A5021079916- Neuroscience and Neuropharmacology Research
- Memory Processes and Influences
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Child and Animal Learning Development
- Antenna Design and Optimization
- Pharmacological Receptor Mechanisms and Effects
- Tryptophan and brain disorders
- Creativity in Education and Neuroscience
- Prion Diseases and Protein Misfolding
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Neuroscience, Education and Cognitive Function
Universidad Autónoma de Madrid
2021-2024
Instituto Cajal
2021-2024
Universidad Politécnica de Madrid
2021-2024
King's College London
2019-2023
The increased expression of 18 kDa Translocator protein (TSPO) is one the few available biomarkers neuroinflammation that can be assessed in humans vivo by positron emission tomography (PET). TSPO PET imaging central nervous system (CNS) has been widely undertaken, but to date no clear consensus reached about its utility brain disorders. One reason for this could because interpretation signal remains challenging, given cellular heterogeneity and ubiquity brain. aim current study was...
Postmortem studies suggest that schizophrenia is associated with abnormal expression of specific GABA
As we navigate our day-to-day lives, regularly adapt behaviour according to what predict may happen next in a given context. When an unexpected event occurs, predictions about the world are disrupted and must be updated. Unexpected, isolated events, particularly with high emotionality, also better recalled. In present work, investigated how oddballs affect recall dynamics. Seventy young, healthy participants encoded word lists containing either emotional or perceptual at varying stimulus...
Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or secondary outcome. For that reason, either diagnostic tools to monitor progression and/or pharmacological interventions, there need for robust biomarkers neuroinflammation in the brain. Mitochondrial TSPO (18 kDa Translocator protein) one few available which are clinically PET imaging agents. In this study, we further characterised mouse model prion-induced chronic neurodegeneration...
Abstract Post-mortem studies suggest that schizophrenia is associated with abnormal expression of specific GABA A receptor (GABA R) α subunits, including α5GABA R. Positron emission tomography (PET) measures R availability in schizophrenia, however, have not revealed consistent alterations vivo . Animal using the agonist [ 3 H]-muscimol provide evidence antipsychotic drugs influence availability, a region-specific manner, suggesting potential confounding effect these drugs. No such data, are...
Declaring the 1990s as The Decade of Brain put field neuroscience at forefront public attention, with nervous system becoming a subject increasing interest in popular media. Although this has generally brought large swaths closer to neuroscience, most current research is published and disseminated single language: English. This unsurprising English indeed lingua franca scientific circles, but people around world communicate many other languages. To make accessible larger audience, we share...
Abstract Background Post-mortem studies in schizophrenia (SZ) have reported abnormalities the GABAergic system, more specifically, on αGABA-A receptors (αGABA-A R) (Benes, Kwok, Vincent, & Todtenkopf, 1998; Beneyto, Abbott, Hashimoto, Lewis, 2011). Consistently, animal models of SZ also changes these receptor subtypes (Lodge, Behrens, Grace, 2009; Richetto, Calabrese, Riva, Meyer, 2014). Preclinical work methylazoxymethanol acetate (MAM) model has shown that administration an α5GABA-A...
As we navigate our day to lives, regularly adapt behaviour according what predict may happen next in a given context. When an unexpected event occurs predictions about the world are disrupted and must be updated. Unexpected, isolated events, particularly with high emotionality, also better recalled. In present work, investigated how oddballs affect recall dynamics. Seventy young, healthy participants encoded word lists containing either emotional or perceptual at varying stimulus onset...