A5044701938- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Microbial Natural Products and Biosynthesis
- Moyamoya disease diagnosis and treatment
- Fungal Biology and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological Complications and Syndromes
- Signaling Pathways in Disease
- Cardiovascular Health and Disease Prevention
- Plant biochemistry and biosynthesis
- Mechanical Engineering and Vibrations Research
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Fungal and yeast genetics research
- Neurosurgical Procedures and Complications
- Advanced MRI Techniques and Applications
- Marine Sponges and Natural Products
- Soil Mechanics and Vehicle Dynamics
- Advanced Neuroimaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
Iwate Medical University
2012-2024
Jikei University School of Medicine
2021
University of Toyama
2018
Nagoya University
1993-2015
Iwate University
1999-2012
Kobe University
2011
Yamagata University
2010
Japanese Red Cross Nagoya Daini Hospital
1999
Gifu Prefectural Tajimi Hospital
1979
Tokyo Teishin Hospital
1956
Object. Gamma knife surgery (GKS) has been a safe and effective treatment for vestibular schwannomas in both the short long term, although less is known about long-term outcomes past 10 years. The aim of this study was to clarify patients with treated using GKS based on techniques place early 1990s. Methods. Eighty harboring schwannoma (excluding neurofibromatosis Type 2) were between May 1991 December 1993. Among these, 73 assessed; seven lost follow up. median duration up 135 months. mean...
Object. The goal of this study was to evaluate the neuroprotective effects conferred by long-term electrical stimulation subthalamic nucleus (STN) against degeneration dopaminergic neurons assessing motor functional and immunohistological findings in hemiparkinsonian rats. Methods. In 13 25 rats, a concentric microelectrode stereotactically implanted into right STN under guidance extracellular recording. After had been done animals were given an injection 6-hydroxydopamine (6-OHDA) striatum....
Object. Neurofibromatosis Type 2 (NF2) is an intractable disorder predisposing to multiple, recurrent tumors of the central nervous system (CNS). To clarify survival rate and characteristics that predict poor survival, we retrospectively reviewed clinical data in cases NF2. Methods. From among 283 patients with neurofibromatosis who had been registered a nationwide study Japan between 1986 1987, 74 bilateral vestibular schwannomas were analyzed. The mean duration follow up after diagnosis...
Adeno‐associated virus (AAV) has attracted considerable interest as a potential vector for gene therapy because of its wide host range, high transduction efficiency, and lack cytopathogenicity. In this experiment, we evaluated the efficacy AAV containing herpes simplex thymidine kinase ( HSV‐tk ) on human gliomas transplanted into brain nude mice. Complete regression tumors was observed after multiple AAV‐tk injections followed by intraperitoneal ganciclovir (GCV) administration, survival...
Deep brain stimulation (DBS) of subcortical nuclei such as the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNR) may provide an alternative therapy for intractable epilepsy. The authors attempted to evaluate antiepileptic effects DBS these structures in experimental seizure model.Three groups rats were prepared. In first two groups, underwent unilateral implantation electrodes STN (six rats) SNR rats). A control group received no Kainic acid (KA) was systemically...
Severe subarachnoid hemorrhage (SAH) induces dysfunction of endothelial nitric oxide synthase (eNOS), resulting in severe vasospasm. Clinically, however, some portions cerebral arteries may show only mild Although vasospastic after SAH have been intensively studied, activity eNOS associated with the form disease has received less attention. The purpose present study was to clarify molecular mechanisms underlying regulation SAH. In a rat single-hemorrhage model, basilar were obtained up 7...
The present study examined whether preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with development of cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients misery perfusion due ischemic moyamoya disease. Among 65 disease, 19 had in the precentral region on preoperative 15 O positron emission tomography and underwent that region. Brain technetium-99 m-labeled ethyl cysteinate dimer single-photon...
A new biological activity of falcarindiol isolated from Japanese parsley (Oenanthe javanica) using the mutant yeast YNS17 strain (zds1Δ erg3Δ pdr1Δ pdr3Δ) was discovered as an inhibitor glycogen synthase kinase-3β (GSK-3β). Falcarindiol inhibited GSK-3β in ATP noncompetitive manner with a Ki value 86.9 μM human enzyme and luminescent kinase assay platform. also both suppressed gene expression glucose-6-phosphatase (G6Pase) rat hepatoma H4IIE cells protected mouse neuroblastoma HT22...
Objective: The purpose of the present exploratory study was to evaluate effects uncomplicated carotid endarterectomy (CEA) on cognitive function and brain perfusion in patients with unilateral asymptomatic severe stenosis internal artery (ICA) by comparison unoperated patients.Methods: Patients age ≤75 years (≥70%) cervical ICA underwent CEA antiplatelet therapy (surgically treated group: 116 patients) or alone neither (medically 45 patients). For surgically group, neuropsychological testing...
Energy consumption and CO2 emission are world-wide problems. In Japan, a new project for reducing CO2, called "Energy ITS project" has started since 2008 by NEDO (New Industrial Technology Development Organization). this paper, path following control method based on nonholonomic tracking autonomous drivinng of automotives is proposed to follow the determined as accurately possible. Path can treat nonlinearities system, it reference more accurately. Different from control, separates velocity...
Monoclonal antibodies were produced by immunization of the human glioma cell line SK-MG-4. One antibodies, designated G-22, reacted with 18 20 lines, two melanoma and three lung cancer but not 39 lines derived from sarcoma, carcinoma, or hematopoietic tumors. The antigen was expressed in brain fetuses early gestation (9 weeks) late (8 months) normal adult brain, suggesting that antibody recognizes neural differentiation antigens neuroectodermal origin. A high incidence positive has been...
BackgroundCationic liposomes containing the human interferon β (HuIFNβ) gene (IAB-1) was used for clinical trial glioma patients. HuIFNβ therapy showed much higher anti-tumor activity compared with administration of protein melanoma. These results suggest that is an attractive strategy treatment
A new biological activity of 6-(methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor glycogen synthase kinase-3β. The most potent isothiocyanate, 9-(methylsulfinyl)hexyl inhibited kinase-3β at a K(i) value 10.5 µM and showed ATP competitive inhibition. structure-activity relationship revealed inhibitory potency methylsulfinyl dependent on the alkyl chain length sulfoxide, sulfone, and/or moiety.