A5039320437- Mosquito-borne diseases and control
- scientometrics and bibliometrics research
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Signaling Pathways in Disease
- Complex Network Analysis Techniques
- Maternal and Neonatal Healthcare
- Global Public Health Policies and Epidemiology
- Biotechnology and Related Fields
- Malaria Research and Control
- Business and Management Studies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Global Health and Surgery
- Innovation and Knowledge Management
- Recycling and Waste Management Techniques
- Extraction and Separation Processes
- Fungal Infections and Studies
- Parasites and Host Interactions
- Health, Nursing, Elderly Care
- HIV/AIDS Research and Interventions
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Plant Pathogens and Fungal Diseases
- HIV/AIDS Impact and Responses
Fundação Oswaldo Cruz
2014-2024
Universidade Federal do Rio de Janeiro
2015-2016
Instituto Nacional do Câncer
2005-2014
Instituto Biológico
2013
Although gay, bisexual, and other cisgender men who have sex with (MSM) transgender women the highest HIV burden in Latin America, pre-exposure prophylaxis (PrEP) implementation is poor. We aimed to assess feasibility of same-day oral PrEP delivery Brazil, Mexico, Peru.Implementation (ImPrEP) was a prospective, single-arm, open-label, multicentre study conducted Brazil (14 sites), Mexico (four Peru (ten sites). MSM were eligible participate if they aged 18 years or older, HIV-negative,...
Geographic accessibility to healthcare services is a fundamental component in achieving universal health coverage, the central commitment of Brazilian Unified Health System (SUS). For cancer patients, poor has been associated with inadequate treatment, worse prognosis, and poorer quality life.
Haematological and cytokine alterations in malaria are a broad controversial subject the literature. However, few studies have simultaneously evaluated various cytokines single patient group during acute convalescent phases of infection. The aim this study was to sequentially characterise haematological patters circulating plasma chemokine levels patients infected with Plasmodium vivax or falciparum from Brazilian endemic area During phase, thrombocytopaenia, eosinopaenia, lymphopaenia an...
Difficult access to birth care services is associated with infant and neonatal mortality maternal morbidity mortality. In this study, data from the Brazilian Unified National Health System (SUS) were used map evolution of geographic accessibility hospital usual risk in state Rio de Janeiro, Brazil, corresponding 418,243 admissions 2010-2011 2018-2019. Travel flows, distances traveled, intermunicipal travel time between pregnant women's municipality location estimated. An increase 15.9% 21.5%...
Abstract CD8+ T lymphocytes are excellent sources of IFN-γ; however, the molecular mechanisms that dictate IFN-γ expression upon TCR stimulation in these cells not completely understood. In this study, we evaluated involvement NFAT1 regulation gene murine and its relevance during Th differentiation. We show CD8+, but CD4+, cells, represent very first source primary cell activation, also produced by naive may enhance CD4+ Th1 differentiation vitro. rapidly induced a cyclosporin A-sensitive...
To assess the correlation between burden of seven priority neglected tropical diseases (NTDs) included in Brazilian National Agenda Priorities Health Research - tuberculosis, Chagas disease, leprosy, malaria, leishmaniasis, dengue and schistosomiasis their respective research funding output.This retrospective review obtained data on disease from Global Burden Disease Study open access sources. Publications were retrieved Scopus SciELO, characterised according to type conducted. Correlation...
Introduction Countries have traditionally been split into two major groups: developed or industrialized ("the North") and developing underdeveloped South"). Several authors organizations challenged this classification to recognize countries that reached an intermediate stage of social economic development. As proposed by Morel collaborators in 2005, the concept Innovative Developing (IDCs) defines a group nations with impactful scientific programs. Here, IDCs are reexamined variety metrics...
The recent Zika virus (ZIKAV) epidemics disclosed a major public health threat and scientific technological (S&T) challenge. lessons learned from the S&T response of Latin America Caribbean (LAC) countries are critical to inform further research guide investments. present study aimed assess how new knowledge produced disseminated regionally can contribute address global challenges. Scientometric social network analysis methods were used LAC contribution potential development on ZIKAV up...
Macrophage migration inhibitory factor (MIF) is increased in asthmatic patients and plays a critical role the pathogenesis of asthma. We show here that mice lacking MIF failed to develop airway hyper-responsiveness (AHR), tissue eosinophilia, mucus metaplasia. Analysis bronchoalveolar fluids revealed substantial reduction IL-13, eotaxin cysteinyl-leukotrienes. The lack these cardinal features asthma MIF(-/-) occurs regardless high concentrations IL-4 lung OVA-specific IgE serum....
