A5100763423- Radiopharmaceutical Chemistry and Applications
- Radioactive element chemistry and processing
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Traditional Chinese Medicine Studies
- Crystallization and Solubility Studies
- Complementary and Alternative Medicine Studies
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Peptidase Inhibition and Analysis
- Acupuncture Treatment Research Studies
- Prostate Cancer Treatment and Research
- Acute Lymphoblastic Leukemia research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Plant Ecology and Soil Science
- Gynecological conditions and treatments
- Breast Cancer Treatment Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer, Lipids, and Metabolism
- Metal complexes synthesis and properties
- Environmental and Agricultural Sciences
- Boron Compounds in Chemistry
- Lipid metabolism and biosynthesis
- Blood Coagulation and Thrombosis Mechanisms
- Hematological disorders and diagnostics
University of British Columbia
2019-2022
TRIUMF
2019-2022
Imperial College London
2020
Vancouver Biotech (Canada)
2020
KalVista Pharmaceuticals (United States)
2019
St Mary's Hospital
2017
West Middlesex University Hospital
2016
Middlesex Hospital
2016
Lister Hospital
2014
Peterborough City Hospital
2013
Herein, we present the syntheses and characterization of a new undecadendate chelator, H4py4pa, its bifunctional analog H4py4pa-phenyl-NCS, conjugated to monoclonal antibody, Trastuzumab, which targets HER2+ cancer. H4py4pa possesses excellent affinity for 225Ac (α, t1/2 = 9.92 d) targeted alpha therapy (TAT), where quantitative radiolabeling yield was achieved at ambient temperature, pH 7, in 30 min 10–6 M chelator concentration, leading complex highly stable mouse serum least 9 d. To...
Here, we present the synthesis and characterization of a new potentially nonadentate chelator H4pypa its bifunctional analogue tBu4pypa-C7-NHS conjugated to prostate-specific membrane antigen (PSMA)-targeting peptidomimetic (Glu-urea-Lys). is very functionally versatile biologically stable. Compared conventional chelators (e.g., DOTA, DTPA), has outstanding affinities for both 111In (EC, t1/2 ≈ 2.8 days) 177Lu (β-,γ, 6.64 days). Its radiolabeled complexes were achieved at >98% radiochemical...
44Sc is an attractive positron-emitting radionuclide for PET imaging; herein, a new complex of the Sc3+ ion with nonmacrocyclic chelator H4pypa was synthesized and characterized high-resolution electrospray-ionization mass spectrometry (HR-ESI-MS), as well different nuclear magnetic resonance (NMR) spectroscopic techniques (1H, 13C, 1H–13C HSQC, HMBC, COSY, NOESY). In aqueous solution (pH = 7), [Sc(pypa)]− presented two isomeric forms, structures which were predicted using density functional...
One of the main challenges in targeted alpha therapy is assuring delivery α‐particle dose to cells. Thus, it critical identify ligands for α‐emitting radiometals that will form complexes are very stable, both vitro and vivo. In this investigation, thorium‐227 ( t 1/2 = 18.70 days) chelation containing hydroxypyridinonate (HOPO) or picolinic acid (pa) moieties stability resultant were studied. Chelation reactions followed by reversed‐phased HPLC gamma spectroscopy. Studies revealed high 227...
Hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality worldwide with limited therapeutic options for advanced disease. Targeted alpha therapy (TAT) an emerging class targeted cancer in which alpha-particle-emitting radionuclides, such as thorium-227, are specifically delivered to tissue. Glypican-3 (GPC3) cell surface glycoprotein highly expressed on HCC. In this study, we describe the development vivo efficacy <sup>227</sup>Th-labeled GPC3 targeting antibody...
H<sub>4</sub>pypa was conjugated to an antibody <italic>via</italic> a newly synthesized H<sub>4</sub>pypa-phenyl-NCS; promising immuno-PET imaging with 44Sc demonstrated.
Auger electron therapy exploits the cytotoxicity of low-energy electrons emitted during radioactive decay that travel very short distances (typically <1 μm). 201Tl, with a half-life 73 h, emits ∼37 and other secondary per can be tracked in vivo as its gamma emissions enable SPECT imaging. Despite useful nuclear properties satisfactory bifunctional chelators to incorporate it into bioconjugates for molecular targeting have not been developed. H4pypa, H5decapa, H4neunpa-NH2, H4noneunpa are...
H4pypa is a nonadentate nonmacrocyclic chelator, which previously demonstrated high affinity for scandium-44, lutetium-177, and indium-111. Herein, we report the highly stable binary [Zr(pypa)] complex; nonradioactive complex was synthesized characterized in detail using high-resolution electrospray-ionization mass spectroscopy (HR-ESI-MS) various nuclear magnetic resonance spectroscopies (NMR), revealed C2v symmetry of complex. The geometry further detailed via X-ray crystallography...
Severe acute respiratory syndrome coronavirus 2-infected pneumonia (novel coronavirus-infected [NCIP]) is a new viral illness initially identified in the central Chinese city of Wuhan December 2019. According to daily report on epidemic situation disease (COVID-19) issued by National Health and Family Planning Commission People's Republic China March 23, 2020: COVID-19 highly infectious, causing extremely high incidence NCIP throughout has spread swiftly 34 provinces within >100 other...
Infertility is the inability of a sexually active, non-contracepting couple to achieve pregnancy in one year.In recent years, more couples are looking alternative and complementary medicine (CAM) satisfactory result, although conventional treatment possesses many effective therapies treat infertility.Chinese Herbal Medicine (CHM) can be very treatment.Through combining multiple from within this traditional medical system, such as CHM acupuncture together, CHM, otherwise known TCM, enhance...
A new bifunctional <sup>t</sup>Bu<sub>4</sub>octapa-alkyl-NHS was synthesized for metalloradiopeptide preparation; proof-of-principle prostate-cancer targeting with lutetium-177 demonstrated.
Traditional Chinese medicine (TCM) has been widely used in China and other East Asian countries for helping cancer patients. However, it is unavailable to most patients who are treated NHS UK, due there not enough evidence using TCM patients, To try establish the base management, author reviewed current available clinical reports treatment of mainly those randomly assigned controlled trials (RCTs) with bigger samples, from maintaining quality life, enhancing immune system, remedying side...
Water resources are the most significant factor restricting basins development. The East Juyan Lake is terminal lake belongs to part of lower reaches in Heihe river basin arid western China.because water reduction, area oasis degraded rapidly, especially influence and many ecoenvironmental problems have emerged River baisn. For sake improving eco-environment, deterring trend further degradation lake, “water diversion” project was carried out 2000. In order objectively evaluate regulation on...