A5045129933- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Health, psychology, and well-being
- Mental Health Research Topics
- Hormonal Regulation and Hypertension
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Neurological Disease Mechanisms and Treatments
- Retinal Diseases and Treatments
- Multiple Sclerosis Research Studies
- Birth, Development, and Health
- Vitamin D Research Studies
- Functional Brain Connectivity Studies
- Leprosy Research and Treatment
- Crystal Structures and Properties
- Machine Learning in Bioinformatics
- Ocular Infections and Treatments
- Prion Diseases and Protein Misfolding
- Schizophrenia research and treatment
King's College London
2019-2023
Karolinska Institutet
2011-2023
The King's College
2022
King's College Hospital
2022
Stazione Sperimentale del Vetro
2020
Karolinska University Hospital
2016
Carol Davila University of Medicine and Pharmacy
2014
Spitalul Clinic de Psihiatrie Alexandru Obregia
2013
Alzheimer’s Disease Neuroimaging Initiative
2012
Spitalul Clinic Judetean de Urgentã Craiova
1979
Purpose of review Depression in people with dementia has important implications, such as reduced quality life patients and carers, is associated increased costs cognition. Here, we recent studies the epidemiology, course, mechanisms treatment depression dementia. Recent findings both a risk factor prodrome Alzheimer's disease. common occurrence all types dementias at disease stages, including mild cognitive impairment (MCI). Many have explored whether MCI conversion rate to dementia, but are...
This study aimed to investigate the role of baseline levels peripheral inflammation when testing efficacy antidepressant augmentation with minocycline in patients treatment-resistant depression. We conducted a 4-week, placebo-controlled, randomised clinical trial (200 mg/day) added treatment 39 selected for elevated serum C-reactive protein (CRP ≥ 1 mg/L), n = 18 (M) and 21 placebo (P). The main outcome was change Hamilton Depression Rating Scale (HAM-D-17) score from week 4, expressed both...
Childhood trauma is among the most potent contributing risk factors for depression and associated with poor treatment response. Hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been linked to both childhood depression, but underlying mechanisms are poorly understood. The present study aimed investigate link between trauma, HPA activity antidepressant response in patients depression. As part of Wellcome Trust NIMA consortium, 163 depressed 55 healthy volunteers were included this...
Abstract The mRNA expression signatures associated with the ‘pro-inflammatory’ phenotype of depression, and differential depression subtypes effects antidepressants, are still unknown. We examined 130 depressed patients (58 treatment-resistant, 36 antidepressant-responsive currently untreated) 40 healthy controls from BIODEP study, used whole-blood qPCR to measure 16 candidate mRNAs, some never measured before: interleukin ( IL)-1-beta , IL-6 TNF-alpha macrophage inhibiting factor MIF ),...
Abstract Compelling evidence demonstrates that some individuals suffering from major depressive disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation-related proteins, such as serum or plasma C-reactive protein (CRP). However, the immune-related modifications associated with MDD may be not entirely captured by CRP alone. Analysing mRNA gene expression levels, we aimed to identify broader molecular phenotypes MDD. We examined 168 non-interventional,...
Peripheral immune markers have previously been linked to a poor response antipsychotic medication and more severe negative symptoms at the onset of psychosis. The present study investigated association blood cytokines complement with presence non-response symptom severity in patients psychosis.This cross-sectional recruited 94 schizophrenia other psychoses, whom 47 were defined as responders non-responders. In all subjects we measured plasma levels (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10,...
Abstract Depression is associated with peripheral inflammation, but its link brain microglial activity remains unclear. In seven healthy males, we used repeated translocator protein-Positron Emission Tomography (TSPO-PET) dynamic scans [ 11 C]PBR28 to image activation before and 24 h after the immune challenge interferon (IFN)-α. We also investigated association between changes in activity, mood. IFN-α administration decreased PET tissue volume of distribution (Vt) across (−20 ± 4%; t 6 =...
<i>Background:</i> The aim of this study was to explore the relationship between cerebrospinal fluid Alzheimer’s disease (AD) markers and depression in elderly people. <i>Method:</i> We included subjects with AD as well persons subjective cognitive impairment normal cognition. Depression assessed Cornell Scale for Dementia, a cut-off score >6 used define depression. Cerebrospinal analyzed using commercially available assays β-amyloid 1–42, total tau, phosphorylated...
Background The association between mortality risk and use of antidepressants in people with dementia is unknown. Objective To describe the different diagnoses to explore associated 3 years before a diagnosis. Methods Study population included 20 050 memory clinic patients from Swedish Dementia Registry (SveDem) diagnosed incident dementia. Data on dispensed at time diagnosis during 3‐year period were obtained Prescribed Drug Register. Cox regression models used. Results During median...
Abstract Background Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent which depressive symptoms status contributed increased inflammation cortisol levels. Methods Participants were recruited through Wellcome Trust NIMA Consortium. The sample of 216 participants consisted 69 patients depression; 35 controls; 55 normal-weight depression 57 controls. Peripheral was measured as high-sensitivity C-Reactive Protein (hsCRP) in...
Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)-targeted positron emission tomography (PET) has used to assess neuroinflammation major depressive disorder. We aimed 1) test hypothesis significant case-control differences TSPO binding anterior cingulate cortex, prefrontal and insula regions; 2) explore relationship between cerebral peripheral blood C-reactive (CRP) concentration.A total 51 depressed subjects with Hamilton Depression Rating...
Objective: To determine whether depressive symptoms are associated with medial temporal lobe atrophy in older people and without Alzheimer disease (AD). Method: A total of 368 memory clinic patients AD, mild cognitive impairment, subjective impairment (SCI) were included. Depressive defined as a score 8 or higher on Cornell Scale for Depression Dementia use antidepressant medications. Magnetic resonance imaging computer tomography scans rated (MTA), using the Scheltens scale. For subsample...
Background: Cognitive deficits arising in the course of Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s (PDD) are directly linked to synaptic loss. Postmortem studies suggest that zinc transporter protein 3 (ZnT3), AMPA glutamate receptor (GluA3), Dynamin1 associated cognitive decline AD body patients. Objective: We aimed evaluate diagnostic value ZnT3, GluA3, Dynamin 1 cerebrospinal fluid (CSF) patients due AD, DLB, PDD compared cognitively normal subjective (SCD)...
Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or secondary outcome. For that reason, either diagnostic tools to monitor progression and/or pharmacological interventions, there need for robust biomarkers neuroinflammation in the brain. Mitochondrial TSPO (18 kDa Translocator protein) one few available which are clinically PET imaging agents. In this study, we further characterised mouse model prion-induced chronic neurodegeneration...
Background The association between mortality risk and use of antidepressants in people with dementia is unknown. Objective To describe the different diagnoses to explore associated 3 years before a diagnosis. Methods Study population included 20,050 memory clinic patients from Swedish Dementia Registry diagnosed incident dementia. Data on dispensed at time diagnosis during three-year period was obtained Prescribed Drug Register. Cox regression models were used. Results During median...
To explore the associations between depressive symptoms and cognition in patients with subjective cognitive impairment (SCI), mild (MCI) Alzheimer's disease (AD). 286 Patients (60.8% females) SCI (n=96), MCI (n=125), AD (n=65) from a University hospital-based memory clinic were compared several tests of performance. Mean (SD) age 67.73 (7.2) median (range) MMSE score 28 (16-30) Cornell Scale for Depression Dementia (CSDD) 5 (0-20). The three groups subdivided into those without depression as...