A5030142772- Eating Disorders and Behaviors
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Obesity and Health Practices
- Regulation of Appetite and Obesity
- Obsessive-Compulsive Spectrum Disorders
- Sleep and Wakefulness Research
- Cardiac Health and Mental Health
- Obesity, Physical Activity, Diet
- Bariatric Surgery and Outcomes
- Hormonal Regulation and Hypertension
King's College London
2019-2023
South London and Maudsley NHS Foundation Trust
2023
Institute of Psychiatry and Neurology
2021
University College London
2019
Anorexia nervosa is characterized by anxiety-driven behaviors, such as food avoidance and distressing persistent thoughts about weight gain body image. The present study used a classical fear conditioning procedure to test the processes of acquisition generalization, extinction, renewal in patients with anorexia healthy controls. An app-based was administered remotely 64 60 controls, over two sessions. A human female scream served unconditioned stimulus (US) neutral shapes were either paired...
Abstract Background Research implicates inflammation in the vicious cycle between depression and obesity, yet few longitudinal studies exist. The rapid weight loss induced by bariatric surgery is known to improve depressive symptoms dramatically, but preoperative diagnosis may also increase risk for poor loss. Therefore, we investigated associations inflammatory markers their effect on clinical outcomes patients. Methods This observational study of 85 patients with obesity undergoing...
In recent years, the food addiction hypothesis of loss-of-control eating has gained traction in field disorders. particular, neural process plays a dominant role recently formulated "addictive appetite" model bulimia nervosa and binge disorder. Nonetheless, several components hypothesis, including presence withdrawal tolerance effects, as well proposition that some foods possess "addicting" properties, remain highly controversial. response, current review synthesises existing evidence for...
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been suggested to play a role in the association between depression and obesity. The study aimed investigate differences cortisol levels individuals with obesity without of perceived stress on these differences. Saliva samples were collected at awakening, 15-, 30- 60-minutes post-awakening from 66 (30 major depressive disorder 36 disorder). Salivary was analysed using ELISA technique. Linear Mixed Models used for group awakening...
Abstract Background There is extensive evidence for volumetric reductions in the hippocampus patients with anorexia nervosa (AN), however impact on function unclear. Pattern separation and recognition are hippocampus-dependent forms of learning thought to underlie stimulus discrimination. Methods The present study used Mnemonic Similarity Task investigate pattern first time AN ( N = 46) healthy controls 56). An Analysis Covariance examined between-group differences, controlling age,...