A5056410315- Malaria Research and Control
- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Hemoglobin structure and function
- Hemoglobinopathies and Related Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Erythrocyte Function and Pathophysiology
- Immune responses and vaccinations
- Plant biochemistry and biosynthesis
- Bioactive Compounds and Antitumor Agents
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Phytochemical Studies and Bioactivities
- Drug-Induced Hepatotoxicity and Protection
- Blood Pressure and Hypertension Studies
- Phytoestrogen effects and research
- Global Health Care Issues
- Phytochemical and Pharmacological Studies
- Neonatal Health and Biochemistry
- Cancer-related Molecular Pathways
- Healthcare Systems and Reforms
Covenant University
2016-2024
University of Lagos
2022
Tulane University
2020-2021
East Carolina University
2021
Curcuma longa, popularly known as Turmeric, is a rhizomatous herbaceous perennial plant used in folk medicine for the treatment, prevention, and management of various illnesses such cancer, diabetes, Arthritis, diarrhoea, inflammation, psoriasis, hepatobiliary diseases, gastric peptic ulcers. This study reviewed ethnomedicinal potentials, phytochemicals, pharmacological activities C. longa. In vitro vivo studies reported that longa its major bioactive constituent (curcumin) possess...
Plasmodium falciparum Apicomplexan Apetala 2 Invasion ( PfAP2-I) transcription factor (TF) is a protein that regulates the expression of subset gene families involved in P. red blood cell (RBC) invasion. Inhibiting PfAP2-I TF with small molecules represents potential new antimalarial therapeutic target to combat drug resistance, which this study aims achieve. The 3D model structure was predicted ab initio using ROBETTA prediction tool and validated Save server 6.0 MolProbity. Computed Atlas...
Malaria eradication globally is yet to be achieved and transmission sustained in many endemic countries. Plasmodium falciparum continues develop resistance currently available anti-malarial drugs, posing great problems for malaria elimination. This study evaluates the frequencies of asymptomatic infection multidrug resistance-1 (mdr-1) gene mutations parasite isolates, which form basis understanding persistently high incidence South West, Nigeria.A total 535 individuals aged from 6 months...
Malaria importation is one of the hypothetical drivers malaria transmission dynamics across globe. Several studies on focused effect use conventional control strategies as approved by World Health Organization (WHO) but did not capture traditional vigilant humans. In order to handle aforementioned situation, a novel system Ordinary Differential Equations (ODEs) was developed comprising human and vector compartments. Analysis carried out assess its quantitative properties. The computational...
Reports of resistance to current antimalarial combination therapies (ACTs) have necessitated the discovery new drugs, most importantly with mechanisms action. From our molecular docking study, small molecule 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5 a]pyrido[4,3-d]pyrimidin-9(1H)-one (MCL) was identified be capable inhibiting an essential protein in Plasmodium falciparum (Apetala 2-invasion transcription factor) involved red blood...
Breast cancer is the world's most prevalent and accounts for lost disability-adjusted life years in women worldwide. Tumour-promoting inflammation sustained proliferative signaling are some hallmarks of which can be activated by environmental carcinogens that induce oxidative stress via increased interleukin-6 (IL-6) secretion. Increased binding estrogen promotes development proliferation breast cancer. Phytochemicals have been reported to promote health combating stress. This study aims...
The discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that houses housekeeping processes and metabolic pathways critical to Plasmodium parasites’ survival has prompted increased research on identifying potent inhibitors can impinge apicoplast-localised processes. is absent in humans, yet it proposed originate from the eukaryote’s secondary endosymbiosis primary symbiont. This symbiotic relationship provides favourable microenvironment for such haem...
The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring efficacy artemisinin-based combination therapies (ACTs). This post analyses is aimed to evaluate changes early treatment response markers 10 years after the adoption ACTs as first-line treatments uncomplicated Nigeria.At 14 sentinel sites six geographical areas Nigeria, we evaluated responses 1341 children under 5 additional 360 16...
This study was designed to explore the in vitro anticancer effects of bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves plant were extracted with ethanol and partitioned sequence petroleum ether, ethyl acetate, n-butanol. acetate fraction phytochemically studied using thin layer chromatography (TLC) column (CC). Structural elucidation pure obtained done mass spectra, 1H-NMR, 13C-NMR analysis. subsequently screened five different lines:...
The burden of hypertension, a silent killer, continues to increase in low- and middle-income countries. This study evaluated blood pressure (BP) healthy adults determine their risk developing hypertension reduce associated morbidity the disease. Overall, 182 subjects aged >16 years participated study. Systolic (SBP) diastolic (DBP) was measured after resting period using mercury sphygmomanometer. Random glucose (RBG) concentration also determined. Regression models were used high BP with...
The Olax subscorpioidea (Oliv) plant belongs to the Olacaceae family. It is a local remedy used in Nigeria treat wide range of conditions, including cancer. This study examined fractions and ethanol leaf extract for phytochemical content, antioxidant activity, cytotoxic activity. Using accepted methods, total tannin (TTC), flavonoid (TFC), phenolic (TPC) were assessed. activities determined through DPPH, ABTS, OH methods. lethality assay brine shrimp was determine ethyl acetate fraction...
