A5087487564- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Eating Disorders and Behaviors
- Hormonal Regulation and Hypertension
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Reproductive Biology and Fertility
- Cardiac Health and Mental Health
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Adolescent and Pediatric Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Health, psychology, and well-being
- Child and Adolescent Psychosocial and Emotional Development
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Birth, Development, and Health
- Dietary Effects on Health
- Preterm Birth and Chorioamnionitis
- Prion Diseases and Protein Misfolding
- Early Childhood Education and Development
- Advanced Neuroimaging Techniques and Applications
- Intergenerational Family Dynamics and Caregiving
- Parallel Computing and Optimization Techniques
King's College London
2017-2024
King's College - North Carolina
2024
South London and Maudsley NHS Foundation Trust
2021-2023
The King's College
2022
London Women's Clinic
2021-2022
National Institute for Health Research
2021
Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes with disease, experimental data demonstrated proliferation as a component of the neuropathology. In this study, we tested efficacy selective CSF1R inhibitor JNJ-40346527 (JNJ-527) P301S mouse tauopathy model. We first anti-proliferative effects JNJ-527 on microglia ME7 prion model, its impact inflammatory...
This study aimed to investigate the role of baseline levels peripheral inflammation when testing efficacy antidepressant augmentation with minocycline in patients treatment-resistant depression. We conducted a 4-week, placebo-controlled, randomised clinical trial (200 mg/day) added treatment 39 selected for elevated serum C-reactive protein (CRP ≥ 1 mg/L), n = 18 (M) and 21 placebo (P). The main outcome was change Hamilton Depression Rating Scale (HAM-D-17) score from week 4, expressed both...
Childhood trauma is among the most potent contributing risk factors for depression and associated with poor treatment response. Hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been linked to both childhood depression, but underlying mechanisms are poorly understood. The present study aimed investigate link between trauma, HPA activity antidepressant response in patients depression. As part of Wellcome Trust NIMA consortium, 163 depressed 55 healthy volunteers were included this...
Abstract The mRNA expression signatures associated with the ‘pro-inflammatory’ phenotype of depression, and differential depression subtypes effects antidepressants, are still unknown. We examined 130 depressed patients (58 treatment-resistant, 36 antidepressant-responsive currently untreated) 40 healthy controls from BIODEP study, used whole-blood qPCR to measure 16 candidate mRNAs, some never measured before: interleukin ( IL)-1-beta , IL-6 TNF-alpha macrophage inhibiting factor MIF ),...
Abstract Arterial spin labeling (ASL) provides absolute quantification of resting tissue cerebral blood flow (CBF) as an entirely noninvasive approach with good reproducibility. As a result neurovascular coupling, ASL useful marker neuronal activity. Recent studies in individuals at clinical high risk psychosis (CHR) have reported increased hippocampal perfusion compared healthy controls. Schizotypy refers to the presence subclinical psychotic‐like experiences and represents robust framework...
Abstract Background Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent which depressive symptoms status contributed increased inflammation cortisol levels. Methods Participants were recruited through Wellcome Trust NIMA Consortium. The sample of 216 participants consisted 69 patients depression; 35 controls; 55 normal-weight depression 57 controls. Peripheral was measured as high-sensitivity C-Reactive Protein (hsCRP) in...
Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)-targeted positron emission tomography (PET) has used to assess neuroinflammation major depressive disorder. We aimed 1) test hypothesis significant case-control differences TSPO binding anterior cingulate cortex, prefrontal and insula regions; 2) explore relationship between cerebral peripheral blood C-reactive (CRP) concentration.A total 51 depressed subjects with Hamilton Depression Rating...
Abstract Animal models and human neuroimaging studies suggest that altered levels of glutamatergic metabolites within a corticolimbic circuit have major role in the pathophysiology schizophrenia. Rodent propose prefrontal glutamate dysfunction could lead to amygdala hyper-response environmental stress underlie hippocampal overdrive Here we determine whether changes brain are present individuals with high schizotypy (HS), which refers presence schizophrenia-like characteristics healthy...
Background Cortical glutamatergic dysfunction is thought to be fundamental for psychosis development, and may lead structural degeneration through excitotoxicity. Glutamate levels have been related gray matter volume (GMV) alterations in people at ultra-high risk of psychosis, we previously reported GMV changes individuals with high schizotypy (HS), which refers the expression schizophrenia-like characteristics healthy people. This study sought examine whether HS subjects are glutamate...
Abstract Background Research implicates inflammation in the vicious cycle between depression and obesity, yet few longitudinal studies exist. The rapid weight loss induced by bariatric surgery is known to improve depressive symptoms dramatically, but preoperative diagnosis may also increase risk for poor loss. Therefore, we investigated associations inflammatory markers their effect on clinical outcomes patients. Methods This observational study of 85 patients with obesity undergoing...
Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or secondary outcome. For that reason, either diagnostic tools to monitor progression and/or pharmacological interventions, there need for robust biomarkers neuroinflammation in the brain. Mitochondrial TSPO (18 kDa Translocator protein) one few available which are clinically PET imaging agents. In this study, we further characterised mouse model prion-induced chronic neurodegeneration...
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed investigate differences cortisol levels individuals with obesity without of perceived stress on these differences. Saliva samples were collected at awakening, 15-, 30- 60-minutes post-awakening from 66 (30 major depressive disorder 36 disorder). Salivary was analysed using ELISA technique. Linear Mixed Models used for group awakening...
Key content Fertility treatment using donated gametes and embryos is increasingly common. Indications for the use of sperm oocytes include azoospermia, single women in same‐sex relationships, inherited conditions, poor quality or failed fertilisation previous cycles assisted reproductive technology, ovarian insufficiency. Causes azoospermia insufficiency congenital genetic disorders, infectious traumatic iatrogenic causes age‐related decline. These have ethical legal implications require...
Background: Empirical evidence shows that healthy individuals with high schizotypy (HS), who show schizophrenia-like characteristics, present similar but attenuated social and emotional disturbances to patients schizophrenia. Altered glutamatergic neurotransmission in several limbic areas including the anterior cingulate cortex (ACC) has been demonstrated schizophrenia at ultra-high risk for psychosis is associated abnormalities brain activation during cognitive tasks. However, despite...