A5085969751- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Radioactive element chemistry and processing
- Lanthanide and Transition Metal Complexes
- Boron Compounds in Chemistry
- Seismic Imaging and Inversion Techniques
- Seismic Waves and Analysis
- Geotechnical and Geomechanical Engineering
- Chemical Reactions and Isotopes
- Tunneling and Rock Mechanics
- Synthesis and Biological Evaluation
- Rock Mechanics and Modeling
- Organometallic Complex Synthesis and Catalysis
- Geomechanics and Mining Engineering
- Hydrological Forecasting Using AI
- Geophysical and Geoelectrical Methods
- Trace Elements in Health
- Seismology and Earthquake Studies
- Landslides and related hazards
- Radiomics and Machine Learning in Medical Imaging
- Metal complexes synthesis and properties
- Flood Risk Assessment and Management
- Advanced MRI Techniques and Applications
Lawrence Berkeley National Laboratory
2024-2025
King's College London
2020-2024
St Thomas' Hospital
2020-2023
Bangor University
2023
Cardiff University
2017
Thorium-227 (
The reaction of phosphole/arsole starting materials with a series halide abstraction reagents afforded their respective phosphenium/arsenium complexes. UV–vis absorption and luminescence studies on these cations showed interesting emission profiles, which were found to be dependent upon counterion choice. addition reductant the phosphole reagent garnered dimeric species central P–P bond, when heated was undergo homolytic bond cleavage produce an 11π radical complex. Electron paramagnetic...
Thallium-201 is a radionuclide that has previously been used clinically for myocardial perfusion scintigraphy. Although in this role it now largely replaced by technetium-99 m radiopharmaceuticals, thallium-201 remains attractive the context of molecular therapy cancer micrometastases or single circulating tumour cells. This due to its Auger electron (AE) emissions, which are amongst highest total energy and number per decay AE-emitters. Currently, chemical platforms achieve potential...
Auger electron therapy exploits the cytotoxicity of low-energy electrons emitted during radioactive decay that travel very short distances (typically <1 μm). 201Tl, with a half-life 73 h, emits ∼37 and other secondary per can be tracked in vivo as its gamma emissions enable SPECT imaging. Despite useful nuclear properties satisfactory bifunctional chelators to incorporate it into bioconjugates for molecular targeting have not been developed. H4pypa, H5decapa, H4neunpa-NH2, H4noneunpa are...
The synthesis and characterisation of a series Kryptofix 222-based chelators that can be radiolabelled with 201 Tl( i ) in high radiochemical yields at ambient temperature are described.
This paper considers dynamic fracturing of the rockmass surrounding a tunnel statically loaded by compressional stress as possible source seismic events in underground mines. begins with two-dimensional modelling failure for six plausible scenarios. In each case, derived from these models has significant negative isotropic and compensated linear vector dipole components well P-axis approximately aligned direction maximum principal stress. These features indicate that at wavelengths larger...
Background: Multi-tracer PET/SPECT imaging enables different modality tracers to be present simultaneously, allowing multiple physiological processes imaged in the same subject, within a short time-frame. Fluorine-18 and technetium-99m, two commonly used PET SPECT radionuclides respectively, possess emission profiles, offering potential for one presence of other. However, impact each radionuclide on scanning other could significant lead confounding results. Here we use combinations 18F 99mTc...
Research involving multistakeholder collaborative partnerships is growing, as both academia and funding agencies align their objectives with societal challenges undertake research in the context of application. In particular, UN sustainable development goals mandate green process innovation that transcends disciplinary boundaries. Responding to this opportunity, article explores question: how can researchers, stakeholders, collaborate design implementation a initiative produce actionable...
KP46 (tris(hydroxyquinolinato)gallium(III)) is an experimental, orally administered anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly understood. We aimed gain insight into these issues using gallium-67 gallium-68 as radiotracers with SPECT PET imaging in mice. [
Abstract Background Hypoxia is central to many cardiac pathologies, but clinically its presence can only be inferred by indirect biomarkers including hypoperfusion and energetic compromise. Imaging hypoxia directly could offer new opportunities for the diagnosis sub-stratification of cardiovascular diseases. Objectives To determine whether [ 64 Cu]CuCTS Positron Emission Tomography (PET) identify in a murine model hypertrophy. Methods Male C57BL/6 mice underwent abdominal aortic constriction...
Abstract Compared to existing schemes, the decomposition of moment tensors for mining-induced seismic events into closing-crack and double-couple components has advantage that each can be interpreted in terms a physical source process (excavation convergence slip/shear, respectively). Obviously, not every tensor permits such decomposition, we translate bounds on those do Hudson source-type plot. For falling within these bounds, it previously been noted there will infinite set possible...
Increasingly, funded research projects are expected to address critical societal challenges. These challenges require generating and integrating multi-disciplinary practical knowledge through collaboration among different actors. Correspondingly, many funding agencies demand more insightful planning, reporting proof of performance, showing how what the has achieved against key performance indicators, as well impacts contributions, such UN Sustainable Development Goals.Such complex requires...
Chelators based on hydroxypyridinones have utility in incorporating radioactive metal ions into diagnostic and therapeutic agents used nuclear medicine. Over the course of our hydroxypyridinone studies, we prepared two novel chelators, consisting a cyclen (1,4,7,10-tetraazacyclododecane) ring bearing pendant groups, appended via methylene acetamide motifs at either 1,4-positions (L1) or 1,7-positions (L2) ring. In radiolabeling reactions L1 L2 with γ-emitting radioisotope, [111In]In3+,...