Inhalation of the local anaesthetic lidocaine has been suggested to be beneficial for asthmatics, but airway anaesthesia is unpleasant and may exacerbate bronchoconstriction. Our previous study showed that inhalation analogue JMF2-1 can elicit anti-inflammatory properties without anaesthesia. This prompted further research on mechanism action putative therapeutic application JMF2-1.We tested hypothesis would prevent allergen-induced lung inflammation hyperresponsiveness (AHR) by modulating T...
BACKGROUND Despite the current global trend of reduction in morbidity and mortality neglected diseases, dengue's incidence has increased occurrence areas have expanded. Dengue also persists as a scientific technological challenge since there is no effective treatment, vaccine, vector control or public health intervention. Combining bibliometrics social network analysis methods can support mapping dengue research development (R&D) activities worldwide. OBJECTIVES The aim this paper to map...
Collaborative networks are of great value for science and technology (S&T) institutions as a way sharing, generating disseminating new knowledge that could ultimately lead to innovations. Driven by the need assess contribution effectiveness these in informing S&T management, we explored evolution dynamics tuberculosis scientific involving Oswaldo Cruz Foundation (Fiocruz), major public health Institution Brazil. Social network analysis (SNA) was used produce 10-year (2005–2009, 2010–2014)...
Engaging in collaborative networks can be an important facilitator of innovation for public sector science and technology (S&T) organizations. It is also component S&T policies that require indicators assess the through which these organizations innovate. In this study, we apply network to two are part Brazilian health sector. The cover complementary perspectives: one considers organizations' scientific other their technological networks. allowed analysis were engaged understanding aspects...
The COVID-19 pandemic triggered unprecedented scientific efforts worldwide and launched several initiatives to promote international cooperation. Because collaborations between high-income countries (HICs) low- middle-income (LMICs) are not always balanced, analyzing research leadership helps understand the global dynamics of knowledge production during COVID-19. In this study, we focused on HIC-LMIC in 469,937 publications first 2 years (2020-2021). Co-authorship authors' affiliation were...
ABSTRACT Hepatitis C virus (HCV) infection is a major burden to public health worldwide, affecting approximately 3% of the human population. Although HCV detection currently based on reliable tests, field medical diagnostics has growing need for inexpensive, accurate, and quick high-throughput assays. By using recombinant antigens NS3, NS4, NS5, Combined, we describe new bead-based multiplex test capable detecting in serum samples. The first analysis, made singleplex format, showed that each...
Allergic asthma is a chronic inflammatory disease of the lung whose incidence and morbidity continues to rise in developed nations. Despite being hallmark asthma, molecular mechanisms that determine airway hyperresponsiveness (AHR) are not completely established. Transcription factors NFAT family involved regulation several asthma-related genes. It has been shown absence NFAT1 leads an increased pleural eosinophilic allergic response accompanied by production Th2 cytokines, suggesting role...
In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore interaction between other parasites. Therefore, present study evaluates changes cytokine, chemokine, C-reactive protein, nitric oxide (NO) concentrations 264 individuals, comparing plasma from infected individuals concurrent to either infection alone uninfected. studied population 24% were Plasmodium 18% coinfected Protozoan comprised bulk...
The analysis of scientific networks has been applied in health research to map and measure relationships between researchers institutions, describing collaboration structures, individual roles, outputs, helping the identification knowledge gaps cooperation opportunities. Driven by dengue continued expansion Brazil, we explore contribution, dynamics consolidation that could ultimately inform prioritisation research, financial investments policy.Social network (SNA) was used produce a 20-year...
South-south collaboration on health and development research is a critical mechanism for social economic progress. It allows sharing replicating experiences to find "southern solution" meet shared challenges, such as access adequate HIV/AIDS prevention treatment. This study aimed generate evidence the dynamics of south-south in research, which could ultimately inform stakeholders progress nature towards increased capacities low- middle-income countries (LMIC). Bibliometric network analysis...
A new multiplex assay platform was evaluated to detect Trypanosoma cruzi infection using the recombinant antigens CRA, FRA, CRAFRA fusion and parasite lysate. The presented different sensitivity specificity in a singleplex test when compared serial dilution of two pools comprising 10 positive serum samples one pool negative samples. protein CRA lower (55%) contrast 100% T. These also showed good results duplex with CRAFRA/T. lysate better performance sensitivity, as well cut-off value...
O presente trabalho apresenta um metodologia para o estudo da comunicação científica derivado dos métodos de análise redes. São analisadas as relações profissionais colaboração entre autores que utilizam a coautoria, uma nova subárea vem ganhando espaço na ciência informação. Na dois quaisquer são definidos como tendo relacionamento caso tenham colaborado produção artigo ou publicação científica. investiga se tal associação permite entender problemáticas científica, por exemplo, conhecimento...