<ns5:p><ns5:italic>Background.</ns5:italic> Cigarette smoking could induce endothelial dysfunction and the increase of circulating markers inflammation by activation monocytes. This can lead to increased intima media thickness (IMT) entire blood vessels result in acceleration atherosclerosis process. However, our knowledge, little is known about role cigarette this atherosclerotic inflammatory The aim study explore link between its effect on nitric oxide synthase (e-NOS) vascular cell...

BackgroundPolice officers are known for fieldwork shifts, psychological stress, and prolonged physical activity that associated with cardiovascular disease (CVD). We aim to determine the differences in CVD risks factor Atherogenic Index of Plasma (AIP) profiles as a predictor cardiac events between police civilians developing country an evaluation strategic preventive measure CVD.Methods978 participants were enrolled subjects this cross-sectional study. Data used obtained during medical...

Background. One of the regenerative therapy modalities in Parkinson is using beta glucan effect contained Saccharomyces cerevisae.Objective. To identify reduction alpha synuclein expression on brain substantia nigra Parkinson's rat model after given cerevisae. Methods. This research applied true experimental design by vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each them consisted 5 rats. Variables measured were decreasing level...

Background Cigarette smoking could induce endothelial dysfunction and increase of circulating markers inflammation by activation monocytes. This can lead to the increased intima media thickness (IMT) entire blood vessel result acceleration atherosclerosis process. However, our knowledge, little is known about role cigarette in this atherosclerotic inflammatory Objective The aim study explore link between on nitric oxide synthase (e-NOS) vascular cell adhesion molecule 1 (VCAM-1). Methods An...

The compounds in cigarette smoke are believed to cause oxidative stress, leading endothelial dysfunction. Understanding the mechanism of dysfunction due is useful for development early and preventive therapy cardiovascular diseases (CVDs) with smoking risk factors.In this experimental study, a posttest-only control group design was used. 20 Wistar rats were divided into two groups: (exposed 40 cigarettes per day 4 weeks) group. After exposure, animals sacrificed aortas removed measurement...

Abstract Purpose The aim of this study was to determine the effect active immunization interleukin ( IL )‐17A inhibit B cell functions and monitor risk infection in a pristane‐induced lupus mice model. Methods Female Balb/c were given single intraperitoneal injection 0.5 mL pristane. ‐17A coupled keyhole limpet hemocyanin KLH ) three different doses: D0 (0 μg/mL), D1 (1 μg/ ), D2 (10 ). vaccine times with 3‐week intervals. At day 42, injected intraperitoneally methicillin‐resistant...

The expression of angiotensin-converting enzyme 2 (ACE2) in the adipose tissues obese patients needs further study, as it may aid infection and serve a viral reservoir. There has been controversy over whether to use ACE inhibitors prevent coronavirus disease 2019 (COVID-19) severity. Perindopril, an ACE2 inhibitor, proposed; however, its relationship with COVID-19 not yet clear. aim this study was investigate effect perindopril reduce pro-inflammatory cytokine adipocytes exposed severe acute...

Obesity has emerged as a worldwide health concern due to its increasing prevalence. Adipocytes have the ability express angiotensin-converting enzyme 2 receptors (ACE2) and several adipocytokines. These expressions could lead activation of cytokine storm, which in turn promotes development cardiovascular diseases. The aim this study was investigate impact perindopril losartan exposure on ACE2 interleukin 6 (IL-6) levels adipocyte cells. This used an vivo true experimental design utilizing...

BACKGROUND Angiotensin-converting enzyme 2 (ACE2) has a role in SARS-CoV-2 incidence, and digoxin is competitive inhibitor of SARS-CoV-2-ACE2 binding. This study aimed to investigate the effects on binding, proinflammatory cytokines, prothrombotic factors adipocytes patients with COVID-19. METHODS vitro used adipocyte cultures, which were divided into negative control, positive control (SARS-CoV-2 S1 spike protein only), digoxin, human recombinant soluble ACE2 (hrsACE2). Data analyzed using...

