A5043602264- Salivary Gland Disorders and Functions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Urticaria and Related Conditions
- Immune cells in cancer
- Retinal Development and Disorders
- Celiac Disease Research and Management
- Pancreatic function and diabetes
- Renal Diseases and Glomerulopathies
- Retinal Diseases and Treatments
- Escherichia coli research studies
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Autophagy in Disease and Therapy
- Chemokine receptors and signaling
- Vasculitis and related conditions
- Gastrointestinal disorders and treatments
- Lymphoma Diagnosis and Treatment
University of Birmingham
2018-2023
University of Lübeck
2014-2021
Southampton General Hospital
2019-2020
University of Southampton
2017-2020
Queen Elizabeth Hospital Birmingham
2018
Centre for Inflammation Research
2018
Age UK
2018
Evangelismos Hospital
2009-2017
Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes with disease, experimental data demonstrated proliferation as a component of the neuropathology. In this study, we tested efficacy selective CSF1R inhibitor JNJ-40346527 (JNJ-527) P301S mouse tauopathy model. We first anti-proliferative effects JNJ-527 on microglia ME7 prion model, its impact inflammatory...
Abstract Although reports documented aberrant cytokine expression in autoimmune bullous dermatoses (AIBDs), cytokine-targeting therapies have not been established these disorders. We showed previously that IL-6 treatment protected against tissue destruction experimental epidermolysis bullosa acquisita (EBA), an AIBD caused by autoantibodies to type VII collagen (COL7). The anti-inflammatory effects of were mediated induction IL-1ra, and prophylactic IL-1ra administration prevented...
Background The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation, apoptosis and migration has been successfully targeted in B-cell malignancies. Primary Sjögren’s syndrome (pSS) is a chronic immune-mediated inflammatory disease characterised by exocrine gland lymphocytic infiltration hyperactivation which results systemic manifestations, autoantibody production loss of glandular...
Regulatory T cells (Tregs) are well known for their modulatory functions in adaptive immunity. Through regulation of cell functions, Tregs have also been demonstrated to indirectly curb myeloid cell-driven inflammation. However, direct effects on insufficiently characterized, especially the context cell-mediated diseases, such as pemphigoid diseases (PDs). PDs caused by autoantibodies targeting structural proteins skin. Autoantibody binding triggers activation through specific Fc gamma...
SS is an autoimmune condition characterized by systemic B-cell activation, autoantibody production and ectopic germinal centres' formation within the salivary gland (SG). The extent of SG infiltrate has been proposed as a biomarker disease severity. Plasma levels CXCL13 correlate with activity in animal models severity SS, suggesting its potential use surrogate serum marker to monitor local activation. aim this study was evaluate role pathology two independent cohorts.109 patients were...
Objective . To retrospectively evaluate ANCA testing in a cohort of unselected Greek in- and outpatients. Methods In 10803 consecutive serum samples, were tested by indirect immunofluorescence (IIF) ELISA. ELISA inpatients was performed only on IIF positive sera. Results Low prevalence (6.0%) samples observed. Among these 63.5% presented perinuclear (p-ANCA), 9.3% cytoplasmic (c-ANCA) 27.2% atypical (x-ANCA) pattern. 16.1% p-ANCA antimyeloperoxidase (anti-MPO) positive, whereas 68.3% c-ANCA...
The proliferation and activation of microglia, the resident macrophages in brain, is a hallmark many neurodegenerative diseases such as Alzheimer's disease (AD) prion disease. Colony stimulating factor 1 receptor (CSF1R) critically involved regulating microglial proliferation, CSF1R blocking strategies have been recently used to modulate microglia diseases. However, broadly expressed by cell types impact its inhibition on innate immune system still unclear. can be activated two independent...
Abstract Early stages of geographic atrophy (GA) age-related macular degeneration is characterised by the demise photoreceptors, which precedes loss underlying retinal pigment epithelial (RPE) cells. Sight-loss due to GA has no effective treatment; reflecting both complexity disease and lack suitable animal models for testing potential therapies. We report development characterisation a laser-induced mouse model with early GA-like pathology. Retinas were lasered at adjacent sites using 810...
