A5013772238- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Immune cells in cancer
- Reproductive System and Pregnancy
- Alzheimer's disease research and treatments
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 Impact on Reproduction
- Sleep and related disorders
- Prion Diseases and Protein Misfolding
- Olfactory and Sensory Function Studies
- Asthma and respiratory diseases
- Retinoids in leukemia and cellular processes
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Chemokine receptors and signaling
University of Glasgow
2014-2021
Institute of Infection and Immunity
2017
Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes with disease, experimental data demonstrated proliferation as a component of the neuropathology. In this study, we tested efficacy selective CSF1R inhibitor JNJ-40346527 (JNJ-527) P301S mouse tauopathy model. We first anti-proliferative effects JNJ-527 on microglia ME7 prion model, its impact inflammatory...
Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between immune and CNS does occur. As a result, patients with chronic inflammatory diseases, such as rheumatoid arthritis, bowel disease or psoriasis, are often further burdened neuropsychiatric symptoms, depression, anxiety fatigue. Despite advances our understanding of neuroimmune communication pathways, precise effect...
Abstract Background Recent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding neuroimmune communication pathways, how the brain senses and responds peripheral inflammation remains poorly understood. A better these pathways may be important for generating novel therapeutics treat many patients with chronic inflammatory diseases who also suffer from neuropsychiatric comorbidities. Here we systematically assessed...
Topical application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely used mouse model for investigating pathogenesis psoriasis. We have previously this to study effects peripheral inflammation on brain, and reported brain-specific response characterised by increased transcription, infiltration immune cells anhedonic-like behavior. Here, we perform more robust characterisation systemic find potent but transient in periphery, followed prolonged brain. Mass...
The relationship between the brain and immune system has become increasingly topical as, although it is immune-specialised, CNS not free from influences of system. Recent data indicate that peripheral stimulation can significantly affect CNS. But mechanisms underpinning this remain unclear. standard approach to understanding relied on systemic activation using bacterial components, finding mediators, such as cytokines, have a significant effect function behaviour. More rarely studies used...
Important insight into the mechanisms through which gene-environmental interactions cause schizophrenia can be achieved preclinical studies combining prenatal immune stimuli with disease-related genetic risk modifications. Accumulating evidence associates JNK signalling molecules, including MKK7/MAP2K7, risk. We tested hypothesis that Map2k7 gene haploinsufficiency in mice would alter response to viral mimetic polyriboinosinic-polyribocytidylic acid (polyI:C), specifically investigating...
The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance this heterogeneous condition. Peripheral blood measures cytokines and chemokines constitute bulk evidence, with consistent meta-analytic implicating raised proinflammatory such as IL6, IL1β TNF. Among potential linking changes to affective neurobiology is accelerated biological ageing seen MDD, particularly via senescence...
Abstract Exposure to infection in utero predisposes towards psychiatric diseases such as autism, depression and schizophrenia later life. The mechanisms involved are typically studied by administering mimetics of double-stranded (ds) virus or bacterial pregnant rats mice. effect single-stranded (ss) has been largely ignored, despite evidence linking prenatal ss exposure with disease. Understanding the effects gestational become even more important recent events. In this study, mice, we...
Microglial activation is believed to play a role in many psychiatric and neurodegenerative diseases. Based largely on evidence from other cell types, it widely thought that MAP kinase (ERK, JNK p38) signalling pathways contribute strongly microglial following immune stimuli acting toll-like receptor (TLR) 3 or TLR4. We report here exposure of SimA9 mouse line mimetics stimulating TLR4 (lipopolysaccharide-LPS) TLR7/8 (resiquimod/R848), results marked activation, followed by induction nitric...
TPA treatment causes psoriasis-like skin inflammation but does not induce a transcriptional response in the brain. Mice were treated with 100 μg of or an equal volume acetone every 24 h for 1, 3 5 consecutive days. (A) Mouse weights recorded after each treatment. euthanised final application and (B) areas sectioned to 5 μm, stained H&E visualised at ×100 magnification using light microscope. Epidermis [1], dermis [2], muscle [3] epidermal hyperplasia [4] are shown. Scale bar = 100 μm. (C)...
Abstract Background The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation variance this heterogeneous condition. Peripheral blood measures cytokines and chemokines constitute bulk evidence with consistent meta-analytic implicating raised proinflammatory such as IL6, IL1β TNF. Among potential linking changes to affective neurobiology is accelerated biological ageing seen MDD, particularly...
Abstract Exposure to infection in utero predisposes towards psychiatric diseases such as autism, depression and schizophrenia later life. The mechanisms involved are typically studied by administering mimetics of double-stranded (ds) RNA viral or bacterial pregnant rats mice. effect single-stranded (ss) virus has been largely ignored, despite evidence linking prenatal ss exposure specifically with disease. Understanding the effects gestational become even more important current SARS-CoV-2...