A5027378865- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Effects of Exercise
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Cardiomyopathy and Myosin Studies
- Pericarditis and Cardiac Tamponade
- Cardiac tumors and thrombi
- Public Administration and Political Analysis
- ECG Monitoring and Analysis
- Ultrasound and Hyperthermia Applications
- Intracranial Aneurysms: Treatment and Complications
- Viral Infections and Immunology Research
University Hospital Schleswig-Holstein
2016-2025
University of Lübeck
2016-2025
German Centre for Cardiovascular Research
2015-2023
Universitäres Kinderwunschzentrum Lübeck
2016-2023
University Hospital Cologne
2023
Japanese Circulation Society
2019
The Japanese Society of Gastroenterological Surgery
2019
Leipzig University
2009-2018
Leipzig Heart Institute
2009-2018
University Medical Center Hamburg-Eppendorf
2017-2018
Reduced electrogram amplitude has been shown to correlate with diseased myocardium. We describe a novel individualized approach for catheter ablation of atrial fibrillation (AF) based on low-voltage areas (LVAs) in the left atrium (LA). sought assess (1) incidence LVAs patients undergoing AF ablation, (2) distribution within LA, and (3) effect an strategy long-term rhythm outcomes.In 178 paroxysmal or persistent AF, LA voltage maps were created during sinus after circumferential pulmonary...
This randomized single-centre study sought to compare the efficacy and safety of pulmonary vein isolation (PVI) plus voltage-guided ablation vs. PVI with or without linear depending on type atrial fibrillation (AF). Overall, 124 ablation-naive patients paroxysmal persistent AF were (persistent AF) (paroxysmal additional (control group) low-voltage areas (LVAs) irrespective type. Bipolar voltage mapping was performed during stable sinus rhythm. An LVA consisted ≥ 3 adjacent points that each...
Background— Steerable sheath technology is designed to facilitate catheter access, stability, and tissue contact in target sites of atrial fibrillation (AF) ablation. We hypothesized that rhythm control after interventional AF treatment more successful using a steerable as compared with nonsteerable access. Methods Results— One hundred thirty patients paroxysmal or persistent drug-refractory undergoing their first ablation procedure were prospectively included randomized fashion 2 centers....
Takotsubo cardiomyopathy (TTC) can be accompanied by various life-threatening complications, including cardiogenic shock. The exact incidence and prognostic relevance of shock in TTC patients has not been studied detail.The frequency determinants were evaluated 178 with TTC. clinical course treatment strategies systematically analysed. Furthermore, short long-term mortality rates assessed a structured telephone follow-up.The this large population was 12.4%. Multivariable logistic regression...
To evaluate the prognostic value of intramyocardial haemorrhage (IMH) depicted by T2* imaging for risk stratification in ST-elevation myocardial infarction (STEMI) patients comparison with established cardiac magnetic resonance (CMR) prognosis markers.This multicentre study enrolled 264 reperfused within 12 h after symptom onset. CMR was performed first week STEMI to assess left ventricular function and infarct characteristics including IMH. The primary endpoint a composite death,...
Catheter ablation for atrial fibrillation (AF) treatment provides effective and durable pulmonary vein isolation (PVI) is associated with encouraging clinical outcome. A novel CF sensing temperature-controlled radiofrequency (RF) catheter allows very high-power short-duration (vHP-SD, 90 W/4 s) aiming a potentially safer, more faster ablation. We thought to evaluate preliminary safety efficacy of vHP-SD PVI utilizing catheter. The data was compared conventional power-controlled index (AI)...
The very high-power short-duration (vHP-SD) radiofrequency (RF) ablation concept of atrial fibrillation (AF) treatment by pulmonary vein isolation (PVI) aims for safer, more effective, and faster procedures. Utilizing conventional ablation, the 'close protocol' has been verified. Since lesion formation vHP-SD creates wider but shallower lesions we adapted close protocol to an individualized tighter 'very-close 3-4 mm inter-lesion distance (ILD) at anterior 5-6 posterior aspect left atrium...
Abstract Aims Simplified ablation technologies for pulmonary vein isolation (PVI) are increasingly performed worldwide. One of the most common complications following PVI vascular access-related complications. Lately, venous closure systems (VCSs) were introduced into clinical practice, aiming to reduce time bed rest, increase patients’ comfort, and The aim present study is compare safety efficacy using a VCS achieve haemostasis single-shot actual standard care [figure-of-eight suture manual...
Catheter ablation of atrial fibrillation (AF) is a highly invasive and relatively long-lasting procedure with specific requirements for patient sedation. The feasibility safety deep sedation described in prospective study 650 consecutive patients.Sedation was initiated an intravenous (iv) bolus midazolam, analgesia iv fentanyl bolus. After propofol bolus, maintenance achieved continuous administration guide dose 5 mg per kg hour. Heart rate, arterial blood pressure, oxygenation were...
Magnetic resonance imaging (MRI) in the context of electrophysiology (EP) studies facilitates visualization complex three-dimensional anatomy and underlying arrhythmogenic substrate, real-time passive catheters, atrial ventricular function complications, as well lesion during ablation without radiation. In following we report on our first experience a MRI-guided EP study demonstrating current possibilities drawbacks. Five consecutive patients (one male, four female; mean age 66 ± 11 years)...
Background— Data on left ventricular (LV) thrombus formation after primary percutaneous coronary intervention for ST-segment–elevation myocardial infarction (STEMI) are scarce. The aims of this study were to assess the (1) incidence LV thrombi using cardiac magnetic resonance in a multicenter cohort STEMI patients and (2) prognostic relevance at 1-year follow-up. Methods Results— In total, 738 reperfused by angioplasty enrolled 8 centers. Cardiac was completed within 1 week infarction....
Pulsed field ablation (PFA) is a non-thermal energy source with promising safety and efficacy advantages. We aimed to develop convenient, safe, effective fast method of pulmonary vein isolation (PVI) utilizing penta-spline PFA catheter via single femoral venous closure system.
Abstract Introduction Atrio‐esophageal fistula after esophageal thermal injury (ETI) is one of the most devastating complications available energy sources for atrial fibrillation (AF) ablation. Pulsed field ablation (PFA) uses electroporation as a new source catheter with promising periprocedural safety advantages over existing methods due to its unique myocardial tissue sensitivity. In preclinical animal studies, dose‐dependent temperature rise has been reported. TESO‐PFA registry...
Abstract Aims Catheter ablation with a cryoballoon (CB) provides effective and durable pulmonary vein (PV) isolation (PVI) associated encouraging clinical outcome data. The novel POLARx CB incorporates unique features, which may translate into improved safety, efficacy, outcomes. ICE-AGE-1 study aimed to assess the 1-year follow-up of in comparison Arctic Front Advance Pro (AF-CB4). Methods results A total 103 consecutive patients paroxysmal or persistent atrial fibrillation (AF) who...
AimsImplantable loop recorders (ILRs) with specific atrial fibrillation (AF) detection algorithms (ILR-AF) have been developed for continuous AF monitoring. We sought to analyse the clinical value of a new monitoring device and compare it serial 7-day Holter.
Background— Esophageal perforations are a rare but devastating complication of atrial fibrillation catheter ablation. Rapid treatment is crucial to avoid permanent disabilities and death. Surgical considered the choice. Alternatively, single case reports describe successful esophageal stenting, others discourage this approach because fatal consequences. Methods Results— We present 3 patients who developed esophagopericardial fistulas after radiofrequency ablation fibrillation. Diagnosis...
Experiences with novel oral anticoagulants (NOACs) early after atrial fibrillation (AF) catheter ablation are limited and show controversial results. We aimed to assess the longer-term safety, efficacy, acceptance of NOACs in a large real-world cohort patients presenting for AF ablation. From July 2010 until June 2012, 259 undergoing were prospectively included. Novel given at least 3 months post-ablation. Clinical outcome (stroke, thromboembolic events, major bleeding), adverse effects,...
To assess if real-time magnetic resonance (MR) imaging-guided radiofrequency (RF) ablation for atrial flutter is feasible in patients.The study complied with the Declaration of Helsinki and was approved by local ethics committee. All patients were informed about investigational nature procedures provided written consent. Ten (six men; mean age ± standard deviation, 68 years 10) symptomatic underwent isthmus ablation. In all patients, two MR imaging conditional steerable diagnostic catheters...
The left ventricular performance index (LVGFI) as a comprehensive marker of cardiac integrates LV structure with global function within one index. In prospective cohort study healthy individuals the LVGFI demonstrated superior prognostic value compared to ejection fraction (LVEF). patients after ST-segment elevation myocardial infarction (STEMI), however, role is unknown. Aim this was investigate relationship between and infarct characteristics well prognosis in large multicenter STEMI population.