A5100652271- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Microfluidic and Bio-sensing Technologies
- Micro and Nano Robotics
- 3D Printing in Biomedical Research
- Reproductive Health and Technologies
- Orbital Angular Momentum in Optics
- Cellular Mechanics and Interactions
- Image Processing Techniques and Applications
- Alzheimer's disease research and treatments
- AI in cancer detection
- Modular Robots and Swarm Intelligence
- Wound Healing and Treatments
- Hemostasis and retained surgical items
- Aluminum toxicity and tolerance in plants and animals
- Molecular Communication and Nanonetworks
- Piezoelectric Actuators and Control
- Advanced Neural Network Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Remote Sensing and LiDAR Applications
- Microfluidic and Capillary Electrophoresis Applications
- Curcumin's Biomedical Applications
- Substance Abuse Treatment and Outcomes
- Electrocatalysts for Energy Conversion
- Cardiovascular Effects of Exercise
Chinese University of Hong Kong, Shenzhen
2022-2025
Peking University
2025
Washington University in St. Louis
2025
Tianjin Medical University General Hospital
2022-2025
Shandong Academy of Agricultural Sciences
2024
Tianjin University of Technology
2021-2024
Shanxi Medical University
2023-2024
Weifang Medical University
2022-2023
China University of Petroleum, East China
2023
First Affiliated Hospital of Xinjiang Medical University
2023
Robotic micromanipulation is a relatively young field. However, after three decades of development and evolution, the fundamental physics; techniques for sensing, actuation, control; tool sets systems; and, more importantly, research community are now in place. This article reviews fundamentals robotic micromanipulation, including how micromanipulators end effectors actuated controlled, remote physical fields utilized visual servoing implemented under an optical microscope, force sensed...
Abstract A long-standing question in natural reproduction is how mammalian sperm navigate inside female reproductive tract and finally reach the egg cell, or oocyte. Recently, fluid flow was proposed as a long–range guidance cue for navigation. Coitus induces from oviduct to uterus align themselves against direction swim upstream, phenomenon termed rheotaxis. Whether rheotaxis passive process dominated by mechanics, actively sense adapt remains controversial. Here we report first...
Abstract Properties of organelles and intracellular structures play important roles in regulating cellular functions, such as gene expression, cell motility metabolism. The ability to directly interrogate inside a single for measurement manipulation has significant implications the understanding subcellular suborganelle activities, diagnosing diseases, potentially developing new therapeutic approaches. In past few decades, number technologies have been developed study single-cell properties....
Robotic manipulation of deformable objects has been a classic topic in robotics. Compared to synthetic such as rubber balls and clothes, biological cells are highly more prone damage. This article presents robotic for orientation control (both out-of-plane in-plane), which is required both clinical (e.g., vitro fertilization) biomedical clone) applications. manual cell based on empirical experience, the approach, modeling path planning, effectively rotates cell, while consistently...
In infertility treatment, blastocyst morphological grading is commonly used in clinical practice for evaluation and selection, but has shown limited predictive power on live birth outcomes of blastocysts. To improve prediction, a number artificial intelligence (AI) models have been established. Most existing AI only images the area under receiver operating characteristic (ROC) curve (AUC) achieved by these plateaued at ~0.65.This study proposed multimodal method using both patient couple's...
Magnetic micromanipulation has the advantage of untethered control, high precision, and biocompatibility recently undergone great advances. The magnetic task to tackle in this paper is three dimensionally navigate a 5-μm bead inside mouse embryo accurately apply forces intraembryonic structures perform mechanical measurements at multiple locations. Existing technologies are not able achieve these navigation measurement goals because poor force scaling and/or lacking capability applying an...
In clinical intracytoplasmic sperm injection (ICSI), a motile must be immobilized before insertion into an oocyte. This paper aims to develop robotic system for automated tracking, orientation control, and immobilization of sperms ICSI applications.We adapt the probabilistic data association filter by adding head state variables robustly tracking estimating tail positions under interfering conditions. The also utilizes motorized rotational microscopy stage new visual servo control strategy...
Mangiferin (MGF) is found in many natural plants, such as Rhizoma Anemarrhenae, and has anti-diabetes effects. However, its clinical applications development are limited by poor solubility low-concentration enrichment pancreatic islets. In this paper, targeted polymeric nanoparticles were constructed for MGF delivery with the desired drug loading content (6.86 ± 0.60%), excellent blood circulation, missile-like to pancreas. Briefly, Glucagon-like peptide 1 (GLP-1) an active targeting agent...
Abstract Background Studies on risk preferences have long been of great concern and examined the neural basis underlying risk‐based decision making. However, studies using conventional transcranial direct current stimulation ( tDCS ) revealed that bilateral could change propensity with limited evidence precisely focalized unilateral high‐definition HD ‐ ). The aim this experiment was to investigate effect focalizing left dorsal lateral prefrontal cortex DLPFC risk‐taking behavior during...
Measuring cell motility and morphology is important for revealing their functional characteristics. This paper presents automation techniques that enable automated, non-invasive measurement of parameters single sperm. Compared to the status quo qualitative estimation sperm's manually, provide quantitative data embryologists select a sperm intracytoplasmic injection. An adapted joint probabilistic association filter was used multi-sperm tracking tackled challenges identifying sperms intersect...
Understanding the internal mechanisms of transformer-based language models remains challenging. Mechanistic interpretability based on circuit discovery aims to reverse engineer neural networks by analyzing their processes at level computational subgraphs. In this paper, we revisit existing gradient-based identification methods and find that performance is either affected zero-gradient problem or saturation effects, where edge attribution scores become insensitive input changes, resulting in...
Ischemic stroke is a devastating neurological disease. Brain ischemia impairs systemic immune responses and heightens susceptibility to infections, though the underlying mechanisms remain incompletely understood. Natural killer (NK) cells exhibited decreased frequency compromised function after acute stage of stroke, resulting in NK cell-associated deficiency increased risk infection. MicroRNAs (miRNAs) are post-transcriptional molecular modulators. Our previous study revealed significant...
Objective Due to the nature of early termination treatment and transient lifestyles many people who use substances, providers are unaware factors that may have contributed their client’s engagement in treatment. Treatment researchers need a better understanding intrapersonal interpersonal impact recovery from clients’ perspective. This study uses qualitative methods explore these factors. Methods Eligible participants were adults had used opioids and/or stimulants receiving at consenting...
Spodumene (LiAlSi2O6) is a member of pyroxene-group minerals. It has the highest theoretical lithium abundance among all Li-bearing In present work, in situ high-pressure Raman spectroscopic investigation natural spodumene have been conducted up to 19.04 GPa. Unheated and recovered after heat treatments (up 1000 °C) also analyzed by X-ray diffraction infrared spectroscopy. The results indicate that spodumene, displacive C2/c–P21/c transformation triggered at ~3.2 GPa, remains stable...