Highlights: Around 38.8% of heart failure patients with cachexia died during the 180-1,876-day follow-up period. Cachexia increases risk mortality in patients. Abstract: Despite fact that obesity has long been recognized as a factor for cardiovascular disease, rate (HF) is still high. Several studies have conducted to investigate association between and HF However, research results vary, do diagnostic criteria employed assess cachexia. This meta-analysis aimed conclusively summarize The data...

BACKGROUND: High angiotensin-converting enzyme 2 (ACE2) expression in adipocyte cells facilitates the initiation of SARS-CoV-2 infection and triggers a cytokine storm. This finding suggests that obesity is an independent risk factor for severity symptoms caused by COVID-19. The use cardiovascular medications focus on ACE2, such as angiotensin II receptor blockers, remains controversial, their effects inflammatory production ACE2 cells, especially adipocytes, remain inconsistent.METHODS:...

<ns3:p><ns3:bold>Background</ns3:bold>. Cigarette smoking could induce endothelial dysfunction and the increase of circulating markers inflammation by activation monocytes. This can lead to increased intima media thickness (IMT) entire blood vessels result in acceleration atherosclerosis process. However, our knowledge, little is known about role cigarette this atherosclerotic inflammatory process.</ns3:p><ns3:p> The aim study explore link between its effect on nitric oxide synthase (e-NOS)...

The development of a direct reprogramming method to provide cell availability for regenerative therapy has led lot studies. However, the search appropriate sources and methods is still being carried out until now. Direct using microRNA-1 (miR-1) an option obtain cardiomyocytes from other cells because miR-1 evidence play role in cardiac muscle embryo. This study aimed compare efficiency CD34+ peripheral blood into between cardiomyocyte differentiation medium miR-1. isolation expansion...

BACKGROUND: Transdifferentiation is a method to provide cells sources for cellular cardiomyoplasty. CD34+ are potential because these can differentiate into cardiomyocytes through several mechanisms. MicroRNA (miR-1) known have the ability inhibit expression of histone deacetylase 4 (HDAC4). HDAC4 gene that essentially contributes in differentiation. However, study reporting an evidence miR-1 induce transdifferentiation peripheral blood mature limited.METHODS: were taken from and isolated...

<ns5:p><ns5:bold>Background</ns5:bold>. Cigarette smoking could induce endothelial dysfunction and the increase of circulating markers inflammation by activation monocytes. This can lead to increased intima media thickness (IMT) entire blood vessels result in acceleration atherosclerosis process. However, our knowledge, little is known about role cigarette this atherosclerotic inflammatory process.</ns5:p><ns5:p> The aim study explore link between its effect on nitric oxide synthase (e-NOS)...

Introduction: Around 50% of patients with heart failure (HF) have an existing iron deficiency (ID), or without anemia. With such a high prevalence, more research is underway to determine whether addressing ID can improve HF. Aims: This study aimed critically evaluate the beneficial effects intravenous administration for chronic Methods: Studies were searched in Medline, Embase, and Cochrane trials investigating effect supplementation on HF patients. Outcomes all-cause hospitalizations, as...

Acute hyperglycemia or stress commonly occurs in critically ill patients and could be a marker of disease severity. Hyperglycemia at hospital admission is found with cardiovascular disease, regardless their diabetic status; one them arrhythmia. Arrhythmia dysrhythmia heart rhythm disorder that refers to any disturbance the frequency, regularity, location origin electrical impulses conduction heart. Arrhythmias associated include atrial arrhythmias, supraventricular tachycardia (SVT),...

Coronary collateral artery (CCA) is an alternative source of blood supply to ischemic myocardial region. It generally believed that there a beneficial effect collaterals in patients with coronary disease (CAD). Recently, reliable methods have become available for the assessment adequacy flow. However, debate regarding importance CCA different clinical settings continues. In this review article, we discuss about functional relevance provide overview its impact on prognosis CAD.