A5040588722- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Bone health and treatments
- X-ray Diffraction in Crystallography
- Medical Imaging and Pathology Studies
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- Retinoids in leukemia and cellular processes
- Biotin and Related Studies
- Nanoparticle-Based Drug Delivery
- Hormonal Regulation and Hypertension
- Alzheimer's disease research and treatments
- Galectins and Cancer Biology
- Organoselenium and organotellurium chemistry
- Computational Drug Discovery Methods
- Lysosomal Storage Disorders Research
- Vitamin K Research Studies
- Signaling Pathways in Disease
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Geological Formations and Processes Exploration
- Monoclonal and Polyclonal Antibodies Research
- Trypanosoma species research and implications
- Adrenal and Paraganglionic Tumors
- Eicosanoids and Hypertension Pharmacology
St Thomas' Hospital
2014-2023
King's College London
2014-2021
Transnational Press London
2018
St. Thomas Hospital
2014-2018
Dayanand Medical College & Hospital
2010
Vascular calcification is common among aging populations and mediated by vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) involved in protein folding ER stress has been implicated bone mineralization. role of VSMC-mediated less clear. Approach Results: mRNA expression the markers PERK (PKR (protein kinase RNA)-like kinase), ATF (activating transcription factor) 4, ATF6, Grp78 (glucose-regulated protein, 78 kDa) was detectable human vessels with levels decreased calcified...
Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization bone and vasculature has devastating effects on patient health, yet integrated understanding chemical cell biological processes that lead to mineral nucleation remains elusive. Here, we report biomineralization associated with poly(ADP-ribose) synthesized by polymerases in response oxidative and/or DNA damage. We use ultrastructural methods show can form both calcified spherical...
The ionophore 8-hydroxyquinoline (oxine) has been used to radiolabel cells and liposomal nanomedicines with the PET radiometal manganese-52.
The increased expression of 18 kDa Translocator protein (TSPO) is one the few available biomarkers neuroinflammation that can be assessed in humans vivo by positron emission tomography (PET). TSPO PET imaging central nervous system (CNS) has been widely undertaken, but to date no clear consensus reached about its utility brain disorders. One reason for this could because interpretation signal remains challenging, given cellular heterogeneity and ubiquity brain. aim current study was...
Labelling proteins with gallium-68 using bifunctional chelators is often problematic because of unsuitably harsh labelling conditions such as low pH or high temperature and may entail post-labelling purification. To determine whether tris(hydroxypyridinone) (THP) offer a potential solution to this problem, we have evaluated the biodistribution THP conjugate new single-chain antibody against prostate-specific membrane antigen (PSMA), an attractive target for staging prostate cancer (PCa). A...
Primary aldosteronism accounts for 6–15% of hypertension cases, the single biggest contributor to global morbidity and mortality. Whilst ~50% these patients have unilateral aldosterone-producing adenomas, only a minority curative surgery as current diagnosis disease is poor. Carbon-11 radiolabelled metomidate ([11C]MTO) positron emission tomography (PET) radiotracer able selectively identify CYP11B1/2 expressing adrenocortical lesions adrenal gland. However, use [11C]MTO limited PET centres...
The first (99m)Tc and (188)Re complexes containing two pendant bisphosphonate groups have been synthesised, based on the mononuclear M(v) nitride core with dithiocarbamate ligands each a bisphosphonate. structural identity of (99)Tc stable rhenium analogues as uncharged, nitridobis(dithiocarbamate) was determined by electrospray mass spectrometry. complex showed greater affinity for synthetic biological hydroxyapatite, stability in media, than well-known but poorly-characterised...
The water-soluble vitamin biotin is essential for cellular growth, development, and well-being, but its absorption, distribution, metabolism, excretion are poorly understood. This paper describes the radiolabeling of with positron emission tomography (PET) radionuclide carbon-11 ([11C]biotin) to enable quantitative study trafficking in vivo. We show that intravenously administered [11C]biotin quickly distributed liver, kidneys, retina, heart, brain rodents—consistent known expression...
We describe the case of a large intrathyroidal parathyroid adenoma in 46-year-old woman who had history recently diagnosed hypercalcaemia and 2-year an asymptomatic enlargement right lobe thyroid. This rare highlights potential difficulties that can arise evaluation hyperparathyroidism, especially cases multinodular goiter. In some cases, including this one, even thorough preoperative includes radiological studies (ultrasonography computed tomography [CT]) may not allow for definitive...
Niemann-Pick C disease (NPC) is an autosomal recessive lysosomal storage disorder resulting from mutations in the NPC1 (95% of cases) or NPC2 genes. Disturbance copper homeostasis has been reported disease. In this study we have used whole-body positron emission tomography (PET) and brain electronic autoradiography with copper-64 (64Cu), form copper(II) bis(thiosemicarbazonato) complex 64Cu-GTSM, to image short-term changes trafficking after intravenous injection a transgenic mouse model...
Ebselen, a potential new lithium-like drug, treatment reduced brain glutamate, as measured by PET imaging using the mGluR5 radioligand [18 F]FPEB in rats.
Background: Multi-tracer PET/SPECT imaging enables different modality tracers to be present simultaneously, allowing multiple physiological processes imaged in the same subject, within a short time-frame. Fluorine-18 and technetium-99m, two commonly used PET SPECT radionuclides respectively, possess emission profiles, offering potential for one presence of other. However, impact each radionuclide on scanning other could significant lead confounding results. Here we use combinations 18F 99mTc...
KP46 (tris(hydroxyquinolinato)gallium(III)) is an experimental, orally administered anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly understood. We aimed gain insight into these issues using gallium-67 gallium-68 as radiotracers with SPECT PET imaging in mice. [
Alzheimer's disease (AD) is associated with the presence of amyloid plaques in brain mainly comprised aggregated forms amyloid-β (Aβ). Molecules radiolabeled technetium-99m that cross blood–brain barrier (BBB) and selectively bind to Aβ have potential assist diagnosis AD using single-photon emission computed tomography imaging. In this work, three new tetradentate ligands pyridyl, amide, amine thiol donors, featuring a styrylpyridyl group known interact plaques, were prepared. The formed...
<h3>Introduction</h3> Vascular calcification is considered to be a significant predictor of coronary heart disease. It also associated with serious clinical complications such as left ventricular hypertrophy and calcific uremic arteriolopathy. Matrix vesicles apoptotic bodies (AB’s) released by calcifying vascular smooth muscle cells (VSMC’s) form the nidus for in vessel wall. Electron beam computed tomography (EBCT), gold standard non-invasive imaging quantitation fails provide any...