Plasmodium falciparum, a malaria pathogen, has shown substantial resistance to treatment coupled with poor response some vaccines thereby requiring urgent, holistic, and broad approach prevent this endemic disease. Understanding the biology of parasite been identified as vital overcome threat malaria. This study is aimed at identifying essential proteins unique parasites using reconstructed iPfa genome-scale metabolic model (GEM) 3D7 strain falciparum by filling gaps in nineteen (19)...
The chronic effects of automobile paint fumes and their volatile organic constituents form detrimental air pollution with hazardous consequences especially to industrial workers the population within vicinity. This study investigated exposure in Mushin area Lagos, Nigeria. Fifty artisans employed painting industries were compared 50 control group whose work does not expose them fumes. Five milliliters blood was collected used for assessment hematological biochemical parameters. artisan...
The world is currently trending towards the discovery of foods that can also serve as nutraceuticals which are highly beneficial to human health. Fortification yoghurt with fresh tomato juice has shown incorporate lycopene into yoghurt, in turn, increased nutritional benefit yoghurt. Tomato was added increasing levels 0, 50, 100, 150 and 200 w/w% plain Ash, carbohydrate, moisture pH, viscosity content were all analyzed using standard methods. Results showed ash carbohydrate improved direct...
Objective: With increasing incidence of cancers globally and limited resources in some affected countries, repurposing existing drugs for reducing tumorigenesis is highly important. Artemisinin caffeine have potent anti-oxidative anti-tumor properties but are therapies other diseases. This study evaluated the biochemical p53 gene modulatory effects doses artemisinin-caffeine combination on breast, lungs liver tissues rats induced with DMBA. Methods: After due ethical approval, 30 animals...
National social health insurance scheme aims to improve the of citizens and provide equal access care across different income classes. This empirical datasets describes quality health, subscription, awareness, coverage benefits in socio-economic class workers Ota Lagos, Nigeria. The perception individual׳s state level satisfaction accessed are reported opinions on ways meet needs a developing country such as
Abstract Despite concerted efforts by the World Health Organization (WHO) to control malaria, it is still being diagnosed in patients visiting hospitals Tropical Countries of World. Hence, this study investigated risk factors responsible for malaria transmission dynamics through a hospital case study. Data that presented with from June 2019 December 2020 were acquired Covenant University Medical Centre Ota, South West Nigeria. Descriptive statistical analyses carried out so as examine...
Introduction: Plasmodium falciparum has developed resistance to artemisinin drugs in Southeast Asia, and its reduced sensitivity been reported other regions. This study aims determine parasite susceptibility the bioactive form of derivatives- dihydroartemisinin (DHA)-, detect K13 polymorphism isolates from an endemic area Nigeria. Methods: Ex-vivo response 55 parasites obtained malaria-positive patients were exposed pulse DHA concentration cultured for 66 hours ex-vivo. Parasite ring stage...
Breast cancer continues to be a major contributor cancer-related deaths in developing nations. Olax subscorpioidea is used Nigerian traditional medicine as treatment for cancer. The study examined the effects of subscorpioidea's ethyl acetate fraction (OSEA) and ethanol leaf extract (OSE) on 7,12-Dimethylbenz(α)anthracene (DMBA)-induced breast female Sprague-Dawley rats. anticancer, antioxidant anti-inflammatory activities extracts were evaluated using established procedures. involved 40...
Introduction: Olax subscorpioidea is a medicinal plant that Africans use to treat numerous ailments, including cancer. This research examines the antioxidant, anticancer, and in-silico properties of ethyl acetate fraction subscorpioidea’s (OSEA) on 7,12-Dimethylbenz(α) anthracene (DMBA)-induced cell proliferation in female rats. Methods: Forty Sprague Dawley rats averaging 110 ± 20 g were induced with DMBA (80 mg/kg) treated (250 mg/kg BW) O. or tamoxifen (6.6 before after induction. The...
In this study, immunoinformatics strategies were used to design a subunit vaccine against malaria from immunogenic regions of three Plasmodium falciparum surface antigens; liver stage antigen 3-C (V750-K1433), merozoite 180 truncate-4 (A805-P1093), and protein 10 region 1 (D29-N188). A multi-epitope construct (VC) was designed immunodominant B- T-cell epitopes followed by structure prediction, evaluation, validation. Toll-like receptors (TLRs) 2 4 docked with the VC. Their complexes’...
Background: Hemolysis is common in malaria infection and during the course of treatment. Previous studies have reported delayed post-artemisinin hemolysis occurring naïve immune individuals treated with parenteral or oral artemisinin-derivatives. This study aims to understand if occurs absence parasites underlying mechanisms for hemolytic effects after administration two antimalarial drugs malaria-free Wistar rats. Methods: Forty animals were randomized into 5 groups eight each; they...