A5018680850- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- Ultrasound Imaging and Elastography
- Thermal Regulation in Medicine
- Cervical and Thoracic Myelopathy
- Photoacoustic and Ultrasonic Imaging
- Bone and Joint Diseases
- Advanced Differential Geometry Research
- Nicotinic Acetylcholine Receptors Study
- Medical Image Segmentation Techniques
St Thomas' Hospital
2020
King's College London
2020
Harvard University
2010-2014
Brigham and Women's Hospital
2010-2014
Zero to Three
2010
University College London
2007-2010
Abstract Objective To determine the relation of gray matter (GM) and white (WM) brain volumes, WM lesion load, with clinical outcomes 20 years after first presentation clinically isolated syndrome suggestive multiple sclerosis (MS). Methods Seventy‐three patients were studied a mean from (33 whom developed relapsing‐remitting MS 11 secondary‐progressive MS, rest experiencing no further definite neurological events), together 25 healthy control subjects. GM volumetric measures obtained...
To develop an automated lesion-filling technique (LEAP; LEsion Automated Preprocessing) that would reduce lesion-associated brain tissue segmentation bias (which is known to affect gray [GM] and white matter [WM] segmentations in people who have multiple sclerosis), a WM lesion simulation tool with which test it.Simulated lesions differing volumes signal intensities were added volumetric images from three healthy subjects then automatically filled values approximating normal WM. We tested...
Background: The aim of this study was to determine whether the diffusion tensor-derived radial diffusivity and axial diffusivity, measured in cortico-spinal tract cervical cord, predict clinical recovery after a cord relapse patients with multiple sclerosis, change over time. Methods: Fourteen were clinically assessed at onset 1, 3 6 months. Patients 13 age-matched healthy controls underwent spinal tensor imaging each time point. directional diffusivities from imaging, termed calculated...
<h3>BACKGROUND AND PURPOSE:</h3> VBM has been widely used to study GM atrophy in MS. MS lesions lead segmentation and registration errors that may affect the reliability of results. Improved have demonstrated by WM LI before segmentation. DARTEL appears improve versus USM. Our aim was compare performance VBM-DARTEL VBM-USM effect regional analysis <h3>MATERIALS METHODS:</h3> 3T T1 MR imaging scans were acquired from 26 patients with RRMS 28 age-matched NC. replaced normal-appearing...
Abstract There is increasing interest in imaging cadavers for noninvasive autopsies research purposes. However, the temperature well below that of vivo imaging, and a variety interesting ‘cold brain’ effects are observed. At lower temperatures conventional FLAIR sequences no longer produce dark cerebrospinal fluid (CSF); T 1 reduced from about 4.0 sec to 1.7 at 1°C. The diffusion coefficient (DC) CSF much (from 3.1 10 −9 m 2 s −1 1.1 1°C). DC values therefore provide thermometer measure...
Grey matter (GM) damage is a clinically relevant feature of multiple sclerosis (MS) that has been previously assessed with diffusion tensor imaging (DTI). Fractional anisotropy (FA) the basal ganglia and thalamus might be increased in MS patients, correlates disability scores. Despite established role striatum motor control, mood cognition, impact DTI changes within these structures on neuropsychological performance not yet specifically addressed MS. We investigated metrics deep GM nuclei...
ABSTRACT OBJECTIVE Atrophy of the corpus callosum is a recognized characteristic multiple sclerosis (MS). We describe new reliable method for measuring atrophy and correlate this with global cerebral measures. METHODS Whole brain 3T MRI was performed in 38 relapsing‐remitting MS subjects 21 healthy controls (HC). Brain gray white matter volumes were segmented SPM8. The contour outlined on midline 3‐D T1‐weighted images by semiautomated edge‐detection technique to determine area (CCA)....
Magnetic resonance imaging (MRI) of the brain and spinal cord has become a routine tool for diagnosis monitoring multiple sclerosis (MS) emerged as key supportive outcome measure in clinical trials. Conventional MRI lesion atrophy measures are particularly useful assessing macroscopic damage but lack sensitivity specificity to underlying MS pathology. They also show relatively weak relationships status such predictive strength change. Advanced MR techniques, diffusion, magnetization transfer...
Background: Multi-tracer PET/SPECT imaging enables different modality tracers to be present simultaneously, allowing multiple physiological processes imaged in the same subject, within a short time-frame. Fluorine-18 and technetium-99m, two commonly used PET SPECT radionuclides respectively, possess emission profiles, offering potential for one presence of other. However, impact each radionuclide on scanning other could significant lead confounding results. Here we use combinations 18F 99mTc...