A5078668350- Diabetes and associated disorders
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Congenital Diaphragmatic Hernia Studies
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Diabetes Management and Research
- Neuroblastoma Research and Treatments
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- melanin and skin pigmentation
- Coenzyme Q10 studies and effects
- RNA Research and Splicing
- Nuclear Receptors and Signaling
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Olfactory and Sensory Function Studies
- Congenital heart defects research
- Neurological diseases and metabolism
- Retinal Development and Disorders
- Pancreatic function and diabetes
University of Pennsylvania
2022-2024
California Institute for Regenerative Medicine
2022-2024
California University of Pennsylvania
2024
University of California, Davis
2019-2021
Neuroscience Research Australia
2014
UNSW Sydney
2014
Disruption of pulmonary vascular homeostasis is a central feature viral pneumonia, wherein endothelial cell (EC) death and subsequent angiogenic responses are critical determinants the outcome severe lung injury. A more granular understanding fundamental mechanisms driving reconstitution endothelium necessary to facilitate therapeutic repair. Here, we demonstrated that TGF-β signaling through TGF-βR2 (transforming growth factor–β receptor 2) activated in ECs upon influenza infection, mice...
Abstract Inflammation induced by lung infection is a double-edged sword, moderating both anti-viral and immune pathogenesis effects; the mechanism of latter not fully understood. Previous studies suggest vasculature involved in tissue injury. Here, we report that expression Sparcl1, secreted matricellular protein, upregulated pulmonary capillary endothelial cells (EC) during influenza-induced Endothelial overexpression SPARCL1 promotes detrimental inflammation, with inducing ‘M1-like’...
Abstract In the neural progenitors of developing central nervous system (CNS), cell proliferation is tightly controlled and coordinated with fate decisions. Progenitors divide rapidly during early development their cycle lengthens progressively as advances to eventually give rise a tissue correct size cellular composition. However, our understanding molecules linking progression developmental time incomplete. Here, we show that microRNA (miRNA) let-7 accumulates in over throughout CNS....
Macrophages are key modulators of all inflammatory diseases and essential for their resolution, making macrophage cell therapy a promising strategy regenerative medicine. However, since macrophages change rapidly in response to microenvironmental cues, phenotype must be controlled post-administration. We present tunable biomaterial-based control intracellularly via small molecule-releasing microparticles. Poly(lactic-co-glycolic acid) microparticles encapsulating the anti-inflammatory...
Abstract Inflammation upon infectious lung injury is a double-edged sword: while tissue-infiltrating immune cells and cytokines are necessary to control infection, these same factors often aggravate injury. Full appreciation of both the sources targets inflammatory mediators required facilitate strategies maintain antimicrobial effects minimizing off-target epithelial endothelial damage. Recognizing that vasculature centrally involved in tissue responses we observed pulmonary capillary (ECs)...
Rod and cone photoreceptors differ in their shape, photopigment expression, synaptic connection patterns, light sensitivity, distribution across the retina. Although rods greatly outnumber cones, human vision is mostly dependent on since cones are essential for our sharp visual acuity color discrimination. In humans other primates, fovea centralis (fovea), a specialized region of central retina, contains highest density cones. Despite vast importance vision, molecular mechanisms guiding...
Abstract Unlike many mammalian vital organs, the lung exhibits a robust, multifaceted regenerative response to severe injuries such as influenza infection, which primarily targets epithelial cells in airways and alveoli. Quiescent lung-resident progenitors proliferate, migrate, differentiate following injury, participating two distinct reparative pathways: functionally beneficial regeneration dysplastic tissue remodeling. Intrapulmonary airway-resident basal-like p63 + are one progenitor...
ABSTRACT COVID-19 commonly presents as pneumonia, with those most severely affected progressing to respiratory failure. Patient responses SARS-CoV-2 infection are varied, comorbidities acting major contributors varied outcomes. Focusing on one such comorbidity, we assessed whether pharmacological induction of Type I Diabetes Mellitus (T1DM) would increase the severity lung injury in a murine model pneumonia utilizing wild type mice infected mouse-adapted SARS-CoV-2. Hyperglycemic exhibited...
COVID-19 commonly presents as pneumonia, with those most severely affected progressing to respiratory failure. Patient responses SARS-CoV-2 infection are varied, comorbidities acting contributors varied outcomes. Focusing on one such major comorbidity, we assessed whether pharmacological induction of Type I Diabetes Mellitus (T1DM) would increase the severity lung injury in a murine model pneumonia utilizing wild type mice infected mouse-adapted SARS-CoV-2. Hyperglycemic exhibited increased...