A5054383760- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Syncope and Autonomic Disorders
- Connective tissue disorders research
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neural Engineering
- Venous Thromboembolism Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Bone and Dental Protein Studies
- Neurological and metabolic disorders
- Health Systems, Economic Evaluations, Quality of Life
- Heart Rate Variability and Autonomic Control
- Anesthesia and Sedative Agents
- Cerebral Venous Sinus Thrombosis
- Mesenchymal stem cell research
- Healthcare Technology and Patient Monitoring
- Phosphodiesterase function and regulation
- Protease and Inhibitor Mechanisms
TU Dresden
2014-2021
Danaher (United States)
2021
Abbott (United States)
2021
University Hospital Carl Gustav Carus
2020
Leipzig Heart Institute
2007-2019
Deutsches Herzzentrum der Charité
2017-2019
Christ University
2017-2019
Aarhus University Hospital
2018
Steinbeis Foundation
2015
Kantonsspital St. Gallen
2014
Reduced electrogram amplitude has been shown to correlate with diseased myocardium. We describe a novel individualized approach for catheter ablation of atrial fibrillation (AF) based on low-voltage areas (LVAs) in the left atrium (LA). sought assess (1) incidence LVAs patients undergoing AF ablation, (2) distribution within LA, and (3) effect an strategy long-term rhythm outcomes.In 178 paroxysmal or persistent AF, LA voltage maps were created during sinus after circumferential pulmonary...
Despite the advent of non-fluoroscopic technology, fluoroscopy remains cornerstone imaging in most interventional electrophysiological procedures, from diagnostic studies over ablation interventions to device implantation. Moreover, many patients receive additional X-ray imaging, such as cardiac computed tomography and others. More more complex procedures have risk increase radiation exposure, both for operators. The professional lifetime attributable excess cancer may be around 1 100...
Background: Optimal treatment of patients with persistent atrial fibrillation (AF) and heart failure (HF) reduced left ventricular ejection fraction (LVEF) an indication for internal defibrillator therapy is controversial. Methods: Patients persistent/longstanding AF LVEF ≤35% were randomly allocated to catheter ablation or best medical (BMT). The primary study end point was the absolute increase in from baseline at 1 year. Secondary points included 6-minute walk test, quality-of-life,...
The global, prospective AMPLATZER Amulet observational study documents real-world periprocedural, transoesophageal echocardiographic (TEE) and clinical outcomes from left atrial appendage occlusion (LAAO) using the device. aim of this report is to describe periprocedural early clinical/TEE results study.This multicentre registry included 1,088 patients (75±8.5 years, 64.5% male, CHA2DS2-VASc: 4.2±1.6, HAS-BLED: 3.3±1.1) with non-valvular fibrillation; 82.8% were considered have an absolute...
BACKGROUND: Clinically effective ablation approaches for patients with persistent atrial fibrillation (AF) are still being debated. So far, targets and strategies beyond pulmonary vein isolation (PVI) have failed to show systematic outcome improvement in randomized controlled clinical trials. METHODS: We conducted a multicenter, trial determine whether PVI plus individualized substrate of low-voltage myocardium improves AF. randomly assigned 324 1:1 ratio receive alone (163 patients; only)...
This randomized single-centre study sought to compare the efficacy and safety of pulmonary vein isolation (PVI) plus voltage-guided ablation vs. PVI with or without linear depending on type atrial fibrillation (AF). Overall, 124 ablation-naive patients paroxysmal persistent AF were (persistent AF) (paroxysmal additional (control group) low-voltage areas (LVAs) irrespective type. Bipolar voltage mapping was performed during stable sinus rhythm. An LVA consisted ≥ 3 adjacent points that each...
AimsIdentifying suitable candidates for circumferential left atrial pulmonary vein ablation (CPVA). CPVA is widely used as an strategy in patients with fibrillation (AF). Understanding the predictors of long-term success single catheter procedure AF based on can help to identify those who have a high risk recurrence this approach.
Recurrences of atrial fibrillation (AF) occur in up to 30% within 1 year after catheter ablation. This study evaluated the value CHADS2, R2CHADS2, and CHA2DS2-VASc scores for prediction rhythm outcomes AF ablation.Using Leipzig Heart Center Ablation Registry, we documented first 12 months 2069 patients (67% men; 60±10 years; 35% persistent AF) undergoing recurrences were defined as any arrhythmia occurring week (early recurrences, ERAF) between 3 (late LRAF) ERAF LRAF occurred 36% 33%,...
