A5068018868- Radiopharmaceutical Chemistry and Applications
- Trace Elements in Health
- Medical Imaging Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Drug Transport and Resistance Mechanisms
- Environmental Justice and Health Disparities
- Animal testing and alternatives
- Electrochemical Analysis and Applications
- Pharmacological Effects and Toxicity Studies
- Pluripotent Stem Cells Research
- Arsenic contamination and mitigation
- Occupational and environmental lung diseases
- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
Joint Research Centre
2022-2023
St Thomas' Hospital
2018-2023
King's College London
2018-2022
Laboratoire d’Imagerie Biomédicale
2019
The use of cell and tissue-based methods in basic, applied regulatory science has been increasing exponentially. Animal-derived components, including serum, coating materials, growth factors antibodies are routinely used cell/tissue cultures general laboratory practices. In addition to ethical issues, the production animal-derived materials reagents raises many scientific concerns, generally associated with presence undefined components batch-to-batch variability, which may compromise...
Non-invasive imaging techniques to dynamically map whole-body trafficking of essential metals in vivo health and diseases are needed. Despite 62Zn having appropriate physical properties for positron emission tomography (PET) (half-life, 9.3 h; emission, 8.2%), its complex decay via 62Cu 10 min; 97%) has limited use. We aimed develop a method extract from 62Zn/62Cu generator, investigate use zinc despite decay. prepared by proton irradiation natural copper foil was used construct conventional...
KP46 (tris(hydroxyquinolinato)gallium(III)) is an experimental, orally administered anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly understood. We aimed gain insight into these issues using gallium-67 gallium-68 as radiotracers with SPECT PET imaging in mice. [
Abstract Copper imbalance is implicated in many diseases, including cancer. blood mainly transported by carrier proteins but a small fraction bound to low molecular weight species, possibly amino acids. Their roles cellular copper delivery are unknown. Our aim was test whether accumulation of 64Cu into cancer-derived cells can be influenced copper-binding serum In vitro measured Hank's Balanced Salt Solution the presence 100 μM l-histidine, l-methionine, l-cysteine and l-threonine....
Abstract Background Environmental risk factors, such as exposure to air pollution, are linked with lung cancer. However, potential health impacts of carcinogenic pollutants in soil less defined. In this ecological study, we evaluated at a regional scale associations between cancer mortality and the content two carcinogens: arsenic cadmium. Methods Data on deaths from were EUROSTAT. Soil cadmium Land use/cover area frame (LUCAS) 2009 survey. Analysis covered 26 EU countries 21,035 sampling...