A5039651247- Medicinal Plant Research
- Sarcoma Diagnosis and Treatment
- Food and Agricultural Sciences
- Immunotherapy and Immune Responses
- Pregnancy and preeclampsia studies
- Fungal Biology and Applications
- Tannin, Tannase and Anticancer Activities
- MicroRNA in disease regulation
- Diverse Scientific Research Studies
- Cancer Immunotherapy and Biomarkers
- Agricultural and Biological Research
- Bone Tumor Diagnosis and Treatments
- Moringa oleifera research and applications
- Phytochemistry and Bioactivity Studies
- Public Health and Nutrition
- Blockchain Technology in Education and Learning
- Cancer, Lipids, and Metabolism
- Natural Antidiabetic Agents Studies
- Data Mining and Machine Learning Applications
- Phytochemical compounds biological activities
- Computer Science and Engineering
- Medicinal Plants and Neuroprotection
- Birth, Development, and Health
- Phytoestrogen effects and research
- Cancer-related molecular mechanisms research
University of Brawijaya
2015-2024
RSUD Prof. Dr. Saiful Anwar Malang
2018-2024
Rumah Sakit Umum Pusat Dr. Sardjito
2015
Indonesian mistletoe grows on various trees. Mango Mistletoes (Dendrophthoe pentandra) is one type of that grown mango tree (.benalu mangga in bahasa Indonesia). Our study used as a parasitic plant has been for traditional medicine. It known Dendrophtoe pentandra extract (DPE) anti-inflammatory and anticancer. Furthermore, it necessary to follow-up vivo evaluate the response treatment new cancer therapeutic agents. This research aimed determine levels IL-22, myeloperoxide (MPO),...
Introduction: Diagnosing soft tissue tumors is challenging due to the complexity of sarcomas, which are malignancies with heterogeneous histological and molecular subtypes, often resulting in delayed diagnoses. The gold standard for examining histopathological examination, which, while definitive, costly invasive. Fine Needle Aspiration Biopsy (FNAB) an alternative method that can be used as initial screening tool provide differential diagnoses tumors. FNAB considered affordable minimally...
Context: Matrix metalloproteinase-2 (MMP-2) is a protein found in tumor cells and important breast cancer spread development. Natural substances like quercetin, cardenolide, epicatechin, coumarin, anthraquinone have been studied for their ability to block MMP-2 activity, which may lead lower invasiveness reduced spread. These bioactive compounds present potential treatment options targeting slowing down the progress of cancer. Aims: To determine mechanism inhibition by active Sterculia...
Context: Breast cancer is characterized by the abnormal growth of cells in ducts and lobules breast. Numerous therapeutic targets for breast are currently under investigation, one which matrix metalloproteinase-2 (MMP-2), a heterodimeric protein highly expressed circulating tumor from patients with pancreatic carcinoma, positioning it as potential target therapy. Anredera cordifolia plant known its medicinal properties anti-cancer effects, particularly cancer. Aims: To determine compounds...
During Plasmodium berghei (P. berghei) infection, infected erythrocytes are sequestered in gut tissues through microvascular circulation, leading to dysbiosis. This study aimed investigate the effect of Lactobacillus casei (L. casei) and Bifidobacterium longum (B. longum) administration on parasitemia level, microbiota composition, expression cluster differentiation 103 (CD103) intestinal dendritic T regulatory cells (T reg), plasma interferon gamma (IFN-γ) tumor necrosis factor (TNF-α)...
Stroke is a medical condition characterized by sudden, localized neurological impairment caused damage to the central nervous system due either blockage or bleeding in blood vessels. This process leads increased oxidation, which can exacerbate brain damage. Flavonoids are compounds that widely found nature and considered have numerous health benefits. 7,8‑dihydroxyflavone (7,8‑DHF) flavonoid has tropomyosin receptor kinase B agonist activity. However, other beneficial activities of 7,8‑DHF...
This paper presents a novel algorithm for computer-assisted classification of cervical cancers using digitized histology images biopsies. Texture analysis the nuclei structure is very important cancer histology. In this we present two-tier strategy Gabor filter banks local and abnormality spread global taxonomy. The test data used in work are biopsies acquired from pathology laboratories Saiful An war Hospital Indonesia. over 500 subjects categorized by pathologists into five grades, benign,...
Introduction. Immunotherapy has been widely used in the treatment of various malignancies with satisfactory results. One agents for immunotherapy is an inhibitor programmed cell death-1 and its ligands (PD-1 PD-L1). However, attempts at utilizing PD-1/PD-L1 osteosarcoma have not yielded favorable This may be due to differences PD-L1 regulation immune landscape osteosarcoma, as mechanism still poorly understood. Therefore, elucidating paramount order improve results using immunotherapy....
Meta-analysis of GWAS in East Asian populations had established 10 loci that were associated with type 2 diabetes. Eight them genome-wide significance and two a border line association. Since these data have not been studied an independent Han Chinese population, we aimed to investigate the association susceptibility diabetes population. We executed case-control study 000 by SNPscan method. Firstly, repetitive sequences assessed. Next, investigated 8 SNPs out constructed GRS those SNPs....
Context: Triple-negative breast cancer (TNBC) has poor prognosis, high mortality, and recurrence rates. Ixabepilone or ixempra could be a promising agent for TNBC, especially in the taxane- and/or anthracycline-resistant population. Aims: To evaluate efficacy safety of ixabepilone-based chemotherapy compared to ixabepilone-free TNBC patients. Methods: This review followed preferred reporting items systematic reviews meta-analysis guidelines. The eligibility criteria included randomized...
Context: Colorectal cancer (CRC) is a major global health concern as innovative therapeutic strategies to enhance treatment outcomes. This study investigates the potential of ethanol extract derived from Volvariella volvacea in combination with cetuximab for CRC. Aims: To evaluate inhibition topoisomerase II alpha (TOP2A) and include peroxisome proliferator-activated receptor gamma (PPARγ), key regulator cell growth differentiation. Methods: The method used computational modeling molecular...
To investigate the anti-inflammatory effect of protein derived from soluble factor Heligmosomoides polygyrus (H. polygyrus) excretory-secretory in a colitis model. Colitis was induced by providing drinking water containing 3% dextran sodium sulfate (DSS) for week. DSS administrated cycle protocol, each consisted 7 days and followed regular water. This study five treatment groups, including Groups A (control) received untreated water, B (DSS only, without excretory-secretory), C–E injected...
Ulcerative colitis is a major risk factor that increases the occurrence of colorectal cancer. In cancer due to colitis, intestinal inflammation plays an important role which causes DNA damage. The aim this study investigate anticancer effect coelomic fluid Eisenia fetida (CFEF) and cetuximab combinations. Colitis associated colon was induced in BALB/c mice by DSS/AOM. were randomly divided into six groups: group 1 received vehicle (control), groups 2-6 DSS/AOM, 3-5 + CFEF (30, 60, or 120...
Cytotoxic effects and anti-proliferative cancer activity of coelomic fluid from Lumbricus rubellus promotes apoptosis reduces G2/M phase progression in HT-29 cellsSofy Permana, Pearlindah, Zurniatus Sholihah, Agustin Iskandar, Hani Susanti, Agustina Tri Endharti
Setelah menopause, wanita kehilangan efek protektif dari estrogen, sehingga merubah jalannya remodeling tulang dan akhirnya  terjadi osteoporosis. T ujuan penelitian ini untuk mengetahui apakah ekstrak kacang tunggak dengan kandungan genistein didalamnya dapat berperan sebagai fitoestrogen yang menjadi alternatif terapi pengganti estrogen pada tikus telah diovarektomi. Pada digunakan 6 kelompok yaitu: 1) normal (K-neg), 2) di ovarektomi dan dipertahankan selama 1 bulan (K-pos1), 3) 2...
Introduction: Osteosarcoma is the most common primary non-hematopoietic malignant bone tumor, which reportedly has a high incidence in several regions of world including South-east Asia. However Indonesia, data regarding osteosarcoma trends and clinicopathological features are still lacking. Therefore, this paper aims to describe cases tertiary referral hospital Indonesia. Methods: A retrospective study at Department Anatomic Pathology East Java was conducted. Clinicopathological diagnosed...
Granular cell tumors (GCTs) are uncommon soft tissue characterized by the cytoplasmic granular appearance of neoplastic cells. Malignant GCTs rare neural tumors, intensely aggressive. Both occurrence malignant and its similarities in features with their benign lesions make diagnosis this malignancy difficult. comprise less than 2% mostly found subcutaneous tissues lower extremities, especially thighs. This article presents a case large left thigh 46-year-old woman. Plain radiograph...
Lymphomas are malignant lymphocyte neoplasms that globally account for 10% of cancers in individuals aged <20 years. Malignant lymphomas divided into Hodgkin's lymphoma (HL) and non-Hodgkin's (NHL). Despite the availability many therapeutic modalities lymphoma, such as
Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by uncontrolled proliferation of progenitor cells in the bone marrow. The standard chemotherapy treating AML cases anthracycline, including doxorubicin; however, it could cause severe side effects if administered continuously at high doses, making less tolerable for some patients. Evodia suaveolens, herbal medicine, known to contain active compounds and anti-cancer activities, which inhibit cancer cell proliferation....
Basal Cell Carcinoma (BCC) is the most common cancer in many countries, with its incidence steadily rising. Data from Indonesian Pathologists Association show that among 1,530 skin cases, BCC was frequent (39.93%), followed by Squamous (23%) and Malignant Melanoma (7.9%). According to 2018 WHO classification, divided into Low-Risk High-Risk groups based on risk of recurrence. invades surrounding tissues through extracellular matrix degradation enhanced cell motility, driven expression MMP-9...