To describe the extent and distribution of low voltage zones (LVZ) in a large cohort patients undergoing ablation for paroxysmal persistent atrial fibrillation (AF), to explore baseline predictors LVZ these patients.Consecutive who underwent bipolar map guided AF ablation, were enrolled. Voltage maps conducted each patient using 3-dimensional electroanatomical mapping system defined as areas < 0.5 mV. A total 539 (309 male, age 65 ± 10 years) included. Low was present 58 out 292 with 134 247...
We sought to determine the relationship between size of left atrial isolated surface area (ISA) after pulmonary vein antrum isolation for paroxysmal fibrillation (AF) and rhythm outcome during a 12-month follow-up.One hundred one consecutive patients with AF (mean age, 59±11 years; median [range] history, 36 [24-96] months; mean size, 42±6 mm) were enrolled. The ISA was defined as ratio total antral excluding veins sum posterior wall area, while considering individual characteristics...
Despite the use of established 3D-mapping systems, invasive electrophysiological studies and catheter ablation require high radiation exposure patients medical staff. This study investigated whether electroanatomic tracking in prerecorded X-ray images on top an existing system has any impact exposure. Two hundred ninety-five consecutive were either ablated with guidance traditional CARTO-3 (c3) or help CARTO-UNIVU (cU): [typical atrial flutter (AFL) n = 58, drug refractory fibrillation (AF)...
To study device performance, arrhythmia recurrence characteristics, and methods of outcome assessment using a novel implantable cardiac monitor (ICM) in patients undergoing ablation for atrial fibrillation (AF). In 419 consecutive first-time catheter symptomatic paroxysmal (n = 224) or persistent 195) AF an ICM was injected at the end procedure. Telemedicine staff ensured full episode transmission coverage manually evaluated all automatic episodes. Device detection metrics were calculated...
Background— Esophageal perforations are a rare but devastating complication of atrial fibrillation catheter ablation. Rapid treatment is crucial to avoid permanent disabilities and death. Surgical considered the choice. Alternatively, single case reports describe successful esophageal stenting, others discourage this approach because fatal consequences. Methods Results— We present 3 patients who developed esophagopericardial fistulas after radiofrequency ablation fibrillation. Diagnosis...
Experiences with novel oral anticoagulants (NOACs) early after atrial fibrillation (AF) catheter ablation are limited and show controversial results. We aimed to assess the longer-term safety, efficacy, acceptance of NOACs in a large real-world cohort patients presenting for AF ablation. From July 2010 until June 2012, 259 undergoing were prospectively included. Novel given at least 3 months post-ablation. Clinical outcome (stroke, thromboembolic events, major bleeding), adverse effects,...
Until today, catheter interventional mapping and ablation of atrial fibrillation (AF) has been limited to the right left endocardium. We report feasibility, electrophysiological findings, clinical outcome using a combined endo-/epicardial approach for AF.Fifty-nine patients with permanence pulmonary vein isolation further symptomatic recurrences paroxysmal AF, persistent or tachycardia underwent reablation biatrial ablation. Identification arrhythmia substrates selection strategy were based...
A technological platform (MediGuide) has been recently introduced for nonfluoroscopic catheter tracking. No data on the safety of this technology are yet available in a large cohort patients.Data from prospective ablation registry were analyzed. All patients undergoing atrial fibrillation procedures supported by visualization included. Patient characteristics and procedural complications within first 3 months recorded. Between May 2012 February 2014, total 375 underwent using technology. The...
Surgical Ablation Related Reentrant Tachycardia Background Intraoperative atrial fibrillation (AF) ablation during cardiac surgery is a well‐established treatment. However, tachycardia mechanisms, strategies, and long‐term follow‐up of arrhythmias (AA) following intraoperative AF (AFA) have not been previously studied in large cohort patients. Objective Eighty‐two patients (48 male, median age 65 years) with symptomatic recurrence AA AFA underwent radiofrequency catheter ablation. Methods...
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies drug safety pharmacology. However, the electrophysiological pharmacological applications of hiPSC-CMs are hampered by manual patch-clamp technique, which is labor-intensive generates low output. The automated technique showing potential to overcome this problem. Here, we describe a new dissociation method, with can harvest...