Abstract Backgrounds The organization of minor salivary glands (MSG) infiltrates, in patients with Sjögren’s syndrome (SS), associates disease severity and progression. Aberrant regulation lymphocyte autophagy is involved autoimmunity, previous work, we provided the first evidence upregulated CD4+ T cells infiltrating SS MSG. aim this study was to further explore circulating lymphocytes investigate its role histopathological Methods After collection 20 MSG, presence aggregates (foci)...
Germinal centers (GCs) are sites where plasma and memory B cells form to generate high-affinity, Ig class-switched antibodies. Specialized stromal called follicular dendritic (FDCs) essential for GC formation. During systemic Salmonella Typhimurium (STm) infection GCs absent, whereas extensive extrafollicular switched antibody responses maintained. The mechanisms that underpin the absence of formation incompletely understood. Here, we demonstrate STm induces a reversible disruption niches...
The increasing prevalence of celiac disease (CD), especially in adults, its atypical clinical presentation, and the strict, lifelong adherence to gluten-free diet (GFD) as only option for healthy state create an imperative need noninvasive methods that can effectively diagnose CD monitor GFD. Aim . Evaluation anti-endomysium (EmA) anti-tissue transglutaminase IgA (tTG-A) antibodies diagnosis, GFD monitoring, first degree relatives screening adult patients. Methods 70 newly diagnosed Greek...
Abstract The proliferation and activation of microglia, the resident macrophages in brain, is a hallmark many neurodegenerative diseases such as Alzheimer’s disease (AD) prion disease. Colony stimulating factor 1 receptor (CSF1R) critically involved regulating microglial proliferation, CSF1R blocking strategies have been recently used to modulate microglia diseases. However, broadly expressed by cellular types impact its inhibition on innate immune system still unclear. can be activated two...
The antinuclear antibody (ANA) testing is an indispensable diagnostic tool for the management of systemic autoimmune rheumatic diseases (SARD).From initial discovery ANA identification until today there has been considerable technical progress in and standardisation which allow development commercial assay kits that are widespread used clinical research practice.In this mini-review we explore history recent advancements provide guidelines to laboratory interpretation assessment results.
<h3>Background:</h3> Autophagy is a lysosome mediated catabolic process that promotes cell survival during stress conditions. Aberrant regulation of autophagy involved in the pathogenesis widening spectrum autoimmune disorders: particular, activation pathway implicated aberrant activated T cells. We recently demonstrated up-regulated CD4+ lymphocytes from patients with Sjogren's Syndrome (SS) both peripheral blood and tissue. Moreover, correlates systemic disease activity. Little known on...
<h3>Background:</h3> The development of the B cell repertoire is regulated by process affinity maturation occurring within inner part follicles [germinal centers (GCs)] secondary lymphoid organs (SLOs). In autoimmunity, this might occur aberrant aggregates lymphocytes in target organs, such as ectopic structures (ELS) found salivary glands patients with Sjogren's Syndrome (SS) (1). phonotypical and functional features supporting ELS which may sustain autoimmune diseases have not been...
<h3>Background</h3> Ectopic production of the lymphoid chemokines CXCL13 and CXCL12 has been described in tertiary structures (TLS) that harbour salivary glands patients with Sjogren's Syndrome (pSS). Whilst expression correlates clinical features, its potential role as a biomarker to monitor organisation severity gland infiltrate hampered by lack sensitive tools describe TLS extent features. <h3>Objectives</h3> To investigate serum tissue find any possible association clinical, histological...
<h3>Career situation of first and presenting author</h3> Post-doctoral fellow. <h3>Introduction</h3> The development the B cell repertoire is regulated by process affinity maturation that occurs within inner part follicles secondary lymphoid organs (SLOs). In autoimmunity might occur in ectopic structures (ELS), aggregates lymphocytes form target disease (i.e. salivary glands patients with Sjogren's Syndrome (SS)). phenotypical functional features supporting ELS pathogenic properties have...