A5005499743- Antifungal resistance and susceptibility
- Glycosylation and Glycoproteins Research
- Fungal Infections and Studies
- Tuberculosis Research and Epidemiology
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- Escherichia coli research studies
- Immunotherapy and Immune Responses
- Brucella: diagnosis, epidemiology, treatment
- Bacterial Infections and Vaccines
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
Griffith University
2008-2010
Abstract The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate Syk-Card9 signaling in APCs. In this study, we have further investigated the molecular mechanism of innate immune activation by TDM TDB. Syk-coupling adapter protein FcRγ was essential macrophage Th17 adjuvanticity. FcRγ-associated C-type lectin receptor Mincle expressed macrophages upregulated Recombinant...
Abstract The recognition of carbohydrate moieties by cells the innate immune system is emerging as an essential element in antifungal immunity, but despite number and diversity lectins expressed cells, few receptors have been characterized. Mincle, a C-type lectin, predominantly on macrophages, here shown to play role macrophage responses yeast Candida albicans. After exposure vitro, Mincle localized phagocytic cup, it was not for phagocytosis. In absence production TNF-α macrophages...
Candida albicans is a causative agent in mycoses of the skin, oral cavity, and gastrointestinal tract. Identification receptors, their respective ligands, that are engaged by immune cells when contact with C. crucial for understanding inflammatory responses leading to invasive candidiasis. Mincle recently identified macrophage-expressed receptor important host albicans. The carbohydrate-recognition domain human mouse were expressed, purified under denaturing conditions, successfully...