Melisa Kose
A5055895407- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Eating Disorders and Behaviors
- Hormonal Regulation and Hypertension
- Cardiac Health and Mental Health
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Vitamin D Research Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Mental Health Research Topics
- Delphi Technique in Research
- Prion Diseases and Protein Misfolding
- Neuroinflammation and Neurodegeneration Mechanisms
- Sex and Gender in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Scientific Computing and Data Management
- Retinal Diseases and Treatments
- Ethics in Clinical Research
- Parallel Computing and Optimization Techniques
- Electronic Health Records Systems
- Treatment of Major Depression
- Biomedical Text Mining and Ontologies
- Health, psychology, and well-being
- Advanced Memory and Neural Computing
- Cytokine Signaling Pathways and Interactions
King's College London
2020-2024
King's College - North Carolina
2024
The King's College
2022
Bahçeşehir University
2013
This study aimed to investigate the role of baseline levels peripheral inflammation when testing efficacy antidepressant augmentation with minocycline in patients treatment-resistant depression. We conducted a 4-week, placebo-controlled, randomised clinical trial (200 mg/day) added treatment 39 selected for elevated serum C-reactive protein (CRP ≥ 1 mg/L), n = 18 (M) and 21 placebo (P). The main outcome was change Hamilton Depression Rating Scale (HAM-D-17) score from week 4, expressed both...
Abstract The mRNA expression signatures associated with the ‘pro-inflammatory’ phenotype of depression, and differential depression subtypes effects antidepressants, are still unknown. We examined 130 depressed patients (58 treatment-resistant, 36 antidepressant-responsive currently untreated) 40 healthy controls from BIODEP study, used whole-blood qPCR to measure 16 candidate mRNAs, some never measured before: interleukin ( IL)-1-beta , IL-6 TNF-alpha macrophage inhibiting factor MIF ),...
Abstract Compelling evidence demonstrates that some individuals suffering from major depressive disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation-related proteins, such as serum or plasma C-reactive protein (CRP). However, the immune-related modifications associated with MDD may be not entirely captured by CRP alone. Analysing mRNA gene expression levels, we aimed to identify broader molecular phenotypes MDD. We examined 168 non-interventional,...
Sex hormones have biological effects on inflammation, and these might contribute to the sex-specific features of depression. C-reactive protein (CRP) is most widely used inflammatory biomarker consistent evidence shows a significant proportion (20–30 %) patients with major depressive disorder (MDD) CRP levels above 3 mg/L, threshold indicating at least low-grade inflammation. Here, we investigate interplay between sex in cross-sectional, observational Biomarkers Depression Study. We measured...
Abstract Transcriptomic profiles are important indicators for molecular mechanisms and pathways involved in major depressive disorder (MDD) its different phenotypes, such as immunometabolic depression. We performed whole-transcriptome pathway analyses on 139 individuals from the observational, case-control, BIOmarkers DEPression (BIODEP) study, 105 with MDD 34 controls. divided participants based levels of inflammation, measured by serum high-sensitivity C-reactive protein (CRP), n = 39 ‘not...
Abstract Background Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent which depressive symptoms status contributed increased inflammation cortisol levels. Methods Participants were recruited through Wellcome Trust NIMA Consortium. The sample of 216 participants consisted 69 patients depression; 35 controls; 55 normal-weight depression 57 controls. Peripheral was measured as high-sensitivity C-Reactive Protein (hsCRP) in...
Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)-targeted positron emission tomography (PET) has used to assess neuroinflammation major depressive disorder. We aimed 1) test hypothesis significant case-control differences TSPO binding anterior cingulate cortex, prefrontal and insula regions; 2) explore relationship between cerebral peripheral blood C-reactive (CRP) concentration.A total 51 depressed subjects with Hamilton Depression Rating...
Electronic Health Record (EHR) systems are digital platforms in clinical practice used to collect patients' information related their health status and represents a useful storage of real-world data. EHRs have potential role research studies, particular, platform trials. Platform trials innovative trial designs including multiple arms (conducted simultaneously and/or sequentially) on different treatments under single master protocol. However, the use comes with important challenges such as...
Abstract Background Research implicates inflammation in the vicious cycle between depression and obesity, yet few longitudinal studies exist. The rapid weight loss induced by bariatric surgery is known to improve depressive symptoms dramatically, but preoperative diagnosis may also increase risk for poor loss. Therefore, we investigated associations inflammatory markers their effect on clinical outcomes patients. Methods This observational study of 85 patients with obesity undergoing...
Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or secondary outcome. For that reason, either diagnostic tools to monitor progression and/or pharmacological interventions, there need for robust biomarkers neuroinflammation in the brain. Mitochondrial TSPO (18 kDa Translocator protein) one few available which are clinically PET imaging agents. In this study, we further characterised mouse model prion-induced chronic neurodegeneration...
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed investigate differences cortisol levels individuals with obesity without of perceived stress on these differences. Saliva samples were collected at awakening, 15-, 30- 60-minutes post-awakening from 66 (30 major depressive disorder 36 disorder). Salivary was analysed using ELISA technique. Linear Mixed Models used for group awakening...