A5001772573- Pain Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Botulinum Toxin and Related Neurological Disorders
- Migraine and Headache Studies
- Peripheral Nerve Disorders
- Musculoskeletal pain and rehabilitation
- Nerve injury and regeneration
- Sleep and Wakefulness Research
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Pain Management and Treatment
- Leprosy Research and Treatment
- Nerve Injury and Rehabilitation
- Ophthalmology and Eye Disorders
- Spine and Intervertebral Disc Pathology
- Cancer Treatment and Pharmacology
- Myasthenia Gravis and Thymoma
- Neurological Disorders and Treatments
- Zebrafish Biomedical Research Applications
- Herpesvirus Infections and Treatments
- Epilepsy research and treatment
- Laser Applications in Dentistry and Medicine
University of Brawijaya
2015-2024
Beicip Franlab (France)
2024
University of Surabaya
2022
Hospital Italiano de Buenos Aires
2015
Carpal Tunnel Syndrome (CTS) is a neuropathy disease that affects the median nerve with an incidence of around 90%. appears in 3.8% general population, highest prevalence occurring women. There are several risk factors associated CTS, namely medical and non-medical factors. The mechanism carpal tunnel syndrome until now still very complex not known certainty, but compression traction thought to be most common cause CTS. can manifest clinically subjective signs such as paresthesia,...
Background: Medical professionals are often found using cervical provocation tests and Electromyography (EMG) examination to diagnose Cervical Root Syndrome (CRS). Although EMG examinations unavailable in primary health care facilities due the lack of equipment, results expected correlate with findings examination. Objective: This study aimed investigate correlation between (Lhermitte Spurling) compression severity CRS. Methods: 85 medical records that met inclusion exclusion criteria were...
During Plasmodium berghei (P. berghei) infection, infected erythrocytes are sequestered in gut tissues through microvascular circulation, leading to dysbiosis. This study aimed investigate the effect of Lactobacillus casei (L. casei) and Bifidobacterium longum (B. longum) administration on parasitemia level, microbiota composition, expression cluster differentiation 103 (CD103) intestinal dendritic T regulatory cells (T reg), plasma interferon gamma (IFN-γ) tumor necrosis factor (TNF-α)...
Background: Resistance and side effects of antiepileptic drugs (AEDs) pose a challenge in epilepsy therapy due to the limited drug bioavailability penetrating Blood-Brain Barrier (BBB). Nanoparticles can be one solution by encapsulating AEDs enhance distribution target cells. This study systematically assesses 1) characteristics nanoparticles, 2) potential nanoparticle managing seizures experimental animal models. Methods: systematic literature review is studies published between 2013 July...
Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition that lasts 3 months or more after an outbreak of shingles. Herpes zoster, especially acute herpes associated with the reactivation inactivated varicella zoster virus in individuals who have had chickenpox. PHN persistent and often refractory pain. Patients may experience several types pain, including deep intolerable burning, paroxysmal stabbing hyperalgesia, allodynia. Pharmacological treatment include variety drugs,...
Insomnia is difficulty initiating or maintaining sleep for at least three nights a week more and lasting 3 months. One of the molecules that play role in circadian rhythm arousal system
Low back pain is the most common symptom found in primary health care and number one cause of disability throughout worldwide. It estimated that around 60 – 80% world population will experience during their lifespan. There are three different source spine: axial-lumbosacral, radicular reffered pain. All these brings clinical presentations. could be classified as acute, subacute chronic low The nociceptive or neuropathic, symptoms reported “pressure pain” “pain attack”. physician should aware...
Pain is a sensory experience that responded to as an unpleasant stimulus often caused by tissue damage. Perdossi defines pain and emotional due damage, both actual potential, or which described in the form of such can affect everyone regardless sex, age, race, social status, occupation. Myofascial syndrome (MPS) term used describe condition acute chronic musculoskeletal soft tissue. This indicated findings sensory, motoric, autonomic symptoms related myofascial trigger points (MTRP). The be...
Tension Type Headache (TTH) is the most common type of headache in all age groups worldwide. Because its high prevalence and possible association with medical psychiatric comorbidities, TTH has a large socioeconomic impact. that patients suffer from, ranging from mild to severe pain reduces their ability carry out daily activities. can be classified into an episodic tension-type (ETTH) chronic (CTTH). The lifetime (78%). Approximately 24% 37% experience several times month, 10% weekly 2% 3%...
Parkinson's disease is a neurodegenerative disorder that progressive about the movement or control of movement. The often occurs in people over age 60 years. etiology caused by combination genetic and environmental factors. Because overall life expectancy increases, number with will increase future. Treatment can be used pharmacological therapy nonpharmacological therapy. Pharmacological use levodopa, monoamine oxidase-B inhibitors, dopamine agonists, anticholinergics amantadine, while...
Diabetic Neuropathy is the most common complication from diabetes, which experienced in almost 90% diabetes patient. Evenly pain one of symptoms diabetic neuropathic, but pathophysiology mechanism not clearly known. The hyptosesis toxicity hyperglycemia on development has been widely accepted globally, there other proposed hypothesis. Basic concept management painful neuropathic exclusion cause peripheral neuropathy, improving glycemic control for prophylaxis therapy and medication use...
Ca2+ signaling functions to regulate many cellular processes. Dynamics of or homeostasis is regulated by the interaction between ON and OFF reactions that control flux in both plasma membrane internal organelles such as endoplasmic reticulum (ER) mitochondria. External stimuli activate reactions, which include into cytoplasm either through channels from storage like ER. Most cells utilize channels/sources, but there area few using an external source certain Ca entering adsorbed buffer, while...
Epilepsy therapy is almost always chronic and often used more than one drug. Currently, antiepileptic drugs are still the mainstay of for epilepsy. An understanding pharmacodynamics pharmacokinetics these would be very helpful in choosing right medication develop a study to determine drug's mechanism further. Mechanism action AED (anti epileptic drug) can categorized into four main groups: (1) modulation voltage-gated ion channels, including sodium, calcium, potassium; (2) increase GABA...
Background: Insomnia is defined as difficulty falling or staying asleep a sleep state that cannot restore the body's condition. The zebrafish (Danio rerio) vertebrate model has been extensively studied to study and neurological disorders. One of most widely used methods examine effect light-dark cycle on circadian system by exposing animals humans pulse wave light. Objective: To see light exposure larvae looking at inactive duration latency in insomnia model. Methods: This four groups i.e :...
Background. Carpal tunnel syndrome (CTS) is caused by entrapment neuropathy of the median nerve in carpal that can be detected with electroneuromyography (ENMG).Objective. To determine whether there are significant differences parameters ENMG examination between CTS groups mild-to-moderate and severe clinical symptoms.Methods. The study design was observational analytic using cross sectional approach patient's medical record data as many 61 samples.Results. From samples, were dominancy age...
Background. One of the regenerative therapy modalities in Parkinson is using beta glucan effect contained Saccharomyces cerevisae.Objective. To identify reduction alpha synuclein expression on brain substantia nigra Parkinson's rat model after given cerevisae. Methods. This research applied true experimental design by vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each them consisted 5 rats. Variables measured were decreasing level...
Glioblastoma is the most common primary malignant tumor in neural tissue and a highly aggressive human. It involves glial cells 52% of functional brain cases 20% all intracranial tumors. Extra cranial metastasis very rare. Metastasis outside CNS was uncommon GBM but it could occur with frequency 0.2% can spread head neck sites. The mechanism this not understood yet. extracranial routes were speculated on direct lymphatic connections, venous system adjacent structure like dura bone. We...
In oncopharmacology, the common procedure to evaluate median-effect concentrations (IC50) on experimental data is based use of well-established kinetic models representing inhibition effects drugs human cancer cell lines.Several widespread software programs, such as GraphPad Prism and CompuSyn offer possibilities for calculation IC50 through model Chou.In recent study, we analyzed results from those two programs compared them with non-linear programming written by us in MAPLE symbolic...
Background: Coronavirus disease 2019 (Covid-19) caused by SARS-Cov-2 had been spreading worldwide including Indonesia, but In it was difficult to diagnose confirmation Covid-19 Polymerase Change Reaction (PCR). and in clinical practice treat covid-19, Indonesia Health Ministry use term probable covid-19 for patients under observation Covid-19, study neurological manifestation on is very lacking.Objective: Knowing the of patient Covid-19.Methods: Observational from medical record...
Insomnia is inability to maintain or elevate sleep quality at least three times a day, more than days in week, months. One of theories that explaining insomnia causes focuses on condition called hyperarousal, which related increasing mental, cognitive, and motor activities. This study was applied create the model, zebrafish larvae were exposed ilumination with intensity 200 lux. There four phases light exposure, consist 12 hours dark, 18 6 flash. The flash phase group divided into two groups...
Numerous studies have investigated seizures in zebrafish, employing diverse methods to induce and observe epilepsy. Chemical inducers become indispensable tools for precisely manipulating neural activity controlled experiments. This research is dedicated a meticulous comparison analysis of various seizure-inducing chemicals zebrafish. The selected chemical include pentylenetetrazole (PTZ), kainic acid (KA), picrotoxin (PTX), pilocarpine, other substances. primary mechanism these involves...
<ns3:p><ns3:italic>Background:</ns3:italic> Insomnia is difficulty initiating or maintaining sleep for at least three nights a week more and lasting 3 months. One of the molecules that play role in circadian rhythm arousal system <ns3:italic>hypocretin/orexin.</ns3:italic> Orexin activates p38-MAPK signaling pathway increases phosphorylated ERK1/2 levels. <ns3:italic>Centella asiatica</ns3:italic> (CA) has signal work MAPK/ERK, Akt, p38 path many various diseases....