( 1 ), a major component Scutellaria baicalensis , was found to be first small molecule block TSLP signaling pathways. It inhibited effectively eosinophil infiltration house dust mite-induced ovalbumin-challenged mouse models. Structure-activity relationship studies identified compound 11a...
Abstract Background Mastocytosis is characterized by a pathological increase in mast cells organs such as skin and bone marrow. Transglutaminase 2 ( TG 2) expressed contributes to allergic diseases, but its role mastocytosis has not been investigated. This study aimed investigate whether pediatric mastocytosis. Methods Serum, various tissues or marrow BM ) biopsy aspirates were obtained from normal control patients with indolent systemic SM ), mastocytoma, urticaria pigmentosa UP )....
Sang Hoon Kim, Hyun Woo Ho-jae Lee, Woong Jin Bae, Su Yeon Cho From the Department of Urology, The Catholic University Korea College Medicine, Seoul, Tuberculous granulomatous infection urinary tract is a rare complication intravesical Bacille Calmette-Guerin (BCG) immunotherapy, which commonly used for superficial urothelial cell carcinoma bladder. We present case tuberculous prostatic abscess in patient who had undergone BCG immunotherapy bladder situ. (Korean J Urol 2009;50:186-187)...
Carbon nanotubes (CNTs) are nanomaterials that have been employed in generating diverse materials.We previously reported CNTs induce cell death macrophages, possibly via asbestosis.Therefore, we generated CNT-attached polyvinylidene fluoride (PVDF), which is an established polymer membrane technology, and then examined whether PVDF immunologically safe for medical purposes compared to CNT alone.To test this, treated RAW 264.7 murine macrophages (RAW cells) with analyzed the production of...
Kyong Hoon Kim, Aryeong Choi, Sang Heonju Song, Seohoon Jin, Kyungim Jaebong Jang, Hanbyeul and Yong Woo Jung. Mol. Cells 2021;44:795-804. https://doi.org/10.14348/molcells.2021.0137
Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid development artificial using other animals. Although mini-pigs are candidate animals, contamination mini-pig T cells in may cause a major safety concern. Therefore, it is important analyze cross-reactivity IL-7, survival factor lymphocytes, between human, mouse, and mini-pig. Thus, we compared protein sequences IL-7 found that porcine was evolutionarily different from human IL-7. We also...
<h3>Background</h3> The efficacy of therapeutic cancer vaccines mainly depends on the selection neoantigen that can induce strong cytotoxic CD8 T-cell response required to reject tumors. Previously, we developed a prediction platform called 'VACINUS,' which predicts neoantigens based binding between tumor-reactive tumor-infiltrating lymphocytes (TILs) TCR and peptide-MHC(pMHC). In this study, investigated anti-tumor immune responses mediated by predicted VACINUS using mouse tumor model....
The purpose of this study was to compare the maximum strengths, flexor and extensor ratios, left right differences between isotonic strength(IRM) isokinetic peak torque at knee joint. subjects experiment were consisted early twenties male university students in Seoul Korea without disabilities. average age 21.70 with ±3.34 deviations. results shown as followed : 1. correlation test machines showed r=.676(p.001) on left, r=.600(p.01) right. Flexor r=.770(p.001) r=.674(p.001) significance...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
1. Introduction In this study, we report an innovative electrochemical aptasensor based on the labeling aptamer with quasi-direct electron transfer (quasi-DET)-type redox-enzyme, by developing a breakthrough technological platform to prepare one-to-one complex of enzyme and aptamer. The chronoamperometric-based is ideal sensor principle using aptamers for biomolecular recognition considering signal amplification labelled redox-enzyme. However, conventional methods label enzymes